Suv39h2 SUV39H2 histone lysine methyltransferase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Suv39h2provided by RGD
Official Full Name: SUV39H2 histone lysine methyltransferaseprovided by RGD
Primary source: RGD:1306969
See related: Ensembl:ENSRNOG00000015585 AllianceGenome:RGD:1306969
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; cation binding activity; and histone methyltransferase activity (H3-K9 specific). Predicted to be involved in several processes, including chromatin organization; histone H3-K9 methylation; and negative regulation of circadian rhythm. Predicted to act upstream of or within several processes, including cellular response to hypoxia; histone H3-K9 methylation; and male meiotic nuclear division. Predicted to be located in heterochromatin. Predicted to be active in nucleus. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 55.2), Testes (RPKM 30.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (79665467..79684492)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (74756290..74775332)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (78762897..78782016)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

ksks283 (e-PCR)
- UniSTS:514323

RH133530 (e-PCR)
- UniSTS:216813

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone H3 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K9 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K9 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K9 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K9me2 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in epigenetic programming in the zygotic pronuclei	ISO Inferred from Sequence Orthology more info
involved_in male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
part_of heterochromatin	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase SUV39H2

Names: suppressor of variegation 3-9 homolog 2

NP_001102353.1

EC 2.1.1.354

XP_038951911.1

EC 2.1.1.354

XP_063132746.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108883.1 → NP_001102353.1 histone-lysine N-methyltransferase SUV39H2

See identical proteins and their annotated locations for NP_001102353.1

Status: PROVISIONAL

Source sequence(s)

CH473990

UniProtKB/TrEMBL

A6JM14, D3ZIH5

Related

ENSRNOP00000020924.3, ENSRNOT00000020924.5

Conserved Domains (4) summary

smart00317
Location:321 → 450

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:236 → 481

SET; SET domain-containing protein (function unknown) [General function prediction only]

pfam00385
Location:119 → 164

Chromo; Chromo (CHRromatin Organization MOdifier) domain

pfam05033
Location:225 → 313

Pre-SET; Pre-SET motif

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

79665467..79684492

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095983.2 → XP_038951911.1 histone-lysine N-methyltransferase SUV39H2 isoform X1

Conserved Domains (2) summary

cd18639
Location:148 → 196

CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins

cd10532
Location:268 → 510

SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
XM_063276676.1 → XP_063132746.1 histone-lysine N-methyltransferase SUV39H2 isoform X2