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    INPP4A inositol polyphosphate-4-phosphatase type I A [ Homo sapiens (human) ]

    Gene ID: 3631, updated on 3-Apr-2024

    Summary

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    Official Symbol
    INPP4Aprovided by HGNC
    Official Full Name
    inositol polyphosphate-4-phosphatase type I Aprovided by HGNC
    Primary source
    HGNC:HGNC:6074
    See related
    Ensembl:ENSG00000040933 MIM:600916; AllianceGenome:HGNC:6074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INPP4; TVAS1
    Summary
    This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]
    Expression
    Ubiquitous expression in brain (RPKM 6.3), spleen (RPKM 4.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See INPP4A in Genome Data Viewer
    Location:
    2q11.2
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (98444587..98594392)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (98902886..99052718)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99061050..99210855)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene von Willebrand factor A domain containing 3B Neighboring gene ATP synthase F1 subunit beta pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98896664-98897164 Neighboring gene NANOG hESC enhancer GRCh37_chr2:98933593-98934329 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:98950857-98951787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:98963419-98963930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98993983-98994750 Neighboring gene Sharpr-MPRA regulatory region 13649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:98998693-98999270 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:98999847-99000424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99000425-99001000 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99004561-99004748 Neighboring gene cyclic nucleotide gated channel subunit alpha 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16257 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:99051832-99053031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99079757-99080272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99082317-99082881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99136086-99136586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99136587-99137087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99170837-99171337 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99176784-99176955 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99190711-99190893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99200423-99200924 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99209219-99209372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16269 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99224127-99225116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11802 Neighboring gene cytochrome c oxidase assembly factor 5 Neighboring gene unc-50 inner nuclear membrane RNA binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Whole exome sequencing identified a novel nonsense INPP4A mutation in a family with intellectual disability. Banihashemi S, et al. Eur J Med Genet, 2020 Apr. PMID 31978615
    2. Secretory Inositol Polyphosphate 4-Phosphatase Protects against Airway Inflammation and Remodeling. Khanna K, et al. Am J Respir Cell Mol Biol, 2019 Apr. PMID 30335467, Free PMC Article
    3. Hindbrain malformation and myoclonic seizures associated with a deleterious mutation in the INPP4A gene. Sheffer R, et al. Neurogenetics, 2015 Jan. PMID 25338135
    4. A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma. Sharma M, et al. Am J Respir Crit Care Med, 2008 Apr 1. PMID 18187694
    5. Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene. Shearn CT, et al. Biochem Biophys Res Commun, 2001 Aug 10. PMID 11485317

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps.
      Title: Deficiency of INPP4A promotes M2 macrophage polarization in eosinophilic chronic rhinosinusitis with nasal polyps.
    2. Whole exome sequencing identified a novel nonsense INPP4A mutation in a family with intellectual disability.
      Title: Whole exome sequencing identified a novel nonsense INPP4A mutation in a family with intellectual disability.
    3. miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A).
      Title: miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A).
    4. Low INPP4A expression is associated with cell proliferation, migration, and invasion in colorectal cancer.
      Title: MicroRNA-935 acts as a prognostic marker and promotes cell proliferation, migration, and invasion in colorectal cancer.
    5. INPP4A is secreted by airway epithelial cells and extracellular INPP4A critically inhibits airway inflammation and remodeling.
      Title: Secretory Inositol Polyphosphate 4-Phosphatase Protects against Airway Inflammation and Remodeling.
    6. INPP4A could possibly serve as a candidate gene for alterations associated with asbestos exposure.
      Title: Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing.
    7. Data adds a new etiology to the spectrum of hindbrain malformations in human, and when presented with myoclonic epilepsy may lead to the clinical suspicion of INPP4A defect.
      Title: Hindbrain malformation and myoclonic seizures associated with a deleterious mutation in the INPP4A gene.
    8. INPP4A represents the first signalling protein with a function in neurons to suppress excitotoxic cell death
      Title: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
    9. The +110832A/G (Thr/Ala) variant of INPP4A was significantly associated with asthma in an Indian population.
      Title: A genetic variation in inositol polyphosphate 4 phosphatase a enhances susceptibility to asthma.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association of mood-incongruent psychotic bipolar disorder.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables inositol-1,3,4-trisphosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables inositol-3,4-bisphosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inositol phosphate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in recycling endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol polyphosphate-4-phosphatase type I A
    Names
    inositol polyphosphate-4-phosphatase, type I, 107kD
    inositol polyphosphate-4-phosphatase, type I, 107kDa
    type I inositol 3,4-bisphosphate 4-phosphatase
    NP_001127696.1
    NP_001127697.1
    NP_001338353.1
    NP_001338354.1
    NP_001338355.1
    NP_001338356.1
    NP_001338357.1
    NP_001338358.1
    NP_001557.1
    NP_004018.1
    XP_006712562.1
    XP_006712563.1
    XP_006712564.1
    XP_006712565.1
    XP_006712566.1
    XP_006712568.1
    XP_006712569.1
    XP_011509424.1
    XP_011509425.1
    XP_011509426.1
    XP_011509427.1
    XP_011509429.1
    XP_016859483.1
    XP_016859489.1
    XP_016859490.1
    XP_024308644.1
    XP_047300154.1
    XP_047300155.1
    XP_047300156.1
    XP_047300157.1
    XP_047300159.1
    XP_047300160.1
    XP_047300161.1
    XP_047300162.1
    XP_047300163.1
    XP_047300165.1
    XP_047300166.1
    XP_047300167.1
    XP_047300168.1
    XP_047300169.1
    XP_047300170.1
    XP_047300171.1
    XP_047300173.1
    XP_047300174.1
    XP_054197813.1
    XP_054197814.1
    XP_054197815.1
    XP_054197816.1
    XP_054197817.1
    XP_054197818.1
    XP_054197819.1
    XP_054197820.1
    XP_054197821.1
    XP_054197822.1
    XP_054197823.1
    XP_054197824.1
    XP_054197825.1
    XP_054197826.1
    XP_054197827.1
    XP_054197828.1
    XP_054197829.1
    XP_054197830.1
    XP_054197831.1
    XP_054197832.1
    XP_054197833.1
    XP_054197834.1
    XP_054197835.1
    XP_054197836.1
    XP_054197837.1
    XP_054197838.1
    XP_054197839.1
    XP_054197840.1
    XP_054197841.1
    XP_054197842.1
    XP_054197843.1
    XP_054197844.1
    XP_054197845.1
    XP_054197846.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029890.2 RefSeqGene

