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1959 1
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1969 1
1974 1
1975 1
1982 1
1983 1
1999 1
2000 1
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18 results

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Page 1
Oxycodone.
[No authors listed] [No authors listed] 2024 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2024 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000304 Free Books & Documents. Review.
Potential of the strain Raoultella sp. KDF8 for removal of analgesics.
Palyzová A, Zahradník J, Marešová H, Sokolová L, Kyslíková E, Grulich M, Štěpánek V, Řezanka T, Kyslík P. Palyzová A, et al. Folia Microbiol (Praha). 2018 May;63(3):273-282. doi: 10.1007/s12223-017-0563-2. Epub 2017 Nov 11. Folia Microbiol (Praha). 2018. PMID: 29127620
HPLC analysis identified 4'-hydroxydiclofenac as a major metabolite of diclofenac transformation and 14-hydroxycodeinone as codeine transformation product. The analgesics ibuprofen and ketoprofen were also removed, albeit to a lower extent of 3.2 and 2.0 mg/g(CDW) per h, r …
HPLC analysis identified 4'-hydroxydiclofenac as a major metabolite of diclofenac transformation and 14-hydroxycodeinone as codeine t …
Exploring the Function of (+)-Naltrexone Precursors: Their Activity as TLR4 Antagonists and Potential in Treating Morphine Addiction.
Gao J, Lin C, Zhang C, Zhang X, Wang Y, Xu H, Zhang T, Li H, Wang H, Wang X. Gao J, et al. J Med Chem. 2024 Feb 22;67(4):3127-3143. doi: 10.1021/acs.jmedchem.3c02316. Epub 2024 Feb 2. J Med Chem. 2024. PMID: 38306598
Herein, we developed a concise 10-step synthesis for (+)-naltrexone and explored its precursors, (+)-14-hydroxycodeinone (1) and (+)-14-hydroxymorphinone (3). These precursors exhibited TLR4 antagonistic activities 100 times stronger than (+)-naltrexone, particularly inhib …
Herein, we developed a concise 10-step synthesis for (+)-naltrexone and explored its precursors, (+)-14-hydroxycodeinone (1) and (+)- …
Transformations of codeine to important semisynthetic opiate derivatives by Pseudomonas putida m10.
Lister DL, Kanungo G, Rathbone DA, Bruce NC. Lister DL, et al. FEMS Microbiol Lett. 1999 Dec 1;181(1):137-44. doi: 10.1111/j.1574-6968.1999.tb08836.x. FEMS Microbiol Lett. 1999. PMID: 10564799
Incubations with the same organism and codeinone gave rise to 14beta-hydroxycodeinone and 14beta-hydroxycodeine. Cell-free extracts and membrane fractions of P. putida M10 were shown to catalyse the 14beta-hydroxylation of codeinone. In addition, the potent analgesic oxyco …
Incubations with the same organism and codeinone gave rise to 14beta-hydroxycodeinone and 14beta-hydroxycodeine. Cell-free extracts a …
Synthesis and Characterization of a Novel Diels - Alder Adduct of Codeine.
Cunningham CW, Hom K, Acharya C, Wilks A, Mackerell AD Jr, Coop A. Cunningham CW, et al. Helv Chim Acta. 2010 Feb;93(2):220-226. doi: 10.1002/hlca.200900234. Helv Chim Acta. 2010. PMID: 23378668 Free PMC article.
The Diels - Alder reaction was applied to 4,5-epoxymorphinan opioids to generate a novel aromatic cycloadduct at C(7) - C(8): Thermolytic cleavage of sultine 8 produced the reactive diene o-quinodimethane 7 which condensed favorably with codeine (11), but not with codeinone (9) o …
The Diels - Alder reaction was applied to 4,5-epoxymorphinan opioids to generate a novel aromatic cycloadduct at C(7) - C(8): Thermolytic cl …
Modified in vivo comet assay detects the genotoxic potential of 14-hydroxycodeinone, an alpha,beta-unsaturated ketone in oxycodone.
Pant K, Roden N, Zhang C, Bruce S, Wood C, Pendino K. Pant K, et al. Environ Mol Mutagen. 2015 Dec;56(9):777-87. doi: 10.1002/em.21957. Epub 2015 May 13. Environ Mol Mutagen. 2015. PMID: 25913631
14-Hydroxycodeinone (14-HC) is an alpha,beta-unsaturated ketone impurity found in oxycodone drug substance and has a structural alert for genotoxicity. 14-HC was tested in a combined Modified and Standard Comet Assay to determine if the slight decrease in % Tail DNA noted …
14-Hydroxycodeinone (14-HC) is an alpha,beta-unsaturated ketone impurity found in oxycodone drug substance and has a structural alert …
14-hydroxycodeinone. An improved synthesis.
Hauser FM, Chen TK, Carroll FI. Hauser FM, et al. J Med Chem. 1974 Oct;17(10):1117. doi: 10.1021/jm00256a019. J Med Chem. 1974. PMID: 4425445 No abstract available.
Enzymatic transformation of morphine by hydroxysteroid dehydrogenase from Pseudomonas testosteroni.
Liras P, Kasparian SS, Umbreit WW. Liras P, et al. Appl Microbiol. 1975 Oct;30(4):650-6. doi: 10.1128/am.30.4.650-656.1975. Appl Microbiol. 1975. PMID: 172013 Free PMC article.
Morphine was converted in relatively low yield into 14-hydroxymorphinone probably via morphinone as an intermediate. Codeine was converted to codeinone and 14-hydroxycodeinone. Only the conversions at the 6-position were carred out by the hydroxysteroid dehydrogenase. ...
Morphine was converted in relatively low yield into 14-hydroxymorphinone probably via morphinone as an intermediate. Codeine was converted t …
18 results