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    EML5 EMAP like 5 [ Homo sapiens (human) ]

    Gene ID: 161436, updated on 5-Mar-2024

    Summary

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    Official Symbol
    EML5provided by HGNC
    Official Full Name
    EMAP like 5provided by HGNC
    Primary source
    HGNC:HGNC:18197
    See related
    Ensembl:ENSG00000165521 MIM:618119; AllianceGenome:HGNC:18197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAP16; EMAP-2; EMAP-5
    Summary
    Predicted to enable microtubule binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary (RPKM 10.1), prostate (RPKM 3.2) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    14q31.3
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (88612431..88792953, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (82833321..83016566, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (89078775..89259297, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370614 Neighboring gene protein tyrosine phosphatase non-receptor type 21 Neighboring gene RNA, U4 small nuclear 22, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:89015655-89016472 Neighboring gene proline-rich protein 2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5992 Neighboring gene zinc finger CCCH-type containing 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8842 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:89084698-89085319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8843 Neighboring gene MPRA-validated peak2226 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8844 Neighboring gene RNA, U4 small nuclear 92, pseudogene Neighboring gene tetratricopeptide repeat domain 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Eml5, a novel WD40 domain protein expressed in rat brain. O'Connor V, et al. Gene, 2004 Jul 7. PMID 15225882
    2. Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase. Kim TY, et al. Mol Cell Biol, 2015 Jan. PMID 25332235, Free PMC Article
    3. Cullin 1 (CUL1) Promotes Primary Ciliogenesis through the Induction of Ubiquitin-Proteasome-Dependent Dvl2 Degradation. Kim SO, et al. Int J Mol Sci, 2021 Jul 15. PMID 34299191, Free PMC Article
    4. A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase. Low TY, et al. Sci Signal, 2014 Dec 16. PMID 25515538
    5. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781D1122

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    echinoderm microtubule-associated protein-like 5
    Names
    echinoderm microtubule associated protein like 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385116.1 → NP_001372045.1  echinoderm microtubule-associated protein-like 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL121768, AL162171
      Conserved Domains (4) summary
      COG2319
      Location:1403 → 1811
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      cl29593
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001385117.1 → NP_001372046.1  echinoderm microtubule-associated protein-like 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL121768
      Conserved Domains (3) summary
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      cl29593
      Location:725 → 1026
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001411033.1 → NP_001397962.1  echinoderm microtubule-associated protein-like 5 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL121768, AL162171
      Consensus CDS
      CCDS91916.1
      UniProtKB/Swiss-Prot
      B9EK59, Q05BV3, Q5H9N6, Q6UYC9, Q6ZRP3, Q6ZT03
      Related
      ENSP00000370039.5, ENST00000380664.9

    4. NM_183387.3 → NP_899243.1  echinoderm microtubule-associated protein-like 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL121768, AL162171, BC032685, BC042055, BC150639
      Consensus CDS
      CCDS45148.1
      UniProtKB/Swiss-Prot
      Q05BV3
      Related
      ENSP00000451998.1, ENST00000554922.6
      Conserved Domains (4) summary
      COG2319
      Location:353 → 843
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      88612431..88792953 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431057.1 → XP_047287013.1  echinoderm microtubule-associated protein-like 5 isoform X15

    2. XM_017021065.3 → XP_016876554.1  echinoderm microtubule-associated protein-like 5 isoform X8

    3. XM_047431056.1 → XP_047287012.1  echinoderm microtubule-associated protein-like 5 isoform X9

    4. XM_017021066.3 → XP_016876555.1  echinoderm microtubule-associated protein-like 5 isoform X11

    5. XM_011536533.4 → XP_011534835.1  echinoderm microtubule-associated protein-like 5 isoform X10

      Conserved Domains (4) summary
      COG2319
      Location:353 → 891
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      sd00039
      Location:775 → 814
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:725 → 1025
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_017021064.3 → XP_016876553.1  echinoderm microtubule-associated protein-like 5 isoform X7

    7. XM_011536531.4 → XP_011534833.1  echinoderm microtubule-associated protein-like 5 isoform X5

      Conserved Domains (4) summary
      COG2319
      Location:353 → 843
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_011536530.4 → XP_011534832.1  echinoderm microtubule-associated protein-like 5 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:353 → 843
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_017021063.3 → XP_016876552.1  echinoderm microtubule-associated protein-like 5 isoform X4

    10. XM_017021068.3 → XP_016876557.1  echinoderm microtubule-associated protein-like 5 isoform X13

    11. XM_011536532.4 → XP_011534834.1  echinoderm microtubule-associated protein-like 5 isoform X6

      Conserved Domains (4) summary
      COG2319
      Location:353 → 843
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    12. XM_017021062.3 → XP_016876551.1  echinoderm microtubule-associated protein-like 5 isoform X3

