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Conjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic properties.
Al-Mudaris ZA, Majid AS, Ji D, Al-Mudarris BA, Chen SH, Liang PH, Osman H, Jamal Din SK, Abdul Majid AM. Al-Mudaris ZA, et al. PLoS One. 2013 Nov 15;8(11):e80983. doi: 10.1371/journal.pone.0080983. eCollection 2013. PLoS One. 2013. PMID: 24260527 Free PMC article.
DNA binding study primarily by the equilibrium binding titration assay followed by the Viscosity study reveal the DNA binding through groove region with intrinsic binding constant 7.39 M/bp and 6.86 M/bp for 3BS and 2XP respectively. 2XP and 3BS showed strong DNA binding activity …
DNA binding study primarily by the equilibrium binding titration assay followed by the Viscosity study reveal the DNA binding through groove …