LOI1 Pentatricopeptide repeat (PPR) superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: LOI1
Gene description: Pentatricopeptide repeat (PPR) superfamily protein
Primary source: Araport:AT4G14850
Locus tag: AT4G14850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: DL3465W; FCAALL.335; lovastatin insensitive 1; MEF11; mitochondrial RNA editing factor 11
Summary: Encodes a pentatricopeptide (PPR) protein that binds single-stranded RNA. The N-terminal portion of the protein can localize to the mitochondria. Mutations in this gene make plants less sensitive to inhibitors of the MEP and MVA pathways of isoprenoid biosynthesis and increase the activity of HMG CoA reductase.
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Genomic context

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Location:: chromosome: 4

Exon count:: 2

Sequence:: Chromosome: 4; NC_003075.7 (8513807..8516360)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A restorer-of-fertility-like pentatricopeptide repeat protein promotes cytoplasmic male sterility in Arabidopsis thaliana.
Title: A restorer-of-fertility-like pentatricopeptide repeat protein promotes cytoplasmic male sterility in Arabidopsis thaliana.
he upstream sequences of the BLX-targeted editing sites are not conserved, suggesting that BLX serves as a novel and major mitochondrial editing factor (MEF) via a new non-RNA-interacting manner. This finding provides new insights into how a DYW-type PPR protein with fewer PPR motifs regulates RNA editing in plants.
Title: Novel DYW-type pentatricopeptide repeat (PPR) protein BLX controls mitochondrial RNA editing and splicing essential for early seed development of Arabidopsis.
These observations suggest that the enzymatic activity or its recruitment is not compromised by the alteration of the C-terminus of MEF11.
Title: A truncated MEF11 protein shows site-specific effects on mitochondrial RNA editing.
MEF11 is a nuclear encoded gene which is involved in RNA editing of the three sites cox3-422, nad4-124 and ccb203-344 in Arabidopsis thaliana mitochondria. [MEF11]
Title: The PPR protein encoded by the LOVASTATIN INSENSITIVE 1 gene is involved in RNA editing at three sites in mitochondria of Arabidopsis thaliana.
Identification of RNA editing factor MEF11 as the loi1 gene product
Title: The PPR protein encoded by the LOVASTATIN INSENSITIVE 1 gene is involved in RNA editing at three sites in mitochondria of Arabidopsis thaliana.
report that LOI1 is an essential factor for RNA editing of three mitochondrial genes, nad4, ccb203 and cox3.
Title: The mitochondrial PPR protein LOVASTATIN INSENSITIVE 1 plays regulatory roles in cytosolic and plastidial isoprenoid biosynthesis through RNA editing.

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General gene information

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Homology

Orthologs from OrthoDB

NM_117571.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables poly(G) binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA modification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process, mevalonate pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Pentatricopeptide repeat (PPR) superfamily protein

NP_193221.3

lovastatin insensitive 1 (LOI1); CONTAINS InterPro DOMAIN/s: Pentatricopeptide repeat (InterPro:IPR002885); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT5G09950.1); Has 35457 Blast hits to 13266 proteins in 222 species: Archae - 0; Bacteria - 4; Metazoa - 55; Fungi - 21; Plants - 34914; Viruses - 0; Other Eukaryotes - 463 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

8513807..8516360

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117571.5 → NP_193221.3 Pentatricopeptide repeat (PPR) superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193221.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O23340, Q0WSH6, Q6NQI9

UniProtKB/TrEMBL

A0A178V1D8

Conserved Domains (5) summary

PLN03081
Location:53 → 684

PLN03081; pentatricopeptide (PPR) repeat-containing protein; Provisional

TIGR00756
Location:74 → 108

PPR; pentatricopeptide repeat domain (PPR motif)

sd00004
Location:378 → 405

PPR; PPR repeat [structural motif]

pfam01535
Location:377 → 402

PPR; PPR repeat

pfam14432
Location:551 → 674

DYW_deaminase; DYW family of nucleic acid deaminases