      Range
      5273..154807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134224.2 → NP_001127696.1  inositol polyphosphate-4-phosphatase type I A isoform d

      See identical proteins and their annotated locations for NP_001127696.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) uses an alternate, in-frame splice site in the coding region compared to variant a. The resulting isoform (d) is longer but has the same N- and C-termini compared to isoform a.
      Source sequence(s)
      AC010134, AF368319, BC028361
      Consensus CDS
      CCDS46369.1
      UniProtKB/Swiss-Prot
      O15326, Q13187, Q53TD8, Q8TC02, Q96PE3
      UniProtKB/TrEMBL
      A0A9L9PY55
      Related
      ENSP00000427722.1, ENST00000523221.1
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    2. NM_001134225.2 → NP_001127697.1  inositol polyphosphate-4-phosphatase type I A isoform c

      See identical proteins and their annotated locations for NP_001127697.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (c) lacks an alternate exon and uses an alternate, in-frame splice site in the coding region compared to variant a. The resulting isoform (c) is longer but has the same N- and C-termini compared to isoform a.
      Source sequence(s)
      AC010134, BC028361
      Consensus CDS
      CCDS46371.1
      UniProtKB/TrEMBL
      A0A9L9PY55
      Related
      ENSP00000386777.4, ENST00000409851.8
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    3. NM_001351424.1 → NP_001338353.1  inositol polyphosphate-4-phosphatase type I A isoform e

      Status: REVIEWED

      Source sequence(s)
      AC010134
      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    4. NM_001351425.2 → NP_001338354.1  inositol polyphosphate-4-phosphatase type I A isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (f), as well as variant g, encodes isoform f.
      Source sequence(s)
      AC010134
      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    5. NM_001351426.2 → NP_001338355.1  inositol polyphosphate-4-phosphatase type I A isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (g), as well as variant f, encodes isoform f.
      Source sequence(s)
      AC010134
      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    6. NM_001351427.2 → NP_001338356.1  inositol polyphosphate-4-phosphatase type I A isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (h), as well as variant a, encodes isoform a.
      Source sequence(s)
      AC010134
      Consensus CDS
      CCDS46370.1
      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    7. NM_001351428.2 → NP_001338357.1  inositol polyphosphate-4-phosphatase type I A isoform g

      Status: REVIEWED

      Source sequence(s)
      AC010134
      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    8. NM_001351429.2 → NP_001338358.1  inositol polyphosphate-4-phosphatase type I A isoform h

      Status: REVIEWED

      Source sequence(s)
      AC010134
      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    9. NM_001566.2 → NP_001557.1  inositol polyphosphate-4-phosphatase type I A isoform b

      See identical proteins and their annotated locations for NP_001557.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) contains an alternate exon in the 3' coding region and uses a different stop codon compared to variant a. The resulting isoform (b) is longer and has a distint C-terminus compared to isoform a.
      Source sequence(s)
      AC010134, BC028361, U96919
      Consensus CDS
      CCDS46372.1
      UniProtKB/TrEMBL
      A0A9L9PY55
      Related
      ENSP00000387294.3, ENST00000409540.7
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    10. NM_004027.3 → NP_004018.1  inositol polyphosphate-4-phosphatase type I A isoform a

