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    SMAD2 SMAD family member 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 480144, updated on 5-Mar-2024

    Summary

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    Official Symbol
    SMAD2provided by VGNC
    Official Full Name
    SMAD family member 2provided by VGNC
    Primary source
    VGNC:VGNC:46519
    See related
    Ensembl:ENSCAFG00845002338
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 7
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (43649238..43731066)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (43181631..43262778)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (43688637..43769813)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (43350952..43432066)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (43405083..43486241)

    Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119872686 Neighboring gene uncharacterized LOC119872687 Neighboring gene uncharacterized LOC111096745 Neighboring gene uncharacterized LOC102156787 Neighboring gene uncharacterized LOC111096896

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Immunolocalisation and expression of Smad2 and Smad4 proteins in dog testis during postnatal development. Zhang XJ, et al. Andrologia, 2011 Aug. PMID 21486406
    2. IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation. Lin CS, et al. Cytokine, 2013 Jun. PMID 23579028

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IL-6 markedly decreased the nuclear concentration of a TGF-beta signaling transducer, Smad 2/3.
      Title: IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation.
    2. The temporospatial distribution of Smad2 and Smad4 proteins in testicular cells suggests that these two signalling molecules may play an important role in specific stages of testicular development and spermatogenesis.
      Title: Immunolocalisation and expression of Smad2 and Smad4 proteins in dog testis during postnatal development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables I-SMAD binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in SMAD protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of heteromeric SMAD protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mothers against decapentaplegic homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051811.1 Reference ROS_Cfam_1.0

      Range
      43649238..43731066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038672133.1 → XP_038528061.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
      Related
      ENSCAFP00845003314.1, ENSCAFT00845004143.1
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. XM_038672135.1 → XP_038528063.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0RNY3
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:260 → 440
      MH2; C-terminal Mad Homology 2 (MH2) domain

    3. XM_038672136.1 → XP_038528064.1  mothers against decapentaplegic homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0PZC9, A0A8C0PZE1, A0A8I3MF91, A0A8I3MMS3
      Related
      ENSCAFP00845003325.1, ENSCAFT00845004155.1
      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236 → 426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    4. XM_038672132.1 → XP_038528060.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    5. XM_038672134.1 → XP_038528062.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049267.1 Alternate UMICH_Zoey_3.1

      Range
      43350952..43432066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038481945.1 → XP_038337873.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. XM_038481947.1 → XP_038337875.1  mothers against decapentaplegic homolog 2 isoform X2

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:260 → 440
      MH2; C-terminal Mad Homology 2 (MH2) domain

    3. XM_038481948.1 → XP_038337876.1  mothers against decapentaplegic homolog 2 isoform X3

      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236 → 426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    4. XM_038481944.1 → XP_038337872.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    5. XM_038481946.1 → XP_038337874.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

      Range
      43405083..43486241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038607438.1 → XP_038463366.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. XM_038607440.1 → XP_038463368.1  mothers against decapentaplegic homolog 2 isoform X2

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:260 → 440
      MH2; C-terminal Mad Homology 2 (MH2) domain

    3. XM_038607441.1 → XP_038463369.1  mothers against decapentaplegic homolog 2 isoform X3

      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236 → 426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    4. XM_038607437.1 → XP_038463365.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    5. XM_038607439.1 → XP_038463367.1  mothers against decapentaplegic homolog 2 isoform X1

      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

      Range
      43688637..43769813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038543327.1 → XP_038399255.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. XM_038543329.1 → XP_038399257.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0RNY3
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:260 → 440
      MH2; C-terminal Mad Homology 2 (MH2) domain

    3. XM_038543330.1 → XP_038399258.1  mothers against decapentaplegic homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0PZC9, A0A8C0PZE1, A0A8I3MF91, A0A8I3MMS3
      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236 → 426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    4. XM_038543326.1 → XP_038399254.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    5. XM_038543328.1 → XP_038399256.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      43181631..43262778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_847706.6 → XP_852799.1  mothers against decapentaplegic homolog 2 isoform X1

      See identical proteins and their annotated locations for XP_852799.1

      UniProtKB/TrEMBL
      A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    2. XM_038572971.1 → XP_038428899.1  mothers against decapentaplegic homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0RNY3
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cl00056
      Location:260 → 440
      MH2; C-terminal Mad Homology 2 (MH2) domain

    3. XM_038572973.1 → XP_038428901.1  mothers against decapentaplegic homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0PZC9, A0A8C0PZE1, A0A8I3MF91, A0A8I3MMS3
      Conserved Domains (2) summary
      cd10491
      Location:8 → 142
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:236 → 426
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    4. XM_038572947.1 → XP_038428875.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3

    5. XM_038572963.1 → XP_038428891.1  mothers against decapentaplegic homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0RNY3, A0A8C0RP35, A0A8I3MFT9
      Conserved Domains (2) summary
      cd10491
      Location:8 → 172
      MH1_SMAD_2_3; N-terminal Mad Homology 1 (MH1) domain in SMAD2 and SMAD3
      cd10985
      Location:266 → 456
      MH2_SMAD_2_3; C-terminal Mad Homology 2 (MH2) domain in SMAD2 and SMAD3
    Nucleotide Protein
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