Hcrt hypocretin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hcrtprovided by MGI
Official Full Name: hypocretinprovided by MGI
Primary source: MGI:MGI:1202306
See related: Ensembl:ENSMUSG00000045471 AllianceGenome:MGI:1202306
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PPOX
Summary: This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors Hcrtr1 and Hcrtr2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Sep 2015]
Expression: Biased expression in testis adult (RPKM 1.4), CNS E18 (RPKM 0.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.6 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100652519..100653757, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100761693..100762931, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice.
Title: Diurnal Characteristics of the Orexin System Genes and Its Effects on Pathology at Early Stage in 3xTg-AD Mice.
Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology Differently in Male and Female Mice.
Title: Mild Traumatic Brain Injury Affects Orexin/Hypocretin Physiology Differently in Male and Female Mice.
The role of orexin neuron activity in sleep/wakefulness regulation.
Title: The role of orexin neuron activity in sleep/wakefulness regulation.
Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development.
Title: Localization and expression of Orexin B (OXB) and its type 2 receptor (OX2R) in mouse testis during postnatal development.
Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.
Title: Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity.
Anterior cingulate cortex orexin signaling mediates early-life stress-induced social impairment in females.
Title: Anterior cingulate cortex orexin signaling mediates early-life stress-induced social impairment in females.
Engagement of the brain orexin system in activity-based anorexia behaviour in mice.
Title: Engagement of the brain orexin system in activity-based anorexia behaviour in mice.
The development of sleep/wake disruption and cataplexy as hypocretin/orexin neurons degenerate in male vs. female Orexin/tTA; TetO-DTA Mice.
Title: The development of sleep/wake disruption and cataplexy as hypocretin/orexin neurons degenerate in male vs. female Orexin/tTA; TetO-DTA Mice.
Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.
Title: Mutual Effects of Orexin and Bone Morphogenetic Proteins on Gonadotropin Expression by Mouse Gonadotrope Cells.
Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems.
Title: Sleep-wake and arousal dysfunctions in post-traumatic stress disorder: Role of orexin systems.

Submit: New GeneRIF Correction See all GeneRIFs (114)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Markers

PMC18213P1 (e-PCR)
- UniSTS:271676

AW456382 (e-PCR)
- UniSTS:208747

NoName (e-PCR)
- UniSTS:492247

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables type 1 orexin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 orexin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 2 orexin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 2 orexin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in eating behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transmission of nerve impulse	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transmission of nerve impulse	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sleep	IBA Inferred from Biological aspect of Ancestor more info
involved_in temperature homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hypocretin neuropeptide precursor

Names: hypocretin neuropeptide; orexin A; orexin B; prepro-orexin; preprohypocretin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.