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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 4
1966 2
1967 1
1968 1
1969 1
1972 1
1975 5
1976 3
1977 1
1978 5
1979 1
1980 9
1981 2
1982 2
1983 3
1984 2
1985 2
1986 6
1987 3
1988 2
1989 3
1990 4
1991 6
1992 1
1993 2
1995 2
1996 2
1997 1
1998 2
1999 1
2000 1
2001 2
2002 2
2003 2
2004 2
2005 1
2006 1
2007 2
2009 1
2010 1
2011 1
2012 5
2013 3
2014 1
2015 4
2016 3
2017 1
2019 2
2020 4
2021 5
2022 2
2023 4
2024 0

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126 results

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Page 1
Modified ELISA for Ultrasensitive Diagnosis.
Tsurusawa N, Chang J, Namba M, Makioka D, Yamura S, Iha K, Kyosei Y, Watabe S, Yoshimura T, Ito E. Tsurusawa N, et al. J Clin Med. 2021 Nov 7;10(21):5197. doi: 10.3390/jcm10215197. J Clin Med. 2021. PMID: 34768717 Free PMC article. Review.
Finally, we introduce our own newly devised system for ultrasensitive ELISA combined with thionicotinamide adenine dinucleotide cycling and its application for the diagnosis of infectious diseases and lifestyle-related diseases. ...
Finally, we introduce our own newly devised system for ultrasensitive ELISA combined with thionicotinamide adenine dinucleotide cycli …
Early diagnosis with ultrasensitive ELISA.
Ito E, Iha K, Yoshimura T, Nakaishi K, Watabe S. Ito E, et al. Adv Clin Chem. 2021;101:121-133. doi: 10.1016/bs.acc.2020.06.002. Epub 2020 Jul 7. Adv Clin Chem. 2021. PMID: 33706887 Review.
In this chapter, we introduce an ultrasensitive enzyme-linked immunosorbent assay (ELISA) which combines a traditional sandwich-based immunoassay with thionicotinamide adenine dinucleotide (thio-NAD) cycling. The performance characteristics of this unique approach are revi …
In this chapter, we introduce an ultrasensitive enzyme-linked immunosorbent assay (ELISA) which combines a traditional sandwich-based immuno …
Ultrasensitive ELISA Developed for Diagnosis.
Iha K, Inada M, Kawada N, Nakaishi K, Watabe S, Tan YH, Shen C, Ke LY, Yoshimura T, Ito E. Iha K, et al. Diagnostics (Basel). 2019 Jul 18;9(3):78. doi: 10.3390/diagnostics9030078. Diagnostics (Basel). 2019. PMID: 31323782 Free PMC article. Review.
This ultrasensitive assay consists of a sandwich enzyme-linked immunosorbent assay (ELISA) and thionicotinamide-adenine dinucleotide (thio-NAD) cycling, forming an ultrasensitive ELISA, in which the signal substrate (i.e., thio-NADH) accumulates in a triangular manner, and …
This ultrasensitive assay consists of a sandwich enzyme-linked immunosorbent assay (ELISA) and thionicotinamide-adenine dinucleotide …
Suppression of Cytosolic NADPH Pool by Thionicotinamide Increases Oxidative Stress and Synergizes with Chemotherapy.
Tedeschi PM, Lin H, Gounder M, Kerrigan JE, Abali EE, Scotto K, Bertino JR. Tedeschi PM, et al. Mol Pharmacol. 2015 Oct;88(4):720-7. doi: 10.1124/mol.114.096727. Epub 2015 Jul 28. Mol Pharmacol. 2015. PMID: 26219913 Free PMC article.
In vitro and in vivo inhibition of NADK with either small-hairpin RNA or thionicotinamide inhibited proliferation. Thionicotinamide enhanced the ROS produced by several chemotherapeutic drugs and produced synergistic cell kill. ...
In vitro and in vivo inhibition of NADK with either small-hairpin RNA or thionicotinamide inhibited proliferation. Thionicotinamid …
Validation of target protein PcnWAS in Pomacea canaliculata and screening of target-based molluscicidal compounds.
