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    SEA4 Sea4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852170, updated on 13-Apr-2024

    Summary

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    Gene symbol
    SEA4
    Gene description
    Sea4p
    Primary source
    SGD:S000000200
    Locus tag
    YBL104C
    See related
    AllianceGenome:SGD:S000000200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YBL103C-A
    Summary
    Involved in positive regulation of TORC1 signaling. Is extrinsic component of fungal-type vacuolar membrane. Part of Seh1-associated complex. Orthologous to human MIOS (meiosis regulator for oocyte development). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SEA4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (18177..21293, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene putative Rab GTPase-binding protein SRO77 Neighboring gene protein kinase C Neighboring gene Rtg3p Neighboring gene Sft2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Computer analysis of the entire budding yeast genome for putative targets of the GCN4 transcription factor. Schuldiner O, et al. Curr Genet, 1998 Jan. PMID 9472075
    2. Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae. Polleys EJ, et al. G3 (Bethesda), 2015 May 4. PMID 25943524, Free PMC Article
    3. Bayesian Markov Random Field analysis for protein function prediction based on network data. Kourmpetis YA, et al. PLoS One, 2010 Feb 24. PMID 20195360, Free PMC Article
    4. Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Panchaud N, et al. Sci Signal, 2013 May 28. PMID 23716719
    5. Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis. Ajazi A, et al. Dev Cell, 2021 Sep 27. PMID 34534458

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Seh1-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sea4p
    NP_009446.2
    • Subunit of SEACAT, a subcomplex of the SEA complex; Sea4p, along with Rtc1p and Mtc5p, redundantly inhibit the TORC1 inhibitory role of the Iml1p/SEACIT (Iml1p-Npr2p-Npr3p) subcomplex, a GAP for GTPase Gtr1p (EGOC subunit) in response to amino acid limitation, thereby resulting in activation of TORC1 signaling; SEA is a coatomer-related complex that associates dynamically with the vacuole; contains an N-terminal beta-propeller fold and a C-terminal RING motif

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      18177..21293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178344.1 → NP_009446.2  TPA: Sea4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009446.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPP9, P38164, Q86ZS4
      UniProtKB/TrEMBL
      A0A8H4F7L2, A6ZKK0, B3LNN4, G2W8R0
      Conserved Domains (1) summary
      cl24077
      Location:943 → 1036
      Zn_ribbon_17; Zinc-ribbon, C4HC2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38164.2

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