NAP1L1 nucleosome assembly protein 1 like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NAP1L1provided by HGNC
Official Full Name: nucleosome assembly protein 1 like 1provided by HGNC
Primary source: HGNC:HGNC:7637
See related: Ensembl:ENSG00000187109 MIM:164060; AllianceGenome:HGNC:7637
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NRP; NAP1; NAP1L
Summary: This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]
Expression: Ubiquitous expression in ovary (RPKM 100.8), lymph node (RPKM 74.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q21.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (76036585..76084685, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (76011669..76059726, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (76430365..76478465, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility.
Title: Nucleosome assembly protein 1-like 1 (NAP1L1) in gastric cancer patients: a potential biomarker with diagnostic and prognostic utility.
Dynamic Solution Structures of Whole Human NAP1 Dimer Bound to One and Two Histone H2A-H2B Heterodimers Obtained by Integrative Methods.
Title: Dynamic Solution Structures of Whole Human NAP1 Dimer Bound to One and Two Histone H2A-H2B Heterodimers Obtained by Integrative Methods.
A New Role of NAP1L1 in Megakaryocytes and Human Platelets.
Title: A New Role of NAP1L1 in Megakaryocytes and Human Platelets.
NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer.
Title: NAP1L1 promotes tumor proliferation through HDGF/C-JUN signaling in ovarian cancer.
NAP1L1 targeting suppresses the proliferation of nasopharyngeal carcinoma.
Title: NAP1L1 targeting suppresses the proliferation of nasopharyngeal carcinoma.
Prognostic significance of NAP1L1 expression in patients with early lung adenocarcinoma.
Title: Prognostic significance of NAP1L1 expression in patients with early lung adenocarcinoma.
The NAP1L1 regulates cell fate by controlling the expression of p53-responsive proarrest and proapoptotic genes through selective modulation of p53 acetylation at specific sites during normal homeostasis and in stress-induced responses.
Title: Nucleosome assembly proteins NAP1L1 and NAP1L4 modulate p53 acetylation to regulate cell fate.
Through regulating NAP1L1, PRDM8 inhibits PI3K/AKT/mTOR signaling in hepatocellular carcinoma.
Title: PRDM8 exhibits antitumor activities toward hepatocellular carcinoma by targeting NAP1L1.
Long non-coding RNAs (lncRNAs) CDKN2B-AS1 promoted nucleosome assembly protein 1 like 1 (NAP1L1) expression by sponging let-7c-5p in hepatocellular carcinoma (HCC) cells.
Title: LncRNA CDKN2B-AS1 promotes tumor growth and metastasis of human hepatocellular carcinoma by targeting let-7c-5p/NAP1L1 axis.
Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.
Title: Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-ordered chromatin containing histone H1.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	HIV-1 Rev interacting protein, nucleosome assembly protein 1-like 1 (NAP1L1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with NAP1L1 is decreased by RRE	PubMed
	rev	HIV-1 Rev interacts with nucleosome assembly protein 1 (Nap1) in cells and this interaction involves amino acid residues 41-51 in Rev. Nap1 modulates the nuclear import of Rev	PubMed
Tat	tat	NAP1 co-localizes with HIV-1 Tat at the nuclear rim and is required for the transport of Tat within the nucleus rather than for the remodeling of nucleosomes on the provirus	PubMed
	tat	HIV-1 Tat, NAP-1, and p300 synergistically activate HIV-1 transcription	PubMed
	tat	NAP-1 interacts with HIV-1 Tat, leading to cooperative activation of HIV-1 gene expression. Residues 162-391 of NAP-1 and residues 49-57 of Tat are involved in the interaction	PubMed
	tat	NAP1 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed
nucleocapsid	gag	Nucleosome assembly protein 1-like 1 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-T91337 (e-PCR)
- UniSTS:6400

D14S655E (e-PCR)
- UniSTS:151553

D12S2017 (e-PCR)
- UniSTS:65797

RH44713 (e-PCR)
- UniSTS:22033

G19743 (e-PCR)
- UniSTS:54557

A001X15 (e-PCR)
- UniSTS:54558

SGC32694 (e-PCR)
- UniSTS:45858

G19924 (e-PCR)
- UniSTS:55639

D12S1660 (e-PCR), detects polymorphism
- UniSTS:59746

D12S1919 (e-PCR)
- UniSTS:28538

G64775 (e-PCR)
- UniSTS:164743

SHGC-82158 (e-PCR)
- UniSTS:103071

SHGC-2539 (e-PCR)
- UniSTS:46270

RH68239 (e-PCR)
- UniSTS:83662

RH66860 (e-PCR)
- UniSTS:89816

RH47552 (e-PCR)
- UniSTS:92640

G60591 (e-PCR)
- UniSTS:137697

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	TAS Traceable Author Statement more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nucleosome assembly protein 1-like 1

Names: HSP22-like protein interacting protein; NAP-1-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001307924.3 → NP_001294853.1 nucleosome assembly protein 1-like 1 isoform 2

See identical proteins and their annotated locations for NP_001294853.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two exons in the 3' coding region and includes an alternate 3' terminal exon, compared to variant 2. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC011611, AK295147, AL162068, BF666587, BM929581, BU183927, DA512918, HY300507

Consensus CDS

CCDS76581.1

UniProtKB/TrEMBL

B7Z2V4, F5H4R6

Related

ENSP00000445008.2, ENST00000535020.6

Conserved Domains (1) summary

pfam00956
Location:76 → 344

NAP; Nucleosome assembly protein (NAP)
NM_001330231.2 → NP_001317160.1 nucleosome assembly protein 1-like 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 4 encode the same isoform (1).

