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    Ca-alpha1D Ca[2+]-channel protein alpha[[1]] subunit D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34950, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Ca-alpha1Dprovided by FlyBase
    Official Full Name
    Ca[2+]-channel protein alpha[[1]] subunit Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001991
    Locus tag
    Dmel_CG4894
    See related
    AllianceGenome:FB:FBgn0001991
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    A1D; alpha1; alpha1D; BG:DS02795.1; Ca-a1D; Ca-alpha1; ca-alpha1d; ca-alpha1D; Ca-Alpha1D; Ca-alphaID; Ca-alpha[[1]]D; Ca-_1D; Ca1D; Caalpha1D; cad; CAD; caID; Ca_alpha1D; CG4894; D-type Ca[2+]; DmCa1alpha1; dmca1D; Dmca1D; DmCa1D; Dmel\CG4894; DroCa1; l(2)35Fa; l35Fa
    Summary
    Enables voltage-gated calcium channel activity. Involved in several processes, including calcium ion transmembrane transport; epithelial fluid transport; and neuron remodeling. Located in apical plasma membrane and basolateral plasma membrane. Part of voltage-gated calcium channel complex. Is expressed in adult head; organism; presumptive embryonic/larval nervous system; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Brugada syndrome 3; Timothy syndrome; eye disease (multiple); hypokalemic periodic paralysis; and malignant hyperthermia. Orthologous to several human genes including CACNA1C (calcium voltage-gated channel subunit alpha1 C) and CACNA1S (calcium voltage-gated channel subunit alpha1 S). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    35E5-35E6; 2-51 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16165831..16190540)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16165831..16190540)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44871 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43806 Neighboring gene long non-coding RNA:CR44734 Neighboring gene long non-coding RNA:CR44735

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Focal laser stimulation of fly nociceptors activates distinct axonal and dendritic Ca(2+) signals. Basak R, et al. Biophys J, 2021 Aug 3. PMID 34175294, Free PMC Article
    2. Restoration of Olfactory Memory in Drosophila Overexpressing Human Alzheimer's Disease Associated Tau by Manipulation of L-Type Ca(2+) Channels. Higham JP, et al. Front Cell Neurosci, 2019. PMID 31551716, Free PMC Article
    3. Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion. Kadas D, et al. J Neurosci, 2017 Nov 8. PMID 28986465, Free PMC Article
    4. The Dmca1D channel mediates Ca(2+) inward currents in Drosophila embryonic muscles. Hara Y, et al. J Neurogenet, 2015. PMID 26004544
    5. Evidence of more ion channels inhibited by celecoxib: KV1.3 and L-type Ca(2+) channels. Frolov RV, et al. BMC Res Notes, 2015 Mar 1. PMID 25889233, Free PMC Article

    See all (131) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Separation of presynaptic Cav2 and Cav1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
      Title: Separation of presynaptic Ca(v)2 and Ca(v)1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca(2+) pump PMCA.
    2. Stac protein regulates release of neuropeptides.
      Title: Stac protein regulates release of neuropeptides.
    3. Co-immunoprecipitation analysis supports association between Ma2/d and Amph, and indirectly with Msp300. Ma2/d, in association with Msp300 and Amph, mediates interactions between the SR and the nuclear membrane.
      Title: Ma2/d promotes myonuclear positioning and association with the sarcoplasmic reticulum.
    4. maximum intraburst firing rates require axonal calcium influx through Dmca1D channels, likely to enhance sodium channel de-inactivation via a fast afterhyperpolarization through BK channel activation
      Title: Dendritic and Axonal L-Type Calcium Channels Cooperate to Enhance Motoneuron Firing Output during Drosophila Larval Locomotion.
    5. The Ca(2+) current in the embryonic muscle was completely eliminated in Dmca1D mutants, indicating that the Dmca1D-encoded Ca(2+) channel is the major mediator of inward currents in the body wall muscles throughout the embryonic and larval stages.
      Title: The Dmca1D channel mediates Ca(2+) inward currents in Drosophila embryonic muscles.
    6. cac and Dmca1D Ca(2+) channels differentially contribute to functional and structural aspects of slo-induced synaptic modifications
      Title: Distinct roles of Drosophila cacophony and Dmca1D Ca(2+) channels in synaptic homeostasis: genetic interactions with slowpoke Ca(2+) -activated BK channels in presynaptic excitability and postsynaptic response.
    7. The study indicated that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions.
      Title: Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions.
    8. This is the first characterization of an alpha2delta-3 mutant in any organism and indicates a necessary role for alpha2delta-3 in presynaptic vesicle release and calcium channel expression at active zones.
      Title: Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables high voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables voltage-gated calcium channel activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in calcium-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial fluid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in epithelial fluid transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated calcium channel complex IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    part_of voltage-gated calcium channel complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ca[2+]-channel protein alpha[[1]] subunit D
    Names
    CG4894-PF
    CG4894-PG
    CG4894-PH
    CG4894-PI
    CG4894-PJ
    CG4894-PK
    CG4894-PL
    CG4894-PM
    CG4894-PN
    CG4894-PO
    Ca-alpha1D-PF
    Ca-alpha1D-PG
    Ca-alpha1D-PH
    Ca-alpha1D-PI
    Ca-alpha1D-PJ
    Ca-alpha1D-PK
    Ca-alpha1D-PL
    Ca-alpha1D-PM
    Ca-alpha1D-PN
    Ca-alpha1D-PO
    Ca2+-channel protein alpha1 subunit D
    Ca[2+]-channel alpha1 subunit
    alpha-1 subunit Ca2[+] channel type D
    calcium channel alpha-1 subunit
    drosophila melanogaster calcium channel alpha[[1]] subunit DHP-sensitive

