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2007 1
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Page 1
Safety of isotretinoin treatment as measured by liver parameters.
Thomazini BF, Lamas CA, Dolder MAH. Thomazini BF, et al. Histol Histopathol. 2019 Jul;34(7):755-763. doi: 10.14670/HH-18-075. Epub 2018 Dec 17. Histol Histopathol. 2019. PMID: 30556579
The changes observed with the 10 mg/kg dose were not conclusive for liver damage, because of the lack of histological structural modifications and the few biochemical alterations. The 1 mg/kg dose showed a liver responding to some stimuli but without profound altera …
The changes observed with the 10 mg/kg dose were not conclusive for liver damage, because of the lack of histological structural modi …
Dietary Supplements, Isotretinoin, and Liver Toxicity in Adolescents: A Retrospective Case Series.
DeKlotz CMC, Roby KD, Friedlander SF. DeKlotz CMC, et al. Pediatrics. 2017 Oct;140(4):e20152940. doi: 10.1542/peds.2015-2940. Epub 2017 Sep 1. Pediatrics. 2017. PMID: 28864554
However, little is known about the effects of protein supplements on the liver, particularly in patients taking isotretinoin. We designed a retrospective chart review to evaluate the symptoms, diagnosis, treatment, and outcome of patients on or preparing to take isotretino …
However, little is known about the effects of protein supplements on the liver, particularly in patients taking isotretinoin. We desi …
Standardized laboratory monitoring with use of isotretinoin in acne.
Hansen TJ, Lucking S, Miller JJ, Kirby JS, Thiboutot DM, Zaenglein AL. Hansen TJ, et al. J Am Acad Dermatol. 2016 Aug;75(2):323-8. doi: 10.1016/j.jaad.2016.03.019. Epub 2016 May 14. J Am Acad Dermatol. 2016. PMID: 27189824
RESULTS: Clinically insignificant leukopenia or thrombocytopenia occurred in 1.4% and 0.9% of patients, respectively. Elevated liver transaminases were detected infrequently and not significantly increased compared with baseline detection rates (1.9% vs 1.6% at baseline). …
RESULTS: Clinically insignificant leukopenia or thrombocytopenia occurred in 1.4% and 0.9% of patients, respectively. Elevated liver …
The effect of isotretinoin on biotinidase activity.
Schulpis KH, Georgala S, Papakonstantinou ED, Michas T, Karikas GA. Schulpis KH, et al. Skin Pharmacol Appl Skin Physiol. 1999 Jan-Apr;12(1-2):28-33. doi: 10.1159/000029843. Skin Pharmacol Appl Skin Physiol. 1999. PMID: 10325581 Clinical Trial.
Moreover, the effect of isotretinoin on a known plasma biotinidase activity was evaluated after incubation in vitro with various concentrations of the drug. RESULTS: A statistically significant elevation of liver enzymes and lipids, except high density lipoprotein, …
Moreover, the effect of isotretinoin on a known plasma biotinidase activity was evaluated after incubation in vitro with various concentrati …
Hepatic toxicity of vitamin A and synthetic retinoids.
Fallon MB, Boyer JL. Fallon MB, et al. J Gastroenterol Hepatol. 1990 May-Jun;5(3):334-42. doi: 10.1111/j.1440-1746.1990.tb01635.x. J Gastroenterol Hepatol. 1990. PMID: 2103414 Review.
Isotretinoin therapy for acne vulgaris: a re-evaluation of the need for measurements of plasma lipids and liver function tests.
Barth JH, Macdonald-Hull SP, Mark J, Jones RG, Cunliffe WJ. Barth JH, et al. Br J Dermatol. 1993 Dec;129(6):704-7. doi: 10.1111/j.1365-2133.1993.tb03336.x. Br J Dermatol. 1993. PMID: 8286255
In conclusion, there appears to be little evidence to support the previously recommended regular biochemical monitoring of liver function and lipid profiles in patients who are treated with isotretinoin for 16 weeks. It would appear prudent to ensure that there is neither …
In conclusion, there appears to be little evidence to support the previously recommended regular biochemical monitoring of liver func …
Systemic retinoids in the management of ichthyoses and related skin types.
Digiovanna JJ, Mauro T, Milstone LM, Schmuth M, Toro JR. Digiovanna JJ, et al. Dermatol Ther. 2013 Jan-Feb;26(1):26-38. doi: 10.1111/j.1529-8019.2012.01527.x. Dermatol Ther. 2013. PMID: 23384018 Free PMC article.
Early use of high-dose vitamin A demonstrated efficacy, but because vitamin A is stored in the liver, toxicity limited usefulness. Interest turned to synthetic retinoids in an effort to enhance efficacy and limit toxicity. ...
Early use of high-dose vitamin A demonstrated efficacy, but because vitamin A is stored in the liver, toxicity limited usefulness. In …
21 results