Source sequence(s)

AA057019, AC011611, AF300335, AL162068, AW950481, BU183927, CD000987, CD678271, CX870413, DA137494, DA512918, DB546929, M86667

Consensus CDS

CCDS9013.1

UniProtKB/Swiss-Prot

B3KNT8, B3KV44, P55209

UniProtKB/TrEMBL

H0YIV4

Related

ENSP00000450236.1, ENST00000552056.5

Conserved Domains (1) summary

pfam00956
Location:76 → 343

NAP; Nucleosome assembly protein (NAP)
NM_001330232.2 → NP_001317161.1 nucleosome assembly protein 1-like 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two consecutive in-frame exons in the 5' coding region and differs in the 3' UTR compared to variant 2. The encoded isoform (3) is shorter, but has the same N- and C-termini as isoform 1.

Source sequence(s)

AA057019, AC011611, AF300335, AL162068, AW950481, CD000987, CD678271, DA137494, DA344092, DA512918, DB546929, M86667

Consensus CDS

CCDS81715.1

UniProtKB/TrEMBL

F8W543, H0YIV4

Related

ENSP00000444759.1, ENST00000542344.5

Conserved Domains (1) summary

pfam00956
Location:13 → 280

NAP; Nucleosome assembly protein (NAP)
NM_004537.7 → NP_004528.1 nucleosome assembly protein 1-like 1 isoform 1

See identical proteins and their annotated locations for NP_004528.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 4 encode the same isoform (1).

Source sequence(s)

AA057019, AC011611, AF300335, AL162068, AW950481, BU183927, CD000987, CD678271, DA137494, DA512918, DB546929

Consensus CDS

CCDS9013.1

UniProtKB/Swiss-Prot

B3KNT8, B3KV44, P55209

UniProtKB/TrEMBL

H0YIV4

Related

ENSP00000477538.1, ENST00000618691.5

Conserved Domains (1) summary

pfam00956
Location:76 → 343

NAP; Nucleosome assembly protein (NAP)
NM_139207.5 → NP_631946.1 nucleosome assembly protein 1-like 1 isoform 1

See identical proteins and their annotated locations for NP_631946.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 3' UTR compared to variant 2. Variants 1, 2 and 4 encode the same isoform (1).

Source sequence(s)

AA057019, AC011611, AF300335, AL162068, AW950481, BU183927, CD000987, CD678271, DA137494, DA512918, DB546929, M86667

Consensus CDS

CCDS9013.1

UniProtKB/Swiss-Prot

B3KNT8, B3KV44, P55209

UniProtKB/TrEMBL

H0YIV4

Related

ENSP00000376947.3, ENST00000393263.7

Conserved Domains (1) summary

pfam00956
Location:76 → 343

NAP; Nucleosome assembly protein (NAP)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

76036585..76084685 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024448983.2 → XP_024304751.1 nucleosome assembly protein 1-like 1 isoform X2

UniProtKB/TrEMBL

F8W543, H0YIV4

Related

ENSP00000448167.1, ENST00000547773.5

Conserved Domains (1) summary

pfam00956
Location:13 → 280

NAP; Nucleosome assembly protein (NAP)
XM_047428879.1 → XP_047284835.1 nucleosome assembly protein 1-like 1 isoform X2

UniProtKB/TrEMBL

F8W543
XM_017019340.3 → XP_016874829.1 nucleosome assembly protein 1-like 1 isoform X2

UniProtKB/TrEMBL

F8W543, H0YIV4

Conserved Domains (1) summary

pfam00956
Location:13 → 280

NAP; Nucleosome assembly protein (NAP)
XM_011538393.3 → XP_011536695.1 nucleosome assembly protein 1-like 1 isoform X1

See identical proteins and their annotated locations for XP_011536695.1

UniProtKB/Swiss-Prot

B3KNT8, B3KV44, P55209

UniProtKB/TrEMBL

H0YIV4

Conserved Domains (1) summary

pfam00956
Location:76 → 343

NAP; Nucleosome assembly protein (NAP)

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

76011669..76059726 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372110.1 → XP_054228085.1 nucleosome assembly protein 1-like 1 isoform X2

UniProtKB/TrEMBL

F8W543
XM_054372111.1 → XP_054228086.1 nucleosome assembly protein 1-like 1 isoform X2

UniProtKB/TrEMBL

F8W543