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    Ilk Integrin linked kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53573, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Ilkprovided by FlyBase
    Official Full Name
    Integrin linked kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028427
    Locus tag
    Dmel_CG10504
    See related
    AllianceGenome:FB:FBgn0028427
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10504; CT29478; Dmel\CG10504; DmILK; ilk; ILK; l(3)78Ca
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in apposition of dorsal and ventral imaginal disc-derived wing surfaces; cell-matrix adhesion; and muscle attachment. Located in focal adhesion. Is expressed in several structures, including adult CNS glial cell; circulatory system; extended germ band embryo; germ layer; and muscle system. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human ILK (integrin linked kinase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    78C2-78C2; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21216901..21219240)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21210001..21212340)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene tRNA methyltransferase subunit 11-2 Neighboring gene uncharacterized protein Neighboring gene Ecdysone-induced protein 78C Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A dual role for integrin-linked kinase and β1-integrin in modulating cardiac aging. Nishimura M, et al. Aging Cell, 2014 Jun. PMID 24400780, Free PMC Article
    2. Integrin-linked kinase modulates longevity and thermotolerance in C. elegans through neuronal control of HSF-1. Kumsta C, et al. Aging Cell, 2014 Jun. PMID 24314125, Free PMC Article
    3. The integrin-actin connection, an eternal love affair. Brakebusch C, et al. EMBO J, 2003 May 15. PMID 12743027, Free PMC Article
    4. Integrin-linked kinase (ILK) and its interactors: a new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes. Wu C, et al. J Cell Biol, 2001 Nov 12. PMID 11696562, Free PMC Article
    5. Epithelial morphogenesis in the Drosophila egg chamber requires Parvin and ILK. Keramidioti A, et al. Front Cell Dev Biol, 2022. PMID 36531940, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH, and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.
      Title: Integrin Adhesions Suppress Syncytium Formation in the Drosophila Larval Epidermis.
    2. PINCH and ILK have an independent capacity to localize at muscle attachment sites in vivo.
      Title: A crucial role for Ras suppressor-1 (RSU-1) revealed when PINCH and ILK binding is disrupted.
    3. ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.
      Title: A central multifunctional role of integrin-linked kinase at muscle attachment sites.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables protein kinase activity IKR
    Inferred from Key Residues
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apposition of dorsal and ventral imaginal disc-derived wing surfaces IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    colocalizes_with stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    integrin linked kinase
    Names
    CG10504-PA
    CG10504-PB
    Ilk-PA
    Ilk-PB
    Integrin-linked kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      21216901..21219240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080262.4 → NP_525001.2  integrin linked kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525001.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NHC7, Q9V400
      Related
      FBpp0077962
      Conserved Domains (5) summary
      smart00221
      Location:204 → 443
      STYKc; Protein kinase; unclassified specificity
      cd00204
      Location:28 → 140
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14057
      Location:196 → 446
      PK_ILK; Pseudokinase domain of Integrin Linked Kinase
      pfam12796
      Location:38 → 130
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:33 → 64
      ANK; ANK repeat [structural motif]

    2. NM_001259931.1 → NP_001246860.1  integrin linked kinase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTS5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E3CTS5 E3CTS5
    Q9NHC7 Q9NHC7
    Q9V400 Q9V400

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