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Did you mean nodulin (563 results)?
Semisynthesis and antibacterial activities of nidulin derivatives.
Isaka M, Yangchum A, Supothina S, Veeranondha S, Komwijit S, Phongpaichit S. Isaka M, et al. J Antibiot (Tokyo). 2019 Mar;72(3):181-184. doi: 10.1038/s41429-018-0133-0. Epub 2018 Dec 17. J Antibiot (Tokyo). 2019. PMID: 30555155
Derivatives of the fungal depsidone, nidulin, have been synthesized in order to evaluate the potential of the chemical skeleton as antibacterial agents. ...Many of the semisynthetic derivatives showed more potent antibacterial activities than nidulin, In particular, …
Derivatives of the fungal depsidone, nidulin, have been synthesized in order to evaluate the potential of the chemical skeleton as an …
(E)-2,4,7-Trichloro-3-hydr-oxy-8-meth-oxy-1,9-dimethyl-6-(1-methyl-1-propen-yl)-11H-dibenzo[b,e][1,4]dioxepin-11-one monohydrate (nidulin monohydrate).
Aree T, Surerum S, Ngamrojanavanich N, Kittakoop P. Aree T, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Sep 16;65(Pt 10):o2470-1. doi: 10.1107/S1600536809036277. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21577923 Free PMC article.
In the title compound, C(20)H(17)Cl(3)O(5).H(2)O, the nidulin mol-ecule consists of three rings, the folded central dioxepin-11-one ring being fused on both sides to phenyl rings. ...
In the title compound, C(20)H(17)Cl(3)O(5).H(2)O, the nidulin mol-ecule consists of three rings, the folded central dioxepin-11-one r …
The biosynthesis of nidulin and trisdechloronornidulin.
Sierankiewicz J, Gatenbeck S. Sierankiewicz J, et al. Acta Chem Scand. 1973;27(8):2710-6. doi: 10.3891/acta.chem.scand.27-2710. Acta Chem Scand. 1973. PMID: 4591514 No abstract available.
Expanding antibiotic chemical space around the nidulin pharmacophore.
Morshed MT, Vuong D, Crombie A, Lacey AE, Karuso P, Lacey E, Piggott AM. Morshed MT, et al. Org Biomol Chem. 2018 Apr 25;16(16):3038-3051. doi: 10.1039/c8ob00545a. Org Biomol Chem. 2018. PMID: 29634062
In this study, we have revisited the trichloro-substituted depsidone, nidulin, as a selective and unexploited antibiotic lead produced by the fungus Aspergillus unguis. ...In total, 12 new and 11 previously reported nidulin analogues were isolated, characterised and …
In this study, we have revisited the trichloro-substituted depsidone, nidulin, as a selective and unexploited antibiotic lead produce …
Fungal Depsidones Stimulate AKT-Dependent Glucose Uptake in 3T3-L1 Adipocytes.
Chantarasakha K, Yangchum A, Isaka M, Tepaamorndech S. Chantarasakha K, et al. J Nat Prod. 2024 Apr 10. doi: 10.1021/acs.jnatprod.3c01134. Online ahead of print. J Nat Prod. 2024. PMID: 38597733
Compared to the others, nidulin exhibited an upward trend in glucose uptake. The effect of nidulin was found to be dose- and time-dependent. Nidulin also enhanced insulin- and metformin-stimulated glucose uptake. ...
Compared to the others, nidulin exhibited an upward trend in glucose uptake. The effect of nidulin was found to be dose- and t …
Secondary Metabolites Diversity of Aspergillus unguis and Their Bioactivities: A Potential Target to Be Explored.
Domingos LTS, Martins RDS, Lima LM, Ghizelini AM, Ferreira-Pereira A, Cotinguiba F. Domingos LTS, et al. Biomolecules. 2022 Dec 6;12(12):1820. doi: 10.3390/biom12121820. Biomolecules. 2022. PMID: 36551248 Free PMC article. Review.
The first chemical study reported in the literature dates from 1970, with depsidones nidulin (1), nornidulin (2), and unguinol (3) being the first isolated compounds. ...
The first chemical study reported in the literature dates from 1970, with depsidones nidulin (1), nornidulin (2), and unguinol (3) be …
Antimicrobial Activity of Depsidones and Macrocyclic Peptides Isolated from Marine Sponge-Derived Fungus Aspergillus nidulans M256.
Thi Hoang Anh N, Mai Anh N, Thi Thu Huyen V, Thi Dao P, Thi Mai Huong D, Van Cuong P, Thanh Xuan D, Huu Tai B, Thi Hong Minh L, Van Kiem P. Thi Hoang Anh N, et al. Chem Biodivers. 2023 Dec;20(12):e202301660. doi: 10.1002/cbdv.202301660. Epub 2023 Nov 22. Chem Biodivers. 2023. PMID: 37957128
Of these, chlorinated depsidones (1-3, and 5) displayed potential antimicrobial activity. Nidulin (2) possessed good activity against tested strains except for S. enterica with MIC values in range of 2-16 mug/mL. ...
Of these, chlorinated depsidones (1-3, and 5) displayed potential antimicrobial activity. Nidulin (2) possessed good activity against …
Evaluation of Benzguinols as Next-Generation Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infections.
Nguyen HT, Morshed MT, Vuong D, Crombie A, Lacey E, Garg S, Pi H, Woolford L, Venter H, Page SW, Piggott AM, Trott DJ, Ogunniyi AD. Nguyen HT, et al. Antibiotics (Basel). 2021 Jun 16;10(6):727. doi: 10.3390/antibiotics10060727. Antibiotics (Basel). 2021. PMID: 34208698 Free PMC article.
Our recent focus on the "lost antibiotic" unguinol and related nidulin-family fungal natural products identified two semisynthetic derivatives, benzguinols A and B, with unexpected in vitro activity against Staphylococcus aureus isolates either susceptible or resistant to …
Our recent focus on the "lost antibiotic" unguinol and related nidulin-family fungal natural products identified two semisynthetic de …
14 results