SERPINB3 serpin family B member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SERPINB3provided by HGNC
Official Full Name: serpin family B member 3provided by HGNC
Primary source: HGNC:HGNC:10569
See related: Ensembl:ENSG00000057149 MIM:600517; AllianceGenome:HGNC:10569
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SCC; T4-A; SCCA1; SSCA1; SCCA-1; HsT1196; SCCA-PD
Summary: Enables cysteine-type endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Involved in several processes, including autocrine signaling; paracrine signaling; and regulation of cellular protein metabolic process. Located in cytoplasmic vesicle; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward esophagus (RPKM 424.4) See more
Orthologs: all
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Genomic context

Location:: 18q21.33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (63655197..63661893, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (63860279..63866975, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (61322431..61329127, complement)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The polymorphic variant of SerpinB3 (SerpinB3-PD) is associated with faster cirrhosis decompensation.
Title: The polymorphic variant of SerpinB3 (SerpinB3-PD) is associated with faster cirrhosis decompensation.
SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer.
Title: SERPINB3-MYC axis induces the basal-like/squamous subtype and enhances disease progression in pancreatic cancer.
SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease.
Title: SerpinB3 as a Pro-Inflammatory Mediator in the Progression of Experimental Non-Alcoholic Fatty Liver Disease.
Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
Title: Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
The protease-inhibitor SerpinB3 as a critical modulator of the stem-like subset in human cholangiocarcinoma.
Title: The protease-inhibitor SerpinB3 as a critical modulator of the stem-like subset in human cholangiocarcinoma.
Clinical value of MRI, serum SCCA, and CA125 levels in the diagnosis of lymph node metastasis and para-uterine infiltration in cervical cancer.
Title: Clinical value of MRI, serum SCCA, and CA125 levels in the diagnosis of lymph node metastasis and para-uterine infiltration in cervical cancer.
Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-kappaB) Promotes Migration and Invasion of Gastric Cancer Cells.
Title: Upregulation of Serine Proteinase Inhibitor Clade B Member 3 (SERPINB3) Expression by Stromal Cell-Derived Factor (SDF-1)/CXCR4/Nuclear Factor kappa B (NF-κB) Promotes Migration and Invasion of Gastric Cancer Cells.
Autophagy Is Deficient and May be Negatively Regulated by SERPINB3 in Middle Ear Cholesteatoma.
Title: Autophagy Is Deficient and May be Negatively Regulated by SERPINB3 in Middle Ear Cholesteatoma.
Hyperdynamic circulatory syndrome in a mouse model transgenic for SerpinB3.
Title: Hyperdynamic circulatory syndrome in a mouse model transgenic for SerpinB3.
The kinetic profile and clinical implication of SCC-Ag in squamous cervical cancer patients undergoing radical hysterectomy using the Simoa assay: a prospective observational study.
Title: The kinetic profile and clinical implication of SCC-Ag in squamous cervical cancer patients undergoing radical hysterectomy using the Simoa assay: a prospective observational study.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD01269 (e-PCR)
- UniSTS:282376

ECD08500 (e-PCR)
- UniSTS:289548

D18S1028 (e-PCR)
- UniSTS:25874

G15930 (e-PCR)
- UniSTS:60179

ECD19313 (e-PCR)
- UniSTS:300320

ECD02352 (e-PCR)
- UniSTS:283451

RH123576 (e-PCR)
- UniSTS:135996

RH71207 (e-PCR)
- UniSTS:37445

ECD01075 (e-PCR)
- UniSTS:282182

ECD04703 (e-PCR)
- UniSTS:285774

ECD12688 (e-PCR)
- UniSTS:293721

REN10656 (e-PCR)
- UniSTS:335456

REN10658 (e-PCR)
- UniSTS:335458

REN10659 (e-PCR)
- UniSTS:335459

REN10663 (e-PCR)
- UniSTS:335463

REN10666 (e-PCR)
- UniSTS:335466

REN10667 (e-PCR)
- UniSTS:335467

REN10673 (e-PCR)
- UniSTS:335473

REN10681 (e-PCR)
- UniSTS:335481

REN10682 (e-PCR)
- UniSTS:335482

REN10684 (e-PCR)
- UniSTS:335484

REN10686 (e-PCR)
- UniSTS:335486

ECD01651 (e-PCR)
- UniSTS:282752

ECD05786 (e-PCR)
- UniSTS:286848

REN10689 (e-PCR)
- UniSTS:335489

REN10690 (e-PCR)
- UniSTS:335490

ECD20198 (e-PCR)
- UniSTS:301202

ECD21747 (e-PCR)
- UniSTS:302740

REN10731 (e-PCR)
- UniSTS:335531

D18S86 (e-PCR)
- UniSTS:147627

REN10732 (e-PCR)
- UniSTS:335532

REN10733 (e-PCR)
- UniSTS:335533

REN10734 (e-PCR)
- UniSTS:335534

REN10735 (e-PCR)
- UniSTS:335535

REN10736 (e-PCR)
- UniSTS:335536

REN10737 (e-PCR)
- UniSTS:335537

REN10738 (e-PCR)
- UniSTS:335538

REN10739 (e-PCR)
- UniSTS:335539

ECD05580 (e-PCR)
- UniSTS:286643

REN10740 (e-PCR)
- UniSTS:335540

ECD05581 (e-PCR)
- UniSTS:286644

REN10741 (e-PCR)
- UniSTS:335541

REN10742 (e-PCR)
- UniSTS:335542

REN10743 (e-PCR)
- UniSTS:335543

REN10744 (e-PCR)
- UniSTS:335544

REN10745 (e-PCR)
- UniSTS:335545

REN10746 (e-PCR)
- UniSTS:335546

REN10747 (e-PCR)
- UniSTS:335547

REN10748 (e-PCR)
- UniSTS:335548

REN10749 (e-PCR)
- UniSTS:335549

REN10750 (e-PCR)
- UniSTS:335550

REN10751 (e-PCR)
- UniSTS:335551

REN10752 (e-PCR)
- UniSTS:335552

REN10753 (e-PCR)
- UniSTS:335553

REN10754 (e-PCR)
- UniSTS:335554

REN10755 (e-PCR)
- UniSTS:335555

REN10756 (e-PCR)
- UniSTS:335556

REN10757 (e-PCR)
- UniSTS:335557

REN10758 (e-PCR)
- UniSTS:335558

REN10759 (e-PCR)
- UniSTS:335559

REN10760 (e-PCR)
- UniSTS:335560

REN10761 (e-PCR)
- UniSTS:335561

REN10762 (e-PCR)
- UniSTS:335562

REN10763 (e-PCR)
- UniSTS:335563

REN10764 (e-PCR)
- UniSTS:335564

REN10765 (e-PCR)
- UniSTS:335565

REN10766 (e-PCR)
- UniSTS:335566

REN10767 (e-PCR)
- UniSTS:335567

RH17905 (e-PCR)
- UniSTS:82383

stSG619357 (e-PCR)
- UniSTS:453337

ECD06913 (e-PCR)
- UniSTS:287971

ECD12072 (e-PCR)
- UniSTS:293105

ECD23654 (e-PCR)
- UniSTS:304638

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	NAS Non-traceable Author Statement more info	PubMed
enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in autocrine signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in paracrine signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in azurophil granule lumen	TAS Traceable Author Statement more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in vesicle	HDA more info	PubMed

General protein information

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Preferred Names: serpin B3

Names: protein T4-A; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3; serpin peptidase inhibitor, clade B (ovalbumin), member 3; squamous cell carcinoma antigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.