imb-1 Importin N-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: imb-1
Gene description: Importin N-terminal domain-containing protein
Primary source: WormBase:WBGene00002075
Locus tag: CELE_F28B3.8
See related: AllianceGenome:WB:WBGene00002075
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in embryo development and reproduction. Predicted to be active in cytoplasm and nucleus. Orthologous to human KPNB1 (karyopherin subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See imb-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 14

Sequence:: Chromosome: I; NC_003279.8 (4920759..4926233, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

both IMA-2 and IMB-1, the homologues of vertebrate importin alpha and beta, are essential for both spindle assembly and nuclear formation in early embryos
Title: Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F28B3.5 (e-PCR)
- UniSTS:309999

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Importin N-terminal domain-containing protein

NP_491477.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4920759..4926233 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059076.8 → NP_491477.2 Importin N-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491477.2

Status: REVIEWED

UniProtKB/TrEMBL

Q9BIB8

Conserved Domains (2) summary

COG5215
Location:17 → 883

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:331 → 361

HEAT; HEAT repeat [structural motif]