Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 4
1966 2
1967 1
1968 1
1969 7
1970 8
1971 1
1976 3
1977 1
1978 6
1979 9
1980 9
1981 7
1982 9
1983 7
1984 18
1985 9
1986 19
1987 24
1988 15
1989 9
1990 8
1991 15
1992 8
1993 10
1994 5
1995 7
1996 7
1997 7
1998 12
1999 2
2000 9
2001 3
2002 12
2003 10
2004 8
2005 10
2006 8
2007 7
2008 10
2009 4
2010 3
2011 9
2012 6
2013 5
2014 5
2015 4
2016 6
2017 2
2018 1
2019 2
2020 2
2021 3
2022 4
2023 9
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

383 results

Results by year

Filters applied: . Clear all
Page 1
Structural Basis for DNA Gyrase Interaction with Coumermycin A1.
Vanden Broeck A, McEwen AG, Chebaro Y, Potier N, Lamour V. Vanden Broeck A, et al. J Med Chem. 2019 Apr 25;62(8):4225-4231. doi: 10.1021/acs.jmedchem.8b01928. Epub 2019 Apr 3. J Med Chem. 2019. PMID: 30920824
Coumermycin A1 is a natural aminocoumarin that inhibits bacterial DNA gyrase, a member of the GHKL proteins superfamily. We report here the first cocrystal structures of gyrase B bound to coumermycin A1, revealing that one coumermycin A1 …
Coumermycin A1 is a natural aminocoumarin that inhibits bacterial DNA gyrase, a member of the GHKL proteins superfamily. We re …
Coumermycin A1-Biopharmaceutical studies. II.
Newmark HL, Berger J, Carstensen JT. Newmark HL, et al. J Pharm Sci. 1970 Sep;59(9):1249-51. doi: 10.1002/jps.2600590906. J Pharm Sci. 1970. PMID: 5469784 No abstract available.
Coumermycin A1 inhibits growth and induces relaxation of supercoiled plasmids in Borrelia burgdorferi, the Lyme disease agent.
Samuels DS, Garon CF. Samuels DS, et al. Antimicrob Agents Chemother. 1993 Jan;37(1):46-50. doi: 10.1128/AAC.37.1.46. Antimicrob Agents Chemother. 1993. PMID: 8381639 Free PMC article.
Coumermycin A1 is an inhibitor of DNA gyrase, an enzyme that catalyzes supercoiling of DNA and is required for bacterial DNA replication. ...Coumermycin at 0.2 micrograms/ml inhibited the growth of B. burgdorferi B31 in BSK II medium. ...
Coumermycin A1 is an inhibitor of DNA gyrase, an enzyme that catalyzes supercoiling of DNA and is required for bacterial DNA r …
Coumarin-containing hybrids and their antibacterial activities.
Feng D, Zhang A, Yang Y, Yang P. Feng D, et al. Arch Pharm (Weinheim). 2020 Jun;353(6):e1900380. doi: 10.1002/ardp.201900380. Epub 2020 Apr 6. Arch Pharm (Weinheim). 2020. PMID: 32253782 Review.
The coumarin moiety, which is ubiquitous in nature, could bind to the B subunit of DNA gyrase in bacteria and inhibit DNA supercoiling by blocking the ATPase activity; hence, coumarin derivatives possess potential antibacterial activity. Several coumarin-containing hybrids such a …
The coumarin moiety, which is ubiquitous in nature, could bind to the B subunit of DNA gyrase in bacteria and inhibit DNA supercoiling by bl …
Coumermycin A1: A preferential inhibitor of replicative DNA synthesis in Escherichia coli. I. In vivo characterization.
Ryan MJ. Ryan MJ. Biochemistry. 1976 Aug 24;15(17):3769-77. doi: 10.1021/bi00662a020. Biochemistry. 1976. PMID: 782522
Coumermycin A1-resistant E. coli were isolated and the mutation was mapped near dnaA. ...Results showed that the effect of coumermycin A1 cannot be explained by the degradation of DNA under bacteriocidal growth conditions....
Coumermycin A1-resistant E. coli were isolated and the mutation was mapped near dnaA. ...Results showed that the effect of …
The gut microbiota metabolite butyrate mitigates MPTP/MPP+ -induced Parkinson's disease by inhibiting the JAK2/STAT3 signaling pathway.
Ji LL, Huang TT, Mao LL, Xu YF, Chen WY, Wang WW, Wang LH. Ji LL, et al. Kaohsiung J Med Sci. 2023 Oct;39(10):1002-1010. doi: 10.1002/kjm2.12745. Kaohsiung J Med Sci. 2023. PMID: 37807941 Free article.
Furthermore, BU inhibited MPTP/MPP(+) -induced hyperactivation of the JAK2/STAT3 signaling in mice and PC12 cells. Besides, a JAK2 agonist, Coumermycin A1 (C-A1), substantially reversed BU-mediated inhibition on JAK2/STAT3 phosphorylation in MPP(+) -challenged PC12 …
Furthermore, BU inhibited MPTP/MPP(+) -induced hyperactivation of the JAK2/STAT3 signaling in mice and PC12 cells. Besides, a JAK2 agonist, …
Inducible HEK293 AAV packaging cell lines expressing Rep proteins.
Jalšić L, Lytvyn V, Elahi SM, Hrapovic S, Nassoury N, Chahal PS, Gaillet B, Gilbert R. Jalšić L, et al. Mol Ther Methods Clin Dev. 2023 Jul 15;30:259-275. doi: 10.1016/j.omtm.2023.07.002. eCollection 2023 Sep 14. Mol Ther Methods Clin Dev. 2023. PMID: 37560197 Free PMC article.
Using suspension and serum-free media adapted HEK293SF carrying a gene expression regulation system induced by addition of cumate and coumermycin, we were able to create REP-expressing AAV packaging cells. ...
Using suspension and serum-free media adapted HEK293SF carrying a gene expression regulation system induced by addition of cumate and cou …
Treatment of Staphylococcus aureus endocarditis in rats with coumermycin A1 and ciprofloxacin, alone or in combination.
Perronne CM, Malinverni R, Glauser MP. Perronne CM, et al. Antimicrob Agents Chemother. 1987 Apr;31(4):539-43. doi: 10.1128/AAC.31.4.539. Antimicrob Agents Chemother. 1987. PMID: 3606060 Free PMC article.
The efficacy of a 5-day treatment with coumermycin A1 (hereafter referred to as coumermycin) (at three dosage regimens), with ciprofloxacin, or with coumermycin plus ciprofloxacin was tested in experimental aortic valve endocarditis induced in rats by …
The efficacy of a 5-day treatment with coumermycin A1 (hereafter referred to as coumermycin) (at three dosage regimens) …
383 results