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      16165831..16190540
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273556.1 → NP_001260485.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PDI5
      Conserved Domains (4) summary
      pfam00520
      Location:1223 → 1480
      Ion_trans; Ion transport protein
      pfam08763
      Location:1553 → 1625
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1843 → 1924
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1488 → 1551
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    2. NM_001273555.1 → NP_001260484.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260484.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PD04
      Conserved Domains (4) summary
      pfam00520
      Location:1190 → 1447
      Ion_trans; Ion transport protein
      pfam08763
      Location:1520 → 1592
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1810 → 1891
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1455 → 1518
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    3. NM_001273552.1 → NP_001260481.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260481.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PD78
      Conserved Domains (4) summary
      pfam00520
      Location:1187 → 1444
      Ion_trans; Ion transport protein
      pfam08763
      Location:1517 → 1589
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1807 → 1888
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1452 → 1515
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    4. NM_001273553.1 → NP_001260482.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260482.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFZ4
      Conserved Domains (3) summary
      pfam00520
      Location:1187 → 1444
      Ion_trans; Ion transport protein
      pfam08763
      Location:1517 → 1589
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:1452 → 1515
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    5. NM_001273554.1 → NP_001260483.1  Ca[2+]-channel protein alpha[[1]] subunit D, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260483.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PBC0
      Conserved Domains (4) summary
      pfam00520
      Location:1187 → 1444
      Ion_trans; Ion transport protein
      pfam08763
      Location:1517 → 1589
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16885
      Location:1807 → 1888
      CAC1F_C; Voltage-gated calcium channel subunit alpha, C-term
      pfam16905
      Location:1452 → 1515
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    6. NM_134429.3 → NP_602305.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      Conserved Domains (3) summary
      pfam00520
      Location:767 → 1042
      Ion_trans; Ion transport protein
      pfam08763
      Location:2163 → 2235
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:2099 → 2152
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    7. NM_165147.2 → NP_723953.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      Conserved Domains (3) summary
      pfam00520
      Location:767 → 1042
      Ion_trans; Ion transport protein
      pfam08763
      Location:2163 → 2235
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:2099 → 2152
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    8. NM_080365.3 → NP_525104.3  Ca[2+]-channel protein alpha[[1]] subunit D, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      Conserved Domains (3) summary
      pfam00520
      Location:767 → 1042
      Ion_trans; Ion transport protein
      pfam08763
      Location:2166 → 2238
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:2102 → 2155
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    9. NM_001273551.1 → NP_001260480.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      UniProtKB/TrEMBL
      M9PDI1
      Conserved Domains (3) summary
      pfam00520
      Location:799 → 1074
      Ion_trans; Ion transport protein
      pfam08763
      Location:2192 → 2267
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:2129 → 2182
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated

    10. NM_165146.2 → NP_723952.2  Ca[2+]-channel protein alpha[[1]] subunit D, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24270, Q8IP23, Q8IP24, Q8IP25, Q95U73, Q9V3P7
      Conserved Domains (3) summary
      pfam00520
      Location:767 → 1042
      Ion_trans; Ion transport protein
      pfam08763
      Location:2199 → 2271
      Ca_chan_IQ; Voltage gated calcium channel IQ domain
      pfam16905
      Location:2135 → 2188
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBC0 M9PBC0
    M9PD04 M9PD04
    M9PD78 M9PD78
    M9PDI1 M9PDI1
    M9PDI5 M9PDI5
    M9PFZ4 M9PFZ4
    Q24270.2 Q24270

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