    13. XM_011536528.4 → XP_011534830.1  echinoderm microtubule-associated protein-like 5 isoform X1

      Conserved Domains (4) summary
      COG2319
      Location:353 → 843
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    14. XM_017021067.3 → XP_016876556.1  echinoderm microtubule-associated protein-like 5 isoform X12

    15. XM_011536534.4 → XP_011534836.1  echinoderm microtubule-associated protein-like 5 isoform X14

      Conserved Domains (4) summary
      COG2319
      Location:294 → 784
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:612 → 655
      HELP; HELP motif
      sd00039
      Location:7 → 45
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:666 → 1004
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    16. XM_017021069.3 → XP_016876558.1  echinoderm microtubule-associated protein-like 5 isoform X14

      Conserved Domains (4) summary
      COG2319
      Location:294 → 784
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:612 → 655
      HELP; HELP motif
      sd00039
      Location:7 → 45
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:666 → 1004
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    17. XM_047431060.1 → XP_047287016.1  echinoderm microtubule-associated protein-like 5 isoform X20

    18. XM_011536536.3 → XP_011534838.1  echinoderm microtubule-associated protein-like 5 isoform X17

      Conserved Domains (4) summary
      COG2319
      Location:353 → 843
      WD40; WD40 repeat [General function prediction only]
      pfam03451
      Location:5 → 47
      HELP; HELP motif
      sd00039
      Location:64 → 104
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:725 → 1063
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    19. XM_047431058.1 → XP_047287014.1  echinoderm microtubule-associated protein-like 5 isoform X16

    20. XM_017021070.2 → XP_016876559.1  echinoderm microtubule-associated protein-like 5 isoform X18

    21. XM_047431059.1 → XP_047287015.1  echinoderm microtubule-associated protein-like 5 isoform X19

    22. XM_047431061.1 → XP_047287017.1  echinoderm microtubule-associated protein-like 5 isoform X21

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      82833321..83016566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375531.1 → XP_054231506.1  echinoderm microtubule-associated protein-like 5 isoform X15

    2. XM_054375523.1 → XP_054231498.1  echinoderm microtubule-associated protein-like 5 isoform X8

    3. XM_054375524.1 → XP_054231499.1  echinoderm microtubule-associated protein-like 5 isoform X9

    4. XM_054375526.1 → XP_054231501.1  echinoderm microtubule-associated protein-like 5 isoform X11

    5. XM_054375525.1 → XP_054231500.1  echinoderm microtubule-associated protein-like 5 isoform X10

    6. XM_054375522.1 → XP_054231497.1  echinoderm microtubule-associated protein-like 5 isoform X7

    7. XM_054375520.1 → XP_054231495.1  echinoderm microtubule-associated protein-like 5 isoform X5

    8. XM_054375517.1 → XP_054231492.1  echinoderm microtubule-associated protein-like 5 isoform X2

    9. XM_054375519.1 → XP_054231494.1  echinoderm microtubule-associated protein-like 5 isoform X4

    10. XM_054375528.1 → XP_054231503.1  echinoderm microtubule-associated protein-like 5 isoform X13

    11. XM_054375521.1 → XP_054231496.1  echinoderm microtubule-associated protein-like 5 isoform X6

    12. XM_054375518.1 → XP_054231493.1  echinoderm microtubule-associated protein-like 5 isoform X3

    13. XM_054375516.1 → XP_054231491.1  echinoderm microtubule-associated protein-like 5 isoform X1

    14. XM_054375527.1 → XP_054231502.1  echinoderm microtubule-associated protein-like 5 isoform X12

    15. XM_054375530.1 → XP_054231505.1  echinoderm microtubule-associated protein-like 5 isoform X14

    16. XM_054375529.1 → XP_054231504.1  echinoderm microtubule-associated protein-like 5 isoform X14

    17. XM_054375536.1 → XP_054231511.1  echinoderm microtubule-associated protein-like 5 isoform X20

    18. XM_054375533.1 → XP_054231508.1  echinoderm microtubule-associated protein-like 5 isoform X17

    19. XM_054375532.1 → XP_054231507.1  echinoderm microtubule-associated protein-like 5 isoform X16

    20. XM_054375534.1 → XP_054231509.1  echinoderm microtubule-associated protein-like 5 isoform X18

    21. XM_054375535.1 → XP_054231510.1  echinoderm microtubule-associated protein-like 5 isoform X19

    22. XM_054375537.1 → XP_054231512.1  echinoderm microtubule-associated protein-like 5 isoform X21

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05BV3.3 GenPept UniProtKB/Swiss-Prot:Q05BV3

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