      See identical proteins and their annotated locations for NP_004018.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) encodes the shortest isoform (a). Variants a and h both encode the same isoform (a).
      Source sequence(s)
      AC010134, BC028361, U26398
      Consensus CDS
      CCDS46370.1
      UniProtKB/TrEMBL
      A0A9L9PY55
      Related
      ENSP00000386704.3, ENST00000409016.8
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      98444587..98594392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444199.1 → XP_047300155.1  inositol polyphosphate-4-phosphatase type I A isoform X8

    2. XM_047444209.1 → XP_047300165.1  inositol polyphosphate-4-phosphatase type I A isoform X19

    3. XM_047444204.1 → XP_047300160.1  inositol polyphosphate-4-phosphatase type I A isoform X11

    4. XM_024452876.2 → XP_024308644.1  inositol polyphosphate-4-phosphatase type I A isoform X1

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    5. XM_006712503.4 → XP_006712566.1  inositol polyphosphate-4-phosphatase type I A isoform X6

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    6. XM_047444200.1 → XP_047300156.1  inositol polyphosphate-4-phosphatase type I A isoform X9

    7. XM_017004000.2 → XP_016859489.1  inositol polyphosphate-4-phosphatase type I A isoform X21

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    8. XM_047444201.1 → XP_047300157.1  inositol polyphosphate-4-phosphatase type I A isoform X10

    9. XM_011511124.3 → XP_011509426.1  inositol polyphosphate-4-phosphatase type I A isoform X19

      See identical proteins and their annotated locations for XP_011509426.1

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    10. XM_017004001.2 → XP_016859490.1  inositol polyphosphate-4-phosphatase type I A isoform X22

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    11. XM_047444203.1 → XP_047300159.1  inositol polyphosphate-4-phosphatase type I A isoform X11

    12. XM_047444211.1 → XP_047300167.1  inositol polyphosphate-4-phosphatase type I A isoform X23

    13. XM_006712505.4 → XP_006712568.1  inositol polyphosphate-4-phosphatase type I A isoform X14

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    14. XM_047444206.1 → XP_047300162.1  inositol polyphosphate-4-phosphatase type I A isoform X17

    15. XM_047444210.1 → XP_047300166.1  inositol polyphosphate-4-phosphatase type I A isoform X20

    16. XM_047444214.1 → XP_047300170.1  inositol polyphosphate-4-phosphatase type I A isoform X26

    17. XM_047444205.1 → XP_047300161.1  inositol polyphosphate-4-phosphatase type I A isoform X15

    18. XM_006712499.4 → XP_006712562.1  inositol polyphosphate-4-phosphatase type I A isoform X1

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    19. XM_006712502.4 → XP_006712565.1  inositol polyphosphate-4-phosphatase type I A isoform X4

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    20. XM_006712506.4 → XP_006712569.1  inositol polyphosphate-4-phosphatase type I A isoform X16

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    21. XM_006712500.4 → XP_006712563.1  inositol polyphosphate-4-phosphatase type I A isoform X2

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    22. XM_006712501.4 → XP_006712564.1  inositol polyphosphate-4-phosphatase type I A isoform X3

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    23. XM_047444198.1 → XP_047300154.1  inositol polyphosphate-4-phosphatase type I A isoform X7

    24. XM_017003994.2 → XP_016859483.1  inositol polyphosphate-4-phosphatase type I A isoform X13

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    25. XM_047444207.1 → XP_047300163.1  inositol polyphosphate-4-phosphatase type I A isoform X18

    26. XM_011511122.3 → XP_011509424.1  inositol polyphosphate-4-phosphatase type I A isoform X5

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cl14603
      Location:32 → 142
      C2; C2 domain

    27. XM_011511123.3 → XP_011509425.1  inositol polyphosphate-4-phosphatase type I A isoform X12

      UniProtKB/TrEMBL
      A0A9L9PY55
      Conserved Domains (1) summary
      cd04048
      Location:44 → 157
      C2A_Copine; C2 domain first repeat in Copine

