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Samarcandin protects against testicular ischemia/reperfusion injury in rats via activation of Nrf2/HO-1-mediated antioxidant responses.
Abdel-Kader MS, Abdel-Rahman RF, Althurwi HN, Soliman GA, Ogaly HA, Albaqami FF. Abdel-Kader MS, et al. Saudi Pharm J. 2023 Jul;31(7):1186-1196. doi: 10.1016/j.jsps.2023.05.007. Epub 2023 May 12. Saudi Pharm J. 2023. PMID: 37273262 Free PMC article.
The purpose of this study was to evaluate the effectiveness of samarcandin (SMR) in preventing testicular injury caused by ischemia/reperfusion (I/R) in rats. ...
The purpose of this study was to evaluate the effectiveness of samarcandin (SMR) in preventing testicular injury caused by ischemia/r …
Sesquiterpene Coumarin Ethers with Selective Cytotoxic Activities from the Roots of Ferula huber-morathii Pesmen (Apiaceae) and Unequivocal Determination of the Absolute Stereochemistry of Samarcandin.
Eruçar FM, Kuran FK, Altıparmak Ülbegi G, Özbey S, Karavuş ŞN, Arcan GG, Yazıcı Tütüniş S, Tan N, Aksoy Sağırlı P, Miski M. Eruçar FM, et al. Pharmaceuticals (Basel). 2023 May 26;16(6):792. doi: 10.3390/ph16060792. Pharmaceuticals (Basel). 2023. PMID: 37375740 Free PMC article.
Extensive spectroscopic analyses and chemical transformations have elucidated the structures of these sesquiterpene coumarin ethers as conferone (1), conferol (2), feselol (3), badrakemone (4), mogoltadone (5), farnesiferol A (6), farnesiferol A acetate (7), gummosin (8), ferukri …
Extensive spectroscopic analyses and chemical transformations have elucidated the structures of these sesquiterpene coumarin ethers as confe …
NMR-based metabolomic study of asafoetida.
Farhadi F, Asili J, Iranshahy M, Iranshahi M. Farhadi F, et al. Fitoterapia. 2019 Nov;139:104361. doi: 10.1016/j.fitote.2019.104361. Epub 2019 Oct 17. Fitoterapia. 2019. PMID: 31629871
The distinguished metabolites, umbelliprenin, farnesiferol B, farnesiferol C, samarcandin and galbanic acid are significantly found in southern samples. ...
The distinguished metabolites, umbelliprenin, farnesiferol B, farnesiferol C, samarcandin and galbanic acid are significantly found i …
Isolation, spectroscopic characterization, X-ray, theoretical studies as well as in vitro cytotoxicity of Samarcandin.
Ghoran SH, Atabaki V, Babaei E, Olfatkhah SR, Dusek M, Eigner V, Soltani A, Khalaji AD. Ghoran SH, et al. Bioorg Chem. 2016 Jun;66:27-32. doi: 10.1016/j.bioorg.2016.03.005. Epub 2016 Mar 15. Bioorg Chem. 2016. PMID: 26998943
Samarcandin 1, a natural sesquiterpene-coumarin, was isolated as well as elucidated from F. assa-foetida which has significant effect in Iranian traditional medicine because of its medicinal attitudes. The crystal structure of samarcandin was determined by single-cr …
Samarcandin 1, a natural sesquiterpene-coumarin, was isolated as well as elucidated from F. assa-foetida which has significant effect …
Anti-quorum sensing and antibiofilm activity of coumarin derivatives against Pseudomonas aeruginosa PAO1: Insights from in vitro and in silico studies.
Tajani AS, Amiri Tehranizadeh Z, Pourmohammad A, Pourmohammad A, Iranshahi M, Farhadi F, Soheili V, Fazly Bazzaz BS. Tajani AS, et al. Iran J Basic Med Sci. 2023 Apr;26(4):445-452. doi: 10.22038/IJBMS.2023.69016.15047. Iran J Basic Med Sci. 2023. PMID: 37009015 Free PMC article.
MATERIALS AND METHODS: Here, some coumarin members, including umbelliprenin, 4-farnesyloxycoumarin, gummosin, samarcandin, farnesifrol A, B, C, and auraptan, have been assessed as QS inhibitors in silico and in vitro. ...
MATERIALS AND METHODS: Here, some coumarin members, including umbelliprenin, 4-farnesyloxycoumarin, gummosin, samarcandin, farnesifro …
Modulation of Multidrug Resistance Protein 2 Efflux in the Cisplatin Resistance Human Ovarian Carcinoma Cells A2780/RCIS by Sesquiterpene Coumarins.
Kasaian J, Mosaffa F, Behravan J, Masullo M, Piacente S, Iranshahi M. Kasaian J, et al. Phytother Res. 2016 Jan;30(1):84-9. doi: 10.1002/ptr.5504. Epub 2015 Oct 27. Phytother Res. 2016. PMID: 26503061
Among the tested compounds, mogoltacin, mogoltadone, farnesiferol A, farnesiferol B, farnesiferol C, lehmferin, conferdione, and samarcandin showed significant MDR reversing effects. The combination of nontoxic concentrations of SCs (20 muM) with cisplatin enhanced cisplat …
Among the tested compounds, mogoltacin, mogoltadone, farnesiferol A, farnesiferol B, farnesiferol C, lehmferin, conferdione, and samarcan …
Identification of sesquiterpene coumarins of oleo-gum resin of Ferula assa-foetida L. from the Yasuj region.
Asghari J, Atabaki V, Baher E, Mazaheritehrani M. Asghari J, et al. Nat Prod Res. 2016;30(3):350-3. doi: 10.1080/14786419.2015.1050669. Epub 2015 Jul 2. Nat Prod Res. 2016. PMID: 26134757
Chemical investigation of the oleo-gum resin of Ferula assa-foetida L. from Yasuj region led to the identification of five sesquiterpene coumarins namely, conferone (1), badrakemin (2), feslol (3), isosamarcandin (4) and samarcandin (5). The compounds were characterised by …
Chemical investigation of the oleo-gum resin of Ferula assa-foetida L. from Yasuj region led to the identification of five sesquiterpene cou …
Sesquiterpene coumarins from the roots of Ferula assa-foetida.
Abd El-Razek MH, Ohta S, Ahmed AA, Hirata T. Abd El-Razek MH, et al. Phytochemistry. 2001 Dec;58(8):1289-95. doi: 10.1016/s0031-9422(01)00324-7. Phytochemistry. 2001. PMID: 11738424
From the chloroform extract of the roots of Ferula assa-foetida, two sesquiterpene coumarins designated assafoetidnol A and assafoetidnol B were isolated, in addition to six known compounds, gummosin, polyanthin, badrakemin, neveskone, samarcandin and galbanic acid. The st …
From the chloroform extract of the roots of Ferula assa-foetida, two sesquiterpene coumarins designated assafoetidnol A and assafoetidnol B …
Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula assa-foetida against HSV-1.
Ghannadi A, Fattahian K, Shokoohinia Y, Behbahani M, Shahnoush A. Ghannadi A, et al. Iran J Pharm Res. 2014 Spring;13(2):523-30. Iran J Pharm Res. 2014. PMID: 25237347 Free PMC article.
Three sesquiterpene coumarins badrakemin acetate (1), kellerin (2) and samarcandin diastereomer (3) were isolated from the gum resin of Ferula assa-foetida, a herbal medicine with antimicrobial, antiprotozoal and antiviral effects. ...
Three sesquiterpene coumarins badrakemin acetate (1), kellerin (2) and samarcandin diastereomer (3) were isolated from the gum resin …