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PG110, A Humanized Anti-NGF Antibody, Reverses Established Pain Hypersensitivity in Persistent Inflammatory Pain, but not Peripheral Neuropathic Pain, Rat Models.
Djouhri L. Djouhri L. Pain Med. 2016 Nov;17(11):2082-2094. doi: 10.1093/pm/pnw007. Epub 2016 Feb 25. Pain Med. 2016. PMID: 26917622
RESULTS: Compared to vehicle treated group, PG110 dose dependently attenuated established heat and mechanical hypersensitivity induced by CFA, but not that induced by SNA. The anti-allodynic and anti-hyperalgesic effects of PG110 in the CFA model were similar to tho …
RESULTS: Compared to vehicle treated group, PG110 dose dependently attenuated established heat and mechanical hypersensitivity induce …
Crystal structure of lipoprotein GNA1946 from Neisseria meningitidis.
Yang X, Wu Z, Wang X, Yang C, Xu H, Shen Y. Yang X, et al. J Struct Biol. 2009 Dec;168(3):437-43. doi: 10.1016/j.jsb.2009.09.001. Epub 2009 Sep 3. J Struct Biol. 2009. PMID: 19733245
A comparison of GNA1946 with two other outer membrane lipoproteins, the L-methionine-binding Tp32 from Treponema pallidum and the dipeptide GlyMet-binding protein Pg110 from Staphylococcus aureus, revealed that although these three proteins share low sequence similarities, …
A comparison of GNA1946 with two other outer membrane lipoproteins, the L-methionine-binding Tp32 from Treponema pallidum and the dipeptide …
Targeting nerve growth factor (NGF) for pain management: what does the future hold for NGF antagonists?
Bannwarth B, Kostine M. Bannwarth B, et al. Drugs. 2014 Apr;74(6):619-26. doi: 10.1007/s40265-014-0208-6. Drugs. 2014. PMID: 24691709
In this respect, tanezumab is at an advanced stage of clinical development while fulranumab, fasinumab and ABT-110, previously known as PG110, are in early phases of clinical development. This Current Opinion article aims at describing the rationale for targeting NGF for p …
In this respect, tanezumab is at an advanced stage of clinical development while fulranumab, fasinumab and ABT-110, previously known as P …
11 results