    28. XM_047444212.1 → XP_047300168.1  inositol polyphosphate-4-phosphatase type I A isoform X24

    29. XM_047444213.1 → XP_047300169.1  inositol polyphosphate-4-phosphatase type I A isoform X25

    30. XM_047444215.1 → XP_047300171.1  inositol polyphosphate-4-phosphatase type I A isoform X27

    31. XM_011511125.3 → XP_011509427.1  inositol polyphosphate-4-phosphatase type I A isoform X28

      UniProtKB/TrEMBL
      A0A9L9PY55

    32. XM_047444217.1 → XP_047300173.1  inositol polyphosphate-4-phosphatase type I A isoform X29

    33. XM_047444218.1 → XP_047300174.1  inositol polyphosphate-4-phosphatase type I A isoform X31

    34. XM_011511127.3 → XP_011509429.1  inositol polyphosphate-4-phosphatase type I A isoform X30

    RNA

    1. XR_922915.3 RNA Sequence

    2. XR_007074203.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      98902886..99052718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341846.1 → XP_054197821.1  inositol polyphosphate-4-phosphatase type I A isoform X8

    2. XM_054341850.1 → XP_054197825.1  inositol polyphosphate-4-phosphatase type I A isoform X11

    3. XM_054341839.1 → XP_054197814.1  inositol polyphosphate-4-phosphatase type I A isoform X1

    4. XM_054341844.1 → XP_054197819.1  inositol polyphosphate-4-phosphatase type I A isoform X6

    5. XM_054341847.1 → XP_054197822.1  inositol polyphosphate-4-phosphatase type I A isoform X9

    6. XM_054341861.1 → XP_054197836.1  inositol polyphosphate-4-phosphatase type I A isoform X21

    7. XM_054341848.1 → XP_054197823.1  inositol polyphosphate-4-phosphatase type I A isoform X10

    8. XM_054341859.1 → XP_054197834.1  inositol polyphosphate-4-phosphatase type I A isoform X19

    9. XM_054341862.1 → XP_054197837.1  inositol polyphosphate-4-phosphatase type I A isoform X22

    10. XM_054341849.1 → XP_054197824.1  inositol polyphosphate-4-phosphatase type I A isoform X11

    11. XM_054341863.1 → XP_054197838.1  inositol polyphosphate-4-phosphatase type I A isoform X23

    12. XM_054341853.1 → XP_054197828.1  inositol polyphosphate-4-phosphatase type I A isoform X14

    13. XM_054341854.1 → XP_054197829.1  inositol polyphosphate-4-phosphatase type I A isoform X14

    14. XM_054341857.1 → XP_054197832.1  inositol polyphosphate-4-phosphatase type I A isoform X17

    15. XM_054341860.1 → XP_054197835.1  inositol polyphosphate-4-phosphatase type I A isoform X20

    16. XM_054341866.1 → XP_054197841.1  inositol polyphosphate-4-phosphatase type I A isoform X26

    17. XM_054341855.1 → XP_054197830.1  inositol polyphosphate-4-phosphatase type I A isoform X15

    18. XM_054341838.1 → XP_054197813.1  inositol polyphosphate-4-phosphatase type I A isoform X1

    19. XM_054341842.1 → XP_054197817.1  inositol polyphosphate-4-phosphatase type I A isoform X4

    20. XM_054341856.1 → XP_054197831.1  inositol polyphosphate-4-phosphatase type I A isoform X16

    21. XM_054341840.1 → XP_054197815.1  inositol polyphosphate-4-phosphatase type I A isoform X2

    22. XM_054341841.1 → XP_054197816.1  inositol polyphosphate-4-phosphatase type I A isoform X3

    23. XM_054341845.1 → XP_054197820.1  inositol polyphosphate-4-phosphatase type I A isoform X7

    24. XM_054341852.1 → XP_054197827.1  inositol polyphosphate-4-phosphatase type I A isoform X13

    25. XM_054341858.1 → XP_054197833.1  inositol polyphosphate-4-phosphatase type I A isoform X18

    26. XM_054341843.1 → XP_054197818.1  inositol polyphosphate-4-phosphatase type I A isoform X5

    27. XM_054341851.1 → XP_054197826.1  inositol polyphosphate-4-phosphatase type I A isoform X12

    28. XM_054341864.1 → XP_054197839.1  inositol polyphosphate-4-phosphatase type I A isoform X24

    29. XM_054341865.1 → XP_054197840.1  inositol polyphosphate-4-phosphatase type I A isoform X25

    30. XM_054341867.1 → XP_054197842.1  inositol polyphosphate-4-phosphatase type I A isoform X27

    31. XM_054341868.1 → XP_054197843.1  inositol polyphosphate-4-phosphatase type I A isoform X28

    32. XM_054341869.1 → XP_054197844.1  inositol polyphosphate-4-phosphatase type I A isoform X29

    33. XM_054341871.1 → XP_054197846.1  inositol polyphosphate-4-phosphatase type I A isoform X31

    34. XM_054341870.1 → XP_054197845.1  inositol polyphosphate-4-phosphatase type I A isoform X30

    RNA

    1. XR_008486362.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96PE3.1 GenPept UniProtKB/Swiss-Prot:Q96PE3

    Gene LinkOut

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