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    ADGRF4 adhesion G protein-coupled receptor F4 [ Homo sapiens (human) ]

    Gene ID: 221393, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ADGRF4provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor F4provided by HGNC
    Primary source
    HGNC:HGNC:19011
    See related
    Ensembl:ENSG00000153294 MIM:614268; AllianceGenome:HGNC:19011
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PGR18; GPR115
    Summary
    Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
    Expression
    Biased expression in skin (RPKM 17.6), esophagus (RPKM 6.4) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ADGRF4 in Genome Data Viewer
    Location:
    6p12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (47698580..47722014)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (47540367..47563797)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (47666316..47689750)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CD2 associated protein Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:47589053-47590252 Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene RN7SK pseudogene 116 Neighboring gene ribosomal protein L27a pseudogene 7 Neighboring gene opsin 5 Neighboring gene RNA, U1 small nuclear 105, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma. Nishiwada S, et al. Br J Cancer, 2023 Jan. PMID 36396823, Free PMC Article
    2. Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions. Fredriksson R, et al. FEBS Lett, 2002 Nov 20. PMID 12435584
    3. Exome sequencing supports a de novo mutational paradigm for schizophrenia. Xu B, et al. Nat Genet, 2011 Aug 7. PMID 21822266, Free PMC Article
    4. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
    5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma.
      Title: Clinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: ADGRF2

    Homology

    Clone Names

    • FLJ38076

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor F4
    Names
    G-protein coupled receptor PGR18
    probable G-protein coupled receptor 115
    seven transmembrane helix receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052799.1 RefSeqGene

      Range
      17682..41158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001347855.2 → NP_001334784.1  adhesion G protein-coupled receptor F4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK095395, AY140957, BU683873
      Consensus CDS
      CCDS4922.2
      UniProtKB/Swiss-Prot
      B3KTD0, Q2PNZ0, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6, Q8IZF3
      UniProtKB/TrEMBL
      A0A0C4DFV3
      Related
      ENSP00000328319.3, ENST00000327753.7

    2. NM_153838.5 → NP_722580.3  adhesion G protein-coupled receptor F4 precursor

      See identical proteins and their annotated locations for NP_722580.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AY255556, BU683873, DB313938, DQ315370
      Consensus CDS
      CCDS4922.2
      UniProtKB/Swiss-Prot
      B3KTD0, Q2PNZ0, Q5T5B5, Q5T5B6, Q86SN9, Q8IXE6, Q8IZF3
      UniProtKB/TrEMBL
      A0A0C4DFV3
      Related
      ENSP00000283303.2, ENST00000283303.3
      Conserved Domains (2) summary
      pfam01825
      Location:347 → 390
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:400 → 648
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      47698580..47722014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      47540367..47563797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZF3.3 GenPept UniProtKB/Swiss-Prot:Q8IZF3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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