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Page 1
Investigating MARK4 inhibitory potential of Bacopaside II: Targeting Alzheimer's disease.
Anwar S, Mohammad T, Azhar MK, Fatima H, Alam A, Hasan GM, Islam A, Kaur P, Hassan MI. Anwar S, et al. Int J Biol Macromol. 2023 Aug 1;245:125364. doi: 10.1016/j.ijbiomac.2023.125364. Epub 2023 Jun 13. Int J Biol Macromol. 2023. PMID: 37315665
The plant extract is used as a memory enhancer and a brain tonic. Bacopaside II is a major component of Bacopa monnieri; thus, we studied its inhibitory effects and binding affinity towards the MARK4. Bacopaside II show a considerable binding affinity …
The plant extract is used as a memory enhancer and a brain tonic. Bacopaside II is a major component of Bacopa monnieri; thus, …
The Aquaporin 1 Inhibitor Bacopaside II Reduces Endothelial Cell Migration and Tubulogenesis and Induces Apoptosis.
Palethorpe HM, Tomita Y, Smith E, Pei JV, Townsend AR, Price TJ, Young JP, Yool AJ, Hardingham JE. Palethorpe HM, et al. Int J Mol Sci. 2018 Feb 26;19(3):653. doi: 10.3390/ijms19030653. Int J Mol Sci. 2018. PMID: 29495367 Free PMC article.
The effect of bacopaside II on viability, apoptosis, migration and tubulogenesis was assessed by a proliferation assay, annexin-V/propidium iodide flow cytometry, the scratch wound assay and endothelial tube-formation, respectively. ...Tube-formation was reduced wit …
The effect of bacopaside II on viability, apoptosis, migration and tubulogenesis was assessed by a proliferation assay, annexi …
Insights Into the Molecular Aspects of Neuroprotective Bacoside A and Bacopaside I.
Sekhar VC, Viswanathan G, Baby S. Sekhar VC, et al. Curr Neuropharmacol. 2019;17(5):438-446. doi: 10.2174/1570159X16666180419123022. Curr Neuropharmacol. 2019. PMID: 29676230 Free PMC article. Review.
Bacoside A, the vital neuroprotective constituent, is composed of four constituents viz., bacoside A3, bacopaside II, jujubogenin isomer of bacopasaponin C (bacopaside X) and bacopasaponin C. ...
Bacoside A, the vital neuroprotective constituent, is composed of four constituents viz., bacoside A3, bacopaside II, jujuboge …
The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis.
Smith E, Palethorpe HM, Tomita Y, Pei JV, Townsend AR, Price TJ, Young JP, Yool AJ, Hardingham JE. Smith E, et al. Cells. 2018 Jul 21;7(7):81. doi: 10.3390/cells7070081. Cells. 2018. PMID: 30037060 Free PMC article.
The aim of this study was to further elucidate the anti-tumour potential of bacopaside II in colon cancer cells. Expression of AQP1 in HT-29, SW480, SW620 and HCT116 was determined by quantitative PCR and western immunoblot. ...AQP1 expression was significantly high …
The aim of this study was to further elucidate the anti-tumour potential of bacopaside II in colon cancer cells. Expression of …
Combined pharmacological administration of AQP1 ion channel blocker AqB011 and water channel blocker Bacopaside II amplifies inhibition of colon cancer cell migration.
De Ieso ML, Pei JV, Nourmohammadi S, Smith E, Chow PH, Kourghi M, Hardingham JE, Yool AJ. De Ieso ML, et al. Sci Rep. 2019 Sep 2;9(1):12635. doi: 10.1038/s41598-019-49045-9. Sci Rep. 2019. PMID: 31477744 Free PMC article.
Migration rates were quantified using circular wound closure assays and live-cell tracking. AqB011 and bacopaside II, applied in combination, produced greater inhibitory effects on cell migration than did either agent alone. The high efficacy of AqB011 alone and in …
Migration rates were quantified using circular wound closure assays and live-cell tracking. AqB011 and bacopaside II, applied …
Differential Inhibition of Water and Ion Channel Activities of Mammalian Aquaporin-1 by Two Structurally Related Bacopaside Compounds Derived from the Medicinal Plant Bacopa monnieri.
Pei JV, Kourghi M, De Ieso ML, Campbell EM, Dorward HS, Hardingham JE, Yool AJ. Pei JV, et al. Mol Pharmacol. 2016 Oct;90(4):496-507. doi: 10.1124/mol.116.105882. Epub 2016 Jul 29. Mol Pharmacol. 2016. PMID: 27474162
Here we report two new modulators of AQP1 channels, bacopaside I and bacopaside II, isolated from the medicinal plant Bacopa monnieri Screening was conducted in the Xenopus oocyte expression system, using quantitative swelling and two-electrode voltage clamp techniq …
Here we report two new modulators of AQP1 channels, bacopaside I and bacopaside II, isolated from the medicinal plant Bacopa m …
'Bacoside B'--the need remains for establishing identity.
Deepak M, Amit A. Deepak M, et al. Fitoterapia. 2013 Jun;87:7-10. doi: 10.1016/j.fitote.2013.03.011. Epub 2013 Mar 16. Fitoterapia. 2013. PMID: 23506783 Review.
Subsequently 'bacoside A' was identified as a mixture of four saponins [bacoside A3 (1), bacopaside II (2), bacopasaponin C (3) and the jujobogenin isomer of the latter (4)] and was considered as part of major constituents of the herb along with bacopaside I (5). .. …
Subsequently 'bacoside A' was identified as a mixture of four saponins [bacoside A3 (1), bacopaside II (2), bacopasaponin C (3 …
40 results