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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 3
1971 4
1972 10
1973 8
1974 13
1975 15
1976 28
1977 43
1978 19
1979 24
1980 21
1981 21
1982 8
1983 15
1984 16
1985 15
1986 13
1987 6
1988 10
1989 6
1990 9
1991 10
1992 6
1993 2
1994 4
1995 6
1996 9
1997 3
1998 6
1999 1
2000 6
2001 7
2002 8
2003 1
2004 4
2005 5
2006 4
2007 7
2008 9
2009 1
2010 3
2011 4
2012 6
2013 8
2014 2
2015 3
2016 3
2017 1
2018 5
2019 6
2020 12
2021 7
2022 4
2023 6
2024 0

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469 results

Results by year

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Page 1
Tilorone increases glucose uptake in vivo and in skeletal muscle cells by enhancing Akt2/AS160 signaling and glucose transporter levels.
Kohler ZM, Trencsenyi G, Juhasz L, Zvara A, Szabo JP, Dux L, Puskas LG, Rovo L, Keller-Pinter A. Kohler ZM, et al. J Cell Physiol. 2023 May;238(5):1080-1094. doi: 10.1002/jcp.30998. Epub 2023 Apr 3. J Cell Physiol. 2023. PMID: 37012691
Tilorone increased bone morphogenetic protein (BMP) signaling in C2C12 myoblasts, the transcription of multiple BMPs (BMP2, BMP4, BMP7, and BMP14), Smad4 expression, and the phosphorylation of BMP-mediated Smad1/5/8. ...Importantly, during in vivo experiments, the systemic …
Tilorone increased bone morphogenetic protein (BMP) signaling in C2C12 myoblasts, the transcription of multiple BMPs (BMP2, BMP4, BMP …
Tilorone hydrochloride: the drug profile.
Chandra P, Wright GJ. Chandra P, et al. Top Curr Chem. 1977;72:125-48. doi: 10.1007/BFb0048451. Top Curr Chem. 1977. PMID: 339405 Review. No abstract available.
Novel anti-inflammatory agents.
Cullen E. Cullen E. J Pharm Sci. 1984 May;73(5):579-89. doi: 10.1002/jps.2600730503. J Pharm Sci. 1984. PMID: 6429314 Review. No abstract available.
Prevention of tilorone developmental toxicity with progesterone.
Terry RD, Marks TA, Hamilton RD, Pitts TW, Renis HE. Terry RD, et al. Teratology. 1992 Sep;46(3):237-50. doi: 10.1002/tera.1420460307. Teratology. 1992. PMID: 1523581
In experiment 1, tilorone (250 or 500 mg/kg) was administered on day 10 of gestation. ...In experiment 2, the test groups received progesterone (2 mg/kg), or tilorone (200 or 400 mg/kg), or progesterone and tilorone. The dams from each group were killed 24 or …
In experiment 1, tilorone (250 or 500 mg/kg) was administered on day 10 of gestation. ...In experiment 2, the test groups received pr …
Osteopenia in rats with drug-induced mucopolysaccharidosis.
Lüllmann-Rauch R, Peters A, Schleicher A. Lüllmann-Rauch R, et al. Arzneimittelforschung. 1992 Apr;42(4):559-66. Arzneimittelforschung. 1992. PMID: 1642683
The immunostimulatory drug tilorone (CAS 27591-97-5) induces generalized lysosomal storage of sulfated glycosaminoglycans, i.e., mucopolysaccharidosis (MPS) in rats. ...Rats (initial age 4 weeks) were orally treated with tilorone (60-80 mg/kg; 6-25 weeks). The proxi …
The immunostimulatory drug tilorone (CAS 27591-97-5) induces generalized lysosomal storage of sulfated glycosaminoglycans, i.e., muco …
Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection.
Ekins S, Lingerfelt MA, Comer JE, Freiberg AN, Mirsalis JC, O'Loughlin K, Harutyunyan A, McFarlane C, Green CE, Madrid PB. Ekins S, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01711-17. doi: 10.1128/AAC.01711-17. Print 2018 Feb. Antimicrob Agents Chemother. 2018. PMID: 29133569 Free PMC article.
Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug that is used clinically as an antiviral outside the United States. A machine-learning model trained on anti-Ebola virus (EBOV) screening data previously identified tilorone as a …
Tilorone dihydrochloride (tilorone) is a small-molecule, orally bioavailable drug that is used clinically as an antiviral outs …
The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase.
Vignaux PA, Minerali E, Lane TR, Foil DH, Madrid PB, Puhl AC, Ekins S. Vignaux PA, et al. Chem Res Toxicol. 2021 May 17;34(5):1296-1307. doi: 10.1021/acs.chemrestox.0c00466. Epub 2021 Jan 5. Chem Res Toxicol. 2021. PMID: 33400519 Free PMC article.
We have described how tilorone inhibits both eel and human AChE with IC(50)'s of 14.4 nM and 64.4 nM, respectively, but does not inhibit the closely related BuChE IC(50) > 50 muM. ...This study suggests there may be a potential role for repurposing tilorone or it …
We have described how tilorone inhibits both eel and human AChE with IC(50)'s of 14.4 nM and 64.4 nM, respectively, but does not inhi …
Pre-Sézary syndrome.
Winkelmann RK, Buechner SA, Diaz-Perez JL. Winkelmann RK, et al. J Am Acad Dermatol. 1984 Jun;10(6):992-9. doi: 10.1016/s0190-9622(84)80321-7. J Am Acad Dermatol. 1984. PMID: 6234331
Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles.
Kaushik D, Kaur A, Petrovsky N, Salunke DB. Kaushik D, et al. RSC Med Chem. 2021 May 14;12(7):1065-1120. doi: 10.1039/d1md00031d. eCollection 2021 Jul 21. RSC Med Chem. 2021. PMID: 34355178 Free PMC article. Review.
Several synthetic heterocyclic small molecules like imiquimod, resiquimod, CL097, CL075, bromopirone, tilorone, loxoribine and isatoribine demonstrated TLR7/8 agonistic activity and relatively modest structural changes in such molecules result in major variation in the TLR …
Several synthetic heterocyclic small molecules like imiquimod, resiquimod, CL097, CL075, bromopirone, tilorone, loxoribine and isator …
469 results