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1981 1
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Page 1
[Symptomatic effect of epomediol in patients with cholestasis of pregnancy].
González M, Iglesias J, Tiribelli C, Ribalta J, Reyes H, Hernández I, Bianchi M, Andrighetti F, Molina C. González M, et al. Rev Med Chil. 1992 May;120(5):545-51. Rev Med Chil. 1992. PMID: 1343068 Clinical Trial. Spanish.
Assuming that the pathogenesis of intrahepatic cholestasis of pregnancy (ICP) is related with increased estrogen levels, we studied the effects of epomediol in this disease. Patients hospitalized due to ICP received epomediol 900 mg/day (n = 7), or 1,200 mg/day (n = …
Assuming that the pathogenesis of intrahepatic cholestasis of pregnancy (ICP) is related with increased estrogen levels, we studied the effe …
Effect of epomediol on ethinyloestradiol-induced changes in bile acid and cholesterol metabolism in rats.
Cuevas MJ, Mauriz JL, Almar M, Collado PS, González-Gallego J. Cuevas MJ, et al. Clin Exp Pharmacol Physiol. 2001 Aug;28(8):637-42. doi: 10.1046/j.1440-1681.2001.03496.x. Clin Exp Pharmacol Physiol. 2001. PMID: 11473529
Levels of cholesterol 7alpha-hydroxylase mRNA were elevated (+41%) by epomediol, but were not significantly modified by ethinyloestradiol or ethinyloestradiol plus epomediol. 4. ...Changes in bile acid metabolism contribute to the effects of epomediol in rats …
Levels of cholesterol 7alpha-hydroxylase mRNA were elevated (+41%) by epomediol, but were not significantly modified by ethinyloestra …
Effect of epomediol on taurocholate uptake in hepatocytes isolated from normal rats or rats with ethinyloestradiol-induced cholestasis.
Barone M, Azzarone A, Angelini A, Zamparella M, Dell'Aquila P, Francavilla A. Barone M, et al. Pharmacol Toxicol. 1993 Apr-May;72(4-5):296-9. doi: 10.1111/j.1600-0773.1993.tb01653.x. Pharmacol Toxicol. 1993. PMID: 8372050
To this purpose, primary cultures were prepared with hepatocytes obtained from normal rats (Group I), and rats receiving a 4-day treatment with either epomediol (100 mg/kg) (Group II), or ethinyloestradiol (5 mg/kg) (Group III), or ethinyloestradiol plus epomediol ( …
To this purpose, primary cultures were prepared with hepatocytes obtained from normal rats (Group I), and rats receiving a 4-day treatment w …
Effects of epomediol on ethinyloestradiol-induced changes in glutathione homeostasis in the rat.
Cuevas MJ, Almar M, González-Gallego J. Cuevas MJ, et al. Pharmacol Toxicol. 2002 Mar;90(3):121-6. doi: 10.1034/j.1600-0773.2002.900302.x. Pharmacol Toxicol. 2002. PMID: 12071332
Epomediol is a synthetic terpenoid compound that has been reported to reduce ethinyloestradiol-induced cholestasis. ...Combined treatment with epomediol plus ethinyloestradiol normalised renal GSH and both biliary and liver cysteine were significantly increased. ...
Epomediol is a synthetic terpenoid compound that has been reported to reduce ethinyloestradiol-induced cholestasis. ...Combined treat …
Reversal of ethinylestradiol-induced cholestasis by epomediol in rat. The role of liver plasma-membrane fluidity.
Miccio M, Orzes N, Lunazzi GC, Gazzin B, Corsi R, Tiribelli C. Miccio M, et al. Biochem Pharmacol. 1989 Oct 15;38(20):3559-63. doi: 10.1016/0006-2952(89)90128-7. Biochem Pharmacol. 1989. PMID: 2554925
Epomediol (EPO) is a synthetic terpenoid compound shown to be active in increasing bile flow and some enzymatic activities of liver plasma membranes in the rat. ...
Epomediol (EPO) is a synthetic terpenoid compound shown to be active in increasing bile flow and some enzymatic activities of liver p …
Effect of the terpenic compound epomediol on biliary secretion and bile composition in the rat.
Zanninelli G, Tavanti A, Munoz ME, Ricci GL. Zanninelli G, et al. J Hepatol. 1992 Jan;14(1):64-70. doi: 10.1016/0168-8278(92)90132-9. J Hepatol. 1992. PMID: 1737917
The extent of epomediol action also changes according to the different rates of bile acid secretion. ...Excretion into bile of the epomediol glucuronide was not hampered by high Na+ taurocholate output. ...
The extent of epomediol action also changes according to the different rates of bile acid secretion. ...Excretion into bile of the …
Intrahepatic cholestasis of pregnancy: an estrogen-related disease.
Reyes H, Simon FR. Reyes H, et al. Semin Liver Dis. 1993 Aug;13(3):289-301. doi: 10.1055/s-2007-1007357. Semin Liver Dis. 1993. PMID: 8235718 Review.
New drugs have been shown capable of providing promising therapeutic effects either on pruritus, the main distressing symptoms of cholestasis (such as epomediol, silymarin) or both on pruritus and some biochemical abnormalities (such as UDCA). ...
New drugs have been shown capable of providing promising therapeutic effects either on pruritus, the main distressing symptoms of cholestasi …
Enhancement of bile acid pool size, synthesis and secretion by epomediol in the rat.
Mauriz JL, Cuevas MJ, El-Mir MY, Almar M, Collado PS, Gonzalez-Gallego J. Mauriz JL, et al. Dig Dis Sci. 2000 Jul;45(7):1431-8. doi: 10.1023/a:1005528725319. Dig Dis Sci. 2000. PMID: 10961725
Epomediol is a terpenoid compound that has been reported to reverse 17alpha-ethinylestradiol-induced cholestasis and to have a choleretic effect related to the biliary secretion of epomediol glucuronide. ...It is concluded that epomediol treatment expands the …
Epomediol is a terpenoid compound that has been reported to reverse 17alpha-ethinylestradiol-induced cholestasis and to have a choler …
Effect of ethinylestradiol and epomediol on bile flow and biliary lipid composition in rat.
Rodriguez JV, Torres AM, Lunazzi G, Tiribelli C. Rodriguez JV, et al. Biochem Pharmacol. 1992 Mar 17;43(6):1289-93. doi: 10.1016/0006-2952(92)90505-d. Biochem Pharmacol. 1992. PMID: 1562282
Epomediol (1,3,3-trimethyl-2-oxabicyclo(2.2.2.)octan-6,7-endo,endo-diol) (EPO) is a terpenoid compound shown to reverse 17 alpha-ethinylestradiol (EE)-induced cholestasis in rat. ...
Epomediol (1,3,3-trimethyl-2-oxabicyclo(2.2.2.)octan-6,7-endo,endo-diol) (EPO) is a terpenoid compound shown to reverse 17 alpha-ethi …
32 results