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    IDO1 indoleamine 2,3-dioxygenase 1 [ Canis lupus familiaris (dog) ]

    Gene ID: 475574, updated on 5-Mar-2024

    Summary

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    Official Symbol
    IDO1provided by VGNC
    Official Full Name
    indoleamine 2,3-dioxygenase 1provided by VGNC
    Primary source
    VGNC:VGNC:41865
    See related
    Ensembl:ENSCAFG00845009259
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    INDO
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 16 NC_051820.1 (27218925..27234204, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 16 NC_006598.4 (25901596..25916857, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 16 NC_049237.1 (26131508..26146796, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 16 NC_049276.1 (25516922..25532182, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 16 NC_049757.1 (26072694..26087946, complement)

    Chromosome 16 - NC_051820.1Genomic Context describing neighboring genes Neighboring gene transcriptional and immune response regulator Neighboring gene uncharacterized LOC111090284 Neighboring gene uncharacterized LOC102153319 Neighboring gene indoleamine 2,3-dioxygenase 2 Neighboring gene splicing factor 3B subunit 4-like Neighboring gene A disintegrin and metallopeptidase domain 3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy. Kathrani A, et al. PLoS One, 2019. PMID 31181125, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. decreased serum tryptophan concentrations in dogs with protein-losing enteropathy is associated with increased intestinal IDO-1 expression.
      Title: Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables indoleamine 2,3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tryptophan 2,3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    indoleamine 2,3-dioxygenase 1
    Names
    indoleamine-pyrrole 2,3 dioxygenase
    XP_038353469.1
    XP_038415932.1
    XP_038479963.1
    XP_038545722.1
    XP_532793.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051820.1 Reference ROS_Cfam_1.0

      Range
      27218925..27234204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038689794.1 → XP_038545722.1  indoleamine 2,3-dioxygenase 1

      UniProtKB/TrEMBL
      A0A8C0JP29, A0A8C0MXE9, A0A8I3N1Y1, A0A8I3N7I0, A0A8P0TEA8
      Related
      ENSCAFP00845012750.1, ENSCAFT00845016390.1
      Conserved Domains (1) summary
      pfam01231
      Location:16 → 401
      IDO; Indoleamine 2,3-dioxygenase

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049276.1 Alternate UMICH_Zoey_3.1

      Range
      25516922..25532182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038497541.1 → XP_038353469.1  indoleamine 2,3-dioxygenase 1

      Conserved Domains (1) summary
      pfam01231
      Location:16 → 401
      IDO; Indoleamine 2,3-dioxygenase

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049757.1 Alternate UNSW_CanFamBas_1.0

      Range
      26072694..26087946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038624035.1 → XP_038479963.1  indoleamine 2,3-dioxygenase 1

      Conserved Domains (1) summary
      pfam01231
      Location:16 → 401
      IDO; Indoleamine 2,3-dioxygenase

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049237.1 Alternate UU_Cfam_GSD_1.0

      Range
      26131508..26146796 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038560004.1 → XP_038415932.1  indoleamine 2,3-dioxygenase 1

      UniProtKB/TrEMBL
      A0A8C0JP29, A0A8C0MXE9, A0A8I3N1Y1, A0A8I3N7I0, A0A8P0TEA8
      Conserved Domains (1) summary
      pfam01231
      Location:16 → 401
      IDO; Indoleamine 2,3-dioxygenase

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006598.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      25901596..25916857 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_532793.7 → XP_532793.1  indoleamine 2,3-dioxygenase 1

      UniProtKB/TrEMBL
      A0A8C0JP29, A0A8C0MXE9, A0A8I3N1Y1, A0A8I3N7I0, A0A8P0TEA8
      Conserved Domains (1) summary
      pfam01231
      Location:16 → 401
      IDO; Indoleamine 2,3-dioxygenase
    Nucleotide Protein
    Heading Accession and Version

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