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Ethnopharmacological Potentials of Warburgia ugandensis on Antimicrobial Activities.
Okello D, Kang Y. Okello D, et al. Chin J Integr Med. 2021 Aug;27(8):633-640. doi: 10.1007/s11655-019-3042-6. Epub 2019 Dec 17. Chin J Integr Med. 2021. PMID: 31848891 Review.
Extracts from W. ugandensis have strong antimicrobial activities against a broad spectrum of pathogens mainly because of the presence of abundant terpenoids, drimane, and coloratane type sesquditerpenoids amongst which are ugandensial, warburganal, mukaadial, and other sec …
Extracts from W. ugandensis have strong antimicrobial activities against a broad spectrum of pathogens mainly because of the presence of abu …
Plant Preparations and Compounds with Activities against Biofilms Formed by Candida spp.
Karpiński TM, Ożarowski M, Seremak-Mrozikiewicz A, Wolski H, Adamczak A. Karpiński TM, et al. J Fungi (Basel). 2021 May 5;7(5):360. doi: 10.3390/jof7050360. J Fungi (Basel). 2021. PMID: 34063007 Free PMC article. Review.
Activity in concentrations below 16 mg/L was observed with phenolic compounds (thymol, pterostilbene, and eugenol), sesquiterpene derivatives (warburganal, polygodial, and ivalin), chalconoid (lichochalcone A), steroidal saponin (dioscin), flavonoid (baicalein), alkaloids …
Activity in concentrations below 16 mg/L was observed with phenolic compounds (thymol, pterostilbene, and eugenol), sesquiterpene derivative …
Warburgia: a comprehensive review of the botany, traditional uses and phytochemistry.
Leonard CM, Viljoen AM. Leonard CM, et al. J Ethnopharmacol. 2015 May 13;165:260-85. doi: 10.1016/j.jep.2015.02.021. Epub 2015 Feb 17. J Ethnopharmacol. 2015. PMID: 25698247 Review.
Most of the biological activities are attributed to the drimane sesquiterpenoids, including polygodial, warburganal, muzigadial, mukaadial and ugandensial, flavonoids and miscellaneous compounds present in the various species. ...
Most of the biological activities are attributed to the drimane sesquiterpenoids, including polygodial, warburganal, muzigadial, muka …
Physiological activity of warburganal and its reactivity with sulfhydryl groups.
Taniguchi M, Adachi T, Haraguchi H, Oi S, Kubo I. Taniguchi M, et al. J Biochem. 1983 Jul;94(1):149-54. doi: 10.1093/oxfordjournals.jbchem.a134323. J Biochem. 1983. PMID: 6352692 Free article.
L-Cysteine prevented this enzyme inhibition by warburganal but could not restore the enzyme activity lost already due to warburganal. Warburganal lost its characteristic ultraviolet absorption spectrum in the presence of L-cysteine. ...
L-Cysteine prevented this enzyme inhibition by warburganal but could not restore the enzyme activity lost already due to warburgan …
Biofilm inhibiting properties of compounds from the leaves of Warburgia ugandensis Sprague subsp ugandensis against Candida and staphylococcal biofilms.
Kipanga PN, Liu M, Panda SK, Mai AH, Veryser C, Van Puyvelde L, De Borggraeve WM, Van Dijck P, Matasyoh J, Luyten W. Kipanga PN, et al. J Ethnopharmacol. 2020 Feb 10;248:112352. doi: 10.1016/j.jep.2019.112352. Epub 2019 Oct 30. J Ethnopharmacol. 2020. PMID: 31676401
For both warburganal and polygodial, the biofilm inhibitory concentration that inhibits 50% of C. albicans developing biofilms (BIC(50)) was 4.5 1 and 10.8 5 mug/mL respectively. Against S. aureus developing biofilms, this value was 37.9 8 mug/mL and 25 mug/mL with warb …
For both warburganal and polygodial, the biofilm inhibitory concentration that inhibits 50% of C. albicans developing biofilms (BIC(5 …
Structure-Pungency Relationships and TRP Channel Activation of Drimane Sesquiterpenes in Tasmanian Pepper (Tasmannia lanceolata).
Mathie K, Lainer J, Spreng S, Dawid C, Andersson DA, Bevan S, Hofmann T. Mathie K, et al. J Agric Food Chem. 2017 Jul 19;65(28):5700-5712. doi: 10.1021/acs.jafc.7b02356. Epub 2017 Jul 7. J Agric Food Chem. 2017. PMID: 28657737 Free article.
Sensory-guided fractionation of extracts of Tasmanian pepper berries revealed 20 drimane sesquiterpens, among which polygodial, warburganal, and 1beta-acetoxy-9-deoxy-isomuzigadial exhibited the lowest pungency threshold concentrations on the tongue surface (0.6-2.8 nmol/c …
Sensory-guided fractionation of extracts of Tasmanian pepper berries revealed 20 drimane sesquiterpens, among which polygodial, warburgan …
Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial.
Liu M, Kipanga P, Mai AH, Dhondt I, Braeckman BP, De Borggraeve W, Luyten W. Liu M, et al. Int J Parasitol. 2018 Sep;48(11):833-844. doi: 10.1016/j.ijpara.2017.11.009. Epub 2018 Jul 18. Int J Parasitol. 2018. PMID: 30031002
Three active compounds were purified and identified by nuclear magnetic resonance and high resolution MS: warburganal (IC(50): 28.2 8.6 muM), polygodial (IC(50): 13.1 5.3 muM) and alpha-linolenic acid (ALA, IC(50): 70.1 17.5 muM). A checkerboard assay for warburganal …
Three active compounds were purified and identified by nuclear magnetic resonance and high resolution MS: warburganal (IC(50): 28.2 8 …
Antiparasitic Potential of Chromatographic Fractions of Nephrolepis biserrata and Liquid Chromatography-Quadrupole Time-of-Flight-Mass Spectrometry Analysis.
Shah MD, Tani K, Yong YS, Ching FF, Shaleh SRM, Vairappan CS, Venmathi Maran BA. Shah MD, et al. Molecules. 2021 Jan 19;26(2):499. doi: 10.3390/molecules26020499. Molecules. 2021. PMID: 33477743 Free PMC article.
LC-QTOF-MS analysis indicated the presence of secondary metabolites including phytosphingosine (6), pyrethrosin (1), haplophytine (9), ivalin (2), warburganal (3), isodomedin (4) and pheophorbide a (16), representing sphingoid, alkaloid, terpenoid, phenolic and flavonoid g …
LC-QTOF-MS analysis indicated the presence of secondary metabolites including phytosphingosine (6), pyrethrosin (1), haplophytine (9), ivali …
Synthesis of antifeedants for insects: novel behaviour-modifying chemicals from plants.
Ley SV. Ley SV. Ciba Found Symp. 1990;154:80-7; discussion 87-98. doi: 10.1002/9780470514009.ch7. Ciba Found Symp. 1990. PMID: 2086043 Review.
Our synthetic studies on the sesquiterpenoid antifeedants, polygodial and warburganal, and on the diterpenoid clerodane, ajurgarin I, have shown the promise of this approach. ...
Our synthetic studies on the sesquiterpenoid antifeedants, polygodial and warburganal, and on the diterpenoid clerodane, ajurgarin I, …
21 results