Ma Y, Chen H, Yang C, Zhang M, Gong G, Chang X, Jiang C, Yue G, Qiu X, Luo L. Ma Y, et al. Pestic Biochem Physiol. 2023 May;192:105424. doi: 10.1016/j.pestbp.2023.105424. Epub 2023 Apr 7. Pestic Biochem Physiol. 2023. PMID: 37105626
Results showed that, pedunsaponin A had high binding capacity with protein PcnWAS, and the binding constant (Ka) was 2.98 1.74 10(-4). A new potential molluscicidal compound thionicotinamide-adenine-dinucleotide (thionicotinamide-DPN) was obtained by virtual screeni …
Results showed that, pedunsaponin A had high binding capacity with protein PcnWAS, and the binding constant (Ka) was 2.98 1.74 10(-4). A new …
The metabolism of thionicotinamide in the rat.
Ruse MJ, Waring RH. Ruse MJ, et al. Drug Metabol Drug Interact. 1991;9(2):123-37. doi: 10.1515/dmdi.1991.9.2.123. Drug Metabol Drug Interact. 1991. PMID: 1839279
The metabolism of the thioamide, thionicotinamide, in the male Wistar rat is described. Thionicotinamide was shown to be metabolised to inorganic sulphate, thionicotinamide S-oxide and also N1-methylnicotinamide, which arises from N-methylation of nicotinamid …
The metabolism of the thioamide, thionicotinamide, in the male Wistar rat is described. Thionicotinamide was shown to be metab …
Electron transfer kinetics and mechanistic study of the thionicotinamide coordinated to the pentacyanoferrate(III)/(II) complexes: a model system for the in vitro activation of thioamides anti-tuberculosis drugs.
Sousa EH, Pontes DL, Diógenes IC, Lopes LG, Oliveira JS, Basso LA, Santos DS, Moreira IS. Sousa EH, et al. J Inorg Biochem. 2005 Feb;99(2):368-75. doi: 10.1016/j.jinorgbio.2004.10.004. J Inorg Biochem. 2005. PMID: 15621268
The reaction of the Fe(III) complex with thionicotinamide leads to the ligand conversion to the 3-cyanopyridine species coordinated to a Fe(II) metal center. The rate constant, k(et)=10 s(-1), was determined for this intra-molecular ET reaction. A kinetic study for the cro …
The reaction of the Fe(III) complex with thionicotinamide leads to the ligand conversion to the 3-cyanopyridine species coordinated t …
Non-amplification nucleic acid detection with thio-NAD cycling.
Yamura S, Kawada N, Yamakado S, Kyosei Y, Watabe S, Yoshimura T, Murase Y, Mitarai S, Ito E. Yamura S, et al. J Microbiol Methods. 2023 Jan;204:106647. doi: 10.1016/j.mimet.2022.106647. Epub 2022 Dec 7. J Microbiol Methods. 2023. PMID: 36496031
Ultrasensitive detection of proteins and sugars at single-cell level.
Watabe S, Morikawa M, Kaneda M, Nakaishi K, Nakatsuma A, Ninomiya M, Yoshimura T, Miura T, Ito E. Watabe S, et al. Commun Integr Biol. 2016 Jan 6;9(1):e1124201. doi: 10.1080/19420889.2015.1124201. eCollection 2016 Jan-Feb. Commun Integr Biol. 2016. PMID: 27064305 Free PMC article. Review.
For proteins, our ultrasensitive enzyme-linked immunosorbent assay (ELISA) coupled with thionicotinamide-adenine dinucleotide cycling can detect proteins at subattomoles per assay. ...
For proteins, our ultrasensitive enzyme-linked immunosorbent assay (ELISA) coupled with thionicotinamide-adenine dinucleotide cycling …
NAD+ Kinase as a Therapeutic Target in Cancer.
Tedeschi PM, Bansal N, Kerrigan JE, Abali EE, Scotto KW, Bertino JR. Tedeschi PM, et al. Clin Cancer Res. 2016 Nov 1;22(21):5189-5195. doi: 10.1158/1078-0432.CCR-16-1129. Epub 2016 Aug 31. Clin Cancer Res. 2016. PMID: 27582489 Review.
In this review, we will discuss the experimental evidence justifying further exploration of NADK as a clinically relevant drug target and describe our studies with a lead compound, thionicotinamide, an NADK inhibitor prodrug. Clin Cancer Res; 22(21); 5189-95. 2016 AACR....
In this review, we will discuss the experimental evidence justifying further exploration of NADK as a clinically relevant drug target and de …
126 results