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Immunomodulatory effect of a newly synthesized compound, TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo [2,1-b]thiazole-2-carboxamide) on antibody production in vivo and delayed-type hypersensitivity in mice.
Shibata K, Kobayashi T, Takayanagi N, Fujiwara M, Yamamoto I. Shibata K, et al. Int J Immunopharmacol. 1990;12(5):497-502. doi: 10.1016/0192-0561(90)90112-z. Int J Immunopharmacol. 1990. PMID: 2210913
These immunopharmacological actions of TOK-8801 were compared in dose and activity with those of lobenzarit and bucillamine. Thus, these results suggest that TOK-8801 may act as an immunomodulating agent and would be expected to be a useful agent for a …
These immunopharmacological actions of TOK-8801 were compared in dose and activity with those of lobenzarit and bucillamine. T …
Immunomodulatory activity of the newly synthesized compound TOK-8801 (N-(2-phenylethyl)-3,6,6-trimethyl-5,6-dihydroimidazo[2,1-b]thiazole-2- carboxamide).
Fujiwara M, Shibata K, Takayanagi N, Matsunari K, Yamamoto I. Fujiwara M, et al. Jpn J Pharmacol. 1989 Dec;51(4):549-54. doi: 10.1254/jjp.51.549. Jpn J Pharmacol. 1989. PMID: 2615047 Free article.
The stimulatory effect of TOK-8801 as well as LMS on the antibody production was eliminated by the removal of T cells. ...From these results, TOK-8801 was shown to have an immunomodulatory activity in the antibody production....
The stimulatory effect of TOK-8801 as well as LMS on the antibody production was eliminated by the removal of T cells. ...From …