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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 3
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1963 1
1964 3
1965 6
1966 9
1967 9
1968 4
1969 6
1970 7
1971 6
1972 8
1973 7
1974 4
1975 4
1976 2
1977 3
1978 4
1979 3
1980 4
1981 4
1982 2
1983 1
1984 2
1985 3
1986 1
1988 2
1989 3
1990 2
1993 1
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1996 1
2001 1
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2012 1
2013 3
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2024 0

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139 results

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Page 1
Drug-induced hepatotoxicity.
Kaplowitz N, Aw TY, Simon FR, Stolz A. Kaplowitz N, et al. Ann Intern Med. 1986 Jun;104(6):826-39. doi: 10.7326/0003-4819-104-6-826. Ann Intern Med. 1986. PMID: 3518564 Review.
Drug-induced injury to the liver can mimic any form of acute or chronic liver disease. ...Certain drugs produce chronic liver disease that is pathologically identical to chronic active hepatitis, biliary cirrhosis, or alcoholic liver …
Drug-induced injury to the liver can mimic any form of acute or chronic liver disease. ...Certain drugs p …
Mouse precision-cut liver slices as an ex vivo model to study drug-induced cholestasis.
Karsten REH, Krijnen NJW, Maho W, Permentier H, Verpoorte E, Olinga P. Karsten REH, et al. Arch Toxicol. 2022 Sep;96(9):2523-2543. doi: 10.1007/s00204-022-03321-2. Epub 2022 Jun 16. Arch Toxicol. 2022. PMID: 35708773 Free PMC article.
Drugs are often withdrawn from the market due to the manifestation of drug-induced liver injury (DILI) in patients. Drug-induced cholestasis (DIC), defined as obstruction of hepatic bile flow due to medication, is one form of DILI. Becaus …
Drugs are often withdrawn from the market due to the manifestation of drug-induced liver injury (DILI) in patien …
Drug-induced liver disease.
Holzbach RT. Holzbach RT. Prim Care. 1981 Jun;8(2):231-50. Prim Care. 1981. PMID: 7027290 Review.
The various forms and manifestations of drug-induced liver disease depend on the operation and interaction of several potential factors. ...The microsomal membranes and the MFO enzymes are capable of induction (increase in structure and function). Second, for …
The various forms and manifestations of drug-induced liver disease depend on the operation and interaction of several p …
Validation of precision-cut liver slices to study drug-induced cholestasis: a transcriptomics approach.
Vatakuti S, Olinga P, Pennings JLA, Groothuis GMM. Vatakuti S, et al. Arch Toxicol. 2017 Mar;91(3):1401-1412. doi: 10.1007/s00204-016-1778-8. Epub 2016 Jun 25. Arch Toxicol. 2017. PMID: 27344345 Free PMC article.
Therefore, there is a need to screen new drugs for hepatotoxicity in humans at an earlier stage. The aim of this study was to validate human precision-cut liver slices (PCLS) as an ex vivo model to predict drug-induced cholestasis and identify the possible me …
Therefore, there is a need to screen new drugs for hepatotoxicity in humans at an earlier stage. The aim of this study was to validate human …
Impact of inflammation on chlorpromazine-induced cytotoxicity and cholestatic features in HepaRG cells.
Bachour-El Azzi P, Sharanek A, Abdel-Razzak Z, Antherieu S, Al-Attrache H, Savary CC, Lepage S, Morel I, Labbe G, Guguen-Guillouzo C, Guillouzo A. Bachour-El Azzi P, et al. Drug Metab Dispos. 2014 Sep;42(9):1556-66. doi: 10.1124/dmd.114.058123. Epub 2014 Jul 7. Drug Metab Dispos. 2014. PMID: 25002748
Several factors are thought to be implicated in the occurrence of idiosyncratic adverse drug reactions. The present work aimed to question as to whether inflammation is a determinant factor in hepatic lesions induced by chlorpromazine (CPZ) using the human HepaRG ce …
Several factors are thought to be implicated in the occurrence of idiosyncratic adverse drug reactions. The present work aimed to que …
Drug-induced immunological effects on the liver.
Davies GE, Holmes JE. Davies GE, et al. Br J Anaesth. 1972 Sep;44(9):941-5. doi: 10.1093/bja/44.9.941. Br J Anaesth. 1972. PMID: 4264065 Free article. Review. No abstract available.
Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices.
Vatakuti S, Pennings JL, Gore E, Olinga P, Groothuis GM. Vatakuti S, et al. Chem Res Toxicol. 2016 Mar 21;29(3):342-51. doi: 10.1021/acs.chemrestox.5b00491. Epub 2016 Mar 9. Chem Res Toxicol. 2016. PMID: 26881866
Human toxicity screening is an important stage in the development of safe drug candidates. Hepatotoxicity is one of the major reasons for the withdrawal of drugs from the market because the liver is the major organ involved in drug metabolism, and it can gene …
Human toxicity screening is an important stage in the development of safe drug candidates. Hepatotoxicity is one of the major reasons …
Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity.
Xuan J, Chen S, Ning B, Tolleson WH, Guo L. Xuan J, et al. Chem Biol Interact. 2016 Aug 5;255:63-73. doi: 10.1016/j.cbi.2015.10.009. Epub 2015 Oct 22. Chem Biol Interact. 2016. PMID: 26477383 Free PMC article.
The generation of reactive metabolites from therapeutic agents is one of the major mechanisms of drug-induced liver injury (DILI). In order to evaluate metabolism-related toxicity and improve drug efficacy and safety, we generated a battery of H …
The generation of reactive metabolites from therapeutic agents is one of the major mechanisms of drug-induced liver …
Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.
Anthérieu S, Bachour-El Azzi P, Dumont J, Abdel-Razzak Z, Guguen-Guillouzo C, Fromenty B, Robin MA, Guillouzo A. Anthérieu S, et al. Hepatology. 2013 Apr;57(4):1518-29. doi: 10.1002/hep.26160. Epub 2013 Mar 4. Hepatology. 2013. PMID: 23175273
Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigated using the differentiated human hepatoma HepaRG cells. ...CONCLUSION: These data provide evidence that, among other mechanisms, oxidative …
Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce intrahepatic cholestasis, were investigat …
139 results