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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1990 8
1991 2
1992 4
1993 4
1994 5
1995 8
1996 9
1997 10
1998 18
1999 14
2000 11
2001 7
2002 4
2003 4
2004 6
2005 4
2006 5
2007 3
2008 4
2009 3
2010 4
2011 6
2012 1
2013 5
2014 3
2015 4
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2018 3
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2022 2
2024 0

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166 results

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Page 1
Aromatase inhibitors: Role in postmenopausal breast cancer.
Kharb R, Haider K, Neha K, Yar MS. Kharb R, et al. Arch Pharm (Weinheim). 2020 Aug;353(8):e2000081. doi: 10.1002/ardp.202000081. Epub 2020 May 25. Arch Pharm (Weinheim). 2020. PMID: 32449548 Review.
There are many aromatase inhibitors available in clinical practice like exemestane, formestane, anastrozole, letrozole, fadrozole, vorozole, and so forth, but the major challenge in anti-breast cancer therapy is the toxicity associated with aromatase inhibitors, especially …
There are many aromatase inhibitors available in clinical practice like exemestane, formestane, anastrozole, letrozole, fadrozole, vorozo …
Vorozole.
Wiseman LR, Spencer CM. Wiseman LR, et al. Drugs Aging. 1997 Sep;11(3):245-50; discussion 251-2. doi: 10.2165/00002512-199711030-00007. Drugs Aging. 1997. PMID: 9303282 Review.
Vorozole improved patients' quality of life to a greater extent than aminoglutethimide. ...The most common adverse events with vorozole are hot flushes, and nausea, which are generally mild in severity....
Vorozole improved patients' quality of life to a greater extent than aminoglutethimide. ...The most common adverse events with vor …
(S)-6-[(4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-[11C]methyl-1H-benzotriazole.
Leung K. Leung K. 2009 May 8 [updated 2009 Jul 1]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. 2009 May 8 [updated 2009 Jul 1]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641399 Free Books & Documents. Review.
(S)-6-[(4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole (vorozole) is an aromatase inhibitor with a inhibition constant (K(i)) value of 1 nM. Lidstrom et al. (7) prepared [(11)C]vorozole by N-methylation of (S)-6-[(4-chlorophenyl)(1H-1,2,4-tr …
(S)-6-[(4-Chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H-benzotriazole (vorozole) is an aromatase inhibitor with a inhibitio …
Pre-clinical and clinical review of vorozole, a new third generation aromatase inhibitor.
Goss PE. Goss PE. Breast Cancer Res Treat. 1998;49 Suppl 1:S59-65; discussion S73-7. doi: 10.1023/a:1006052923468. Breast Cancer Res Treat. 1998. PMID: 9797019 Review.
Vorozole (Rivizor), is a triazole derivative and one of the new, third generation aromatase inhibitors. ...Against MA, response rates were comparable (10.5% vorozole; 7.6% MA) however, a trend towards improvement in median duration of response for vorozole (1 …
Vorozole (Rivizor), is a triazole derivative and one of the new, third generation aromatase inhibitors. ...Against MA, response rates …
[Aromatase inhibitors].
Feutrie ML, Bonneterre J. Feutrie ML, et al. Bull Cancer. 1999 Oct;86(10):821-7. Bull Cancer. 1999. PMID: 10572233 Free article. Review. French.
The clinical development has been stopped due to a lack of specificity. Letrozole, vorozole, exemestane and anastrozole are more powerful and more specific. Letrozole and vorozole are at least as efficient and better tolerated than aminoglutethimide. ...
The clinical development has been stopped due to a lack of specificity. Letrozole, vorozole, exemestane and anastrozole are more powe …
Vorozole, a specific non-steroidal aromatase inhibitor.
Wouters W, Snoeck E, De Coster R. Wouters W, et al. Breast Cancer Res Treat. 1994;30(1):89-94. doi: 10.1007/BF00682743. Breast Cancer Res Treat. 1994. PMID: 7726994 Review.
Vorozole, the (+)-(S)-isomer of a new triazole compound, is a potent and selective aromatase inhibitor. ...In postmenopausal women, vorozole very potently inhibits peripheral conversion of androstenedione to estrone. ...
Vorozole, the (+)-(S)-isomer of a new triazole compound, is a potent and selective aromatase inhibitor. ...In postmenopausal women, …
Metastatic breast cancer.
Rubens RD. Rubens RD. Curr Opin Oncol. 1995 Nov;7(6):523-6. doi: 10.1097/00001622-199511000-00008. Curr Opin Oncol. 1995. PMID: 8547400 Review.
Aromatase inhibitors are an expanding field; formestane and vorozole are effective agents, and letrozole shows promise. In chemotherapy, major interest has focused on the use of taxoids, with high activity being reported for both paclitaxel and docetaxel, the latter being …
Aromatase inhibitors are an expanding field; formestane and vorozole are effective agents, and letrozole shows promise. In chemothera …
Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model.
Lubet RA, Steele VE, DeCoster R, Bowden C, You M, Juliana MM, Eto I, Kelloff GJ, Grubbs CJ. Lubet RA, et al. Carcinogenesis. 1998 Aug;19(8):1345-51. doi: 10.1093/carcin/19.8.1345. Carcinogenesis. 1998. PMID: 9744527
Serum level determinations were performed on a variety of endpoints at either 4 or 24 h following the last dose of vorozole. Insulin-like growth factor (IGF)-1 levels were slightly, but significantly, increased by vorozole treatment. ...This result presumably reflec …
Serum level determinations were performed on a variety of endpoints at either 4 or 24 h following the last dose of vorozole. Insulin- …
Pharmacology of vorozole.
Wouters W, Van Ginckel R, Krekels M, Bowden C, De Coster R. Wouters W, et al. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):617-21. doi: 10.1016/0960-0760(93)90268-2. J Steroid Biochem Mol Biol. 1993. PMID: 8386540
Vorozole (R83842) is a potent and selective, non-steroidal aromatase inhibitor. It is the dextro-enantiomer of the triazole derivative R 76,713. In FSH-stimulated rat granulosa cells, vorozole inhibited aromatase activity with an IC50-value of 1.4 +/- 0.5 nM. ...
Vorozole (R83842) is a potent and selective, non-steroidal aromatase inhibitor. It is the dextro-enantiomer of the triazole derivativ …
Effect of vorozole, an aromatase enzyme inhibitor, on sexual behavior, aromatase activity and neural immunoreactivity.
Rissman EF, Harada N, Roselli CE. Rissman EF, et al. J Neuroendocrinol. 1996 Mar;8(3):199-210. doi: 10.1046/j.1365-2826.1996.04505.x. J Neuroendocrinol. 1996. PMID: 8730654
In addition, vorozole treatment lowers aromatase activity in male and female preoptic area, and reduces plasma estradiol concentrations in females. Our findings confirm and extend results demonstrated in other species, conducted with the active enantiomer (R83842), or the …
In addition, vorozole treatment lowers aromatase activity in male and female preoptic area, and reduces plasma estradiol concentratio …
166 results