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    alpi.1 alkaline phosphatase, intestinal, tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 541539, updated on 14-Apr-2024

    Summary

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    Official Symbol
    alpi.1provided by ZNC
    Official Full Name
    alkaline phosphatase, intestinal, tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050327-78
    See related
    Ensembl:ENSDARG00000015273 AllianceGenome:ZFIN:ZDB-GENE-050327-78
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    alpi; im:7149588; wu:fa95f04; zgc:110794; si:ch211-262h13.1
    Summary
    Predicted to enable alkaline phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in plasma membrane. Predicted to be anchored component of membrane. Is expressed in several structures, including floor plate; intestine; median fin fold; periderm; and segmental plate. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (38762807..38778038)
    105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (38776068..38791293)

    Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene si:ch211-126j24.1 Neighboring gene natriuretic peptide C Neighboring gene si:ch211-262h13.3 Neighboring gene alkaline phosphatase, intestinal, tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Dynamic Evolution of the LPS-Detoxifying Enzyme Intestinal Alkaline Phosphatase in Zebrafish and Other Vertebrates. Yang Y, et al. Front Immunol, 2012. PMID 23091474, Free PMC Article
    2. Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Bates JM, et al. Cell Host Microbe, 2007 Dec 13. PMID 18078689, Free PMC Article
    3. Dynamic Lkb1-TORC1 signaling as a possible mechanism for regulating the endoderm-intestine transition. Marshall KE, et al. Dev Dyn, 2010 Nov. PMID 20925120, Free PMC Article
    4. Soybean Meal and Soy Protein Concentrate in Early Diet Elicit Different Nutritional Programming Effects on Juvenile Zebrafish. Perera E, et al. Zebrafish, 2016 Feb. PMID 26716770
    5. High-Fat Diet Consumption Induces Microbiota Dysbiosis and Intestinal Inflammation in Zebrafish. Arias-Jayo N, et al. Microb Ecol, 2018 Nov. PMID 29736898

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alkaline phosphatase, intestinal, tandem duplicate 1; intestinal-type alkaline phosphatase
    Names
    alkaline phosphatase, intestinal.1
    iap
    intestinal alkaline phosphatase 1
    NP_001014375.1
    XP_009294806.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014353.1 → NP_001014375.1  alkaline phosphatase, intestinal, tandem duplicate 1 precursor

      See identical proteins and their annotated locations for NP_001014375.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091940
      UniProtKB/TrEMBL
      Q58EF1
      Related
      ENSDARP00000016216.10, ENSDART00000015016.10
      Conserved Domains (2) summary
      COG1785
      Location:46 → 493
      PhoA; Alkaline phosphatase [Inorganic ion transport and metabolism, General function prediction only]
      pfam00245
      Location:61 → 496
      Alk_phosphatase; Alkaline phosphatase

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007133.7 Reference GRCz11 Primary Assembly

      Range
      38762807..38778038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009296531.2 → XP_009294806.1  intestinal-type alkaline phosphatase isoform X1

      UniProtKB/TrEMBL
      A0A8M3B5T5
      Conserved Domains (1) summary
      pfam00245
      Location:28 → 417
      Alk_phosphatase; Alkaline phosphatase
    Nucleotide Protein Strain
    Heading Accession and Version

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