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    SEC26 coatomer subunit beta [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851824, updated on 13-Apr-2024

    Summary

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    Gene symbol
    SEC26
    Gene description
    coatomer subunit beta
    Primary source
    SGD:S000002646
    Locus tag
    YDR238C
    See related
    AllianceGenome:SGD:S000002646
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable structural molecule activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intracellular mRNA localization. Part of COPI vesicle coat. Orthologous to human COPB1 (COPI coat complex subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (937895..940816, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene riboflavin kinase Neighboring gene mitochondrial 54S ribosomal protein YmL7/YmL5 Neighboring gene uncharacterized protein Neighboring gene Snu56p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis of betaCOP (Sec26p) identifies an appendage domain critical for function. DeRegis CJ, et al. BMC Cell Biol, 2008 Jan 22. PMID 18211691, Free PMC Article
    2. Conserved structural motifs in intracellular trafficking pathways: structure of the gammaCOP appendage domain. Hoffman GR, et al. Mol Cell, 2003 Sep. PMID 14527408
    3. An Essential Role for COPI in mRNA Localization to Mitochondria and Mitochondrial Function. Zabezhinsky D, et al. Cell Rep, 2016 Apr 19. PMID 27068463
    4. Effects of mutations in the WD40 domain of α-COP on its interaction with the COPI coatomer in Saccharomyces cerevisiae. Kim KH, et al. J Microbiol, 2012 Apr. PMID 22538654
    5. Cex1 is a component of the COPI intracellular trafficking machinery. Enkler L, et al. Biol Open, 2021 Mar 22. PMID 33753324, Free PMC Article

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COPI vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in COPI-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit beta
    NP_010524.3
    • Essential beta-coat protein of the COPI coatomer; involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      937895..940816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180546.3 → NP_010524.3  TPA: coatomer subunit beta [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010524.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSL9, P41810, Q03779
      UniProtKB/TrEMBL
      A0A8H8UNE3, A6ZYJ1, C8Z5E9, G2WAY2, N1P518
      Conserved Domains (1) summary
      COG5096
      Location:1 → 941
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41810.2

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