Klf11 KLF transcription factor 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Klf11provided by RGD
Official Full Name: KLF transcription factor 11provided by RGD
Primary source: RGD:1306646
See related: Ensembl:ENSRNOG00000054259 AllianceGenome:RGD:1306646
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tcfcp2l2
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to peptide. Predicted to be located in cytosol; focal adhesion; and nuclear body. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to human KLF11 (Kruppel like factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 80.6), Heart (RPKM 58.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (47014312..47026152)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (41285699..41297548)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (43829812..43841649)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In hypoxia/reoxygenation injury of rat cardiomyocytes, inhibition of KLF11 by siRNA suppressed apoptosis, the activity of caspase3, the expression of cleaved-caspase3 and cytochrome C in the cytoplasm and the damage of mitochondrial membrane. KLF11 knockdown elevated the expression of p-JAK2 and p-STAT3. KLF11 silencing protects against H/R injury by activating the JAK2/STAT3 signaling pathway .
Title: Knockdown of KLF11 attenuates hypoxia/reoxygenation injury via JAK2/STAT3 signaling in H9c2.
Kruppel-like factor 11 protein is up-regulated following chronic exposure to stress or ethanol in a region-specific manner and may contribute to pro-apoptotic signaling in ethanol-treated rats.
Title: Chronic Social Stress and Ethanol Increase Expression of KLF11, a Cell Death Mediator, in Rat Brain.
an important role for KLF11 in the regulation of INS transcription via the novel c.-331 KLF site.
Title: Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to peptide	IEP Inferred from Expression Pattern more info	PubMed
NOT acts_upstream_of_or_within hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Krueppel-like factor 11

Names: Kruppel-like factor 11; transcription factor CP2-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037354.2 → NP_001032431.2 Krueppel-like factor 11

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

E9PTS6, Q309C9

Related

ENSRNOP00000075389.1, ENSRNOT00000086548.2

Conserved Domains (4) summary

COG5048
Location:381 → 438

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:388 → 407

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:443 → 465

zf-C2H2; Zinc finger, C2H2 type

cd21584
Location:40 → 383

KLF11_N; N-terminal domain of Kruppel-like factor 11

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

47014312..47026152

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239984.5 → XP_006240046.1 Krueppel-like factor 11 isoform X1

UniProtKB/TrEMBL

Q309C9

Conserved Domains (2) summary

sd00017
Location:385 → 407

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:383 → 407

zf-C2H2; Zinc finger, C2H2 type