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    TEX29 testis expressed 29 [ Homo sapiens (human) ]

    Gene ID: 121793, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TEX29provided by HGNC
    Official Full Name
    testis expressed 29provided by HGNC
    Primary source
    HGNC:HGNC:20370
    See related
    Ensembl:ENSG00000153495 AllianceGenome:HGNC:20370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C13orf16; bA474D23.1
    Summary
    Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis (RPKM 4.7) and brain (RPKM 0.3) See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    13q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (111316185..111344248)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (110545648..110575278)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (111968532..111996595)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101060553 Neighboring gene ARHGEF7 antisense RNA 1 Neighboring gene Rho guanine nucleotide exchange factor 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8028 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:111850373-111850578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111858211-111858712 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111858713-111859212 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:111864035-111864562 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111866216-111866751 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr13:111867287-111867821 Neighboring gene spalt like transcription factor 4 pseudogene 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:111932258-111933457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:111948473-111948972 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:111967966-111968521 Neighboring gene uncharacterized LOC105370365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112041571-112042071 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_32439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112055149-112055694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112055695-112056240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112056241-112056784 Neighboring gene uncharacterized LOC107984618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112127213-112127713 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:112184322-112185016 Neighboring gene VISTA enhancer hs1246 Neighboring gene long intergenic non-protein coding RNA 2337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:112273941-112274466 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:112274467-112274991 Neighboring gene uncharacterized LOC107983958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112281066-112281884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112285479-112285978 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:112286679-112287245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:112288868-112289368

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Perry JR, et al. Nature, 2014 Oct 2. PMID 25231870, Free PMC Article
    2. The DNA sequence and analysis of human chromosome 13. Dunham A, et al. Nature, 2004 Apr 1. PMID 15057823, Free PMC Article
    3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061
    4. Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease. Teixeira FR, et al. Biochem J, 2016 Oct 15. PMID 27503909, Free PMC Article
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC35169

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    testis-expressed protein 29
    Names
    testis-expressed sequence 29 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303133.1 → NP_001290062.1  testis-expressed protein 29 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL160395, AW957098, BC029889, HY035354
      UniProtKB/Swiss-Prot
      Q8N6K0
      Conserved Domains (1) summary
      pfam15839
      Location:80 → 111
      TEX29; Testis-expressed sequence 29 protein

    2. NM_152324.3 → NP_689537.1  testis-expressed protein 29 isoform 2

      See identical proteins and their annotated locations for NP_689537.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate internal coding exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL160395, BC029889, HY035354
      Consensus CDS
      CCDS9522.1
      UniProtKB/Swiss-Prot
      Q8N6K0
      Related
      ENSP00000283547.1, ENST00000283547.2
      Conserved Domains (1) summary
      pfam15839
      Location:13 → 88
      TEX29; Testis-expressed sequence 29 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      111316185..111344248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020387.2 → XP_016875876.2  testis-expressed protein 29 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      110545648..110575278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374097.1 → XP_054230072.1  testis-expressed protein 29 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N6K0.1 GenPept UniProtKB/Swiss-Prot:Q8N6K0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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