Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 3
1966 6
1967 2
1968 1
1969 5
1970 1
1972 2
1973 3
1974 1
1975 4
1976 6
1977 3
1978 2
1979 1
1980 6
1981 3
1982 2
1983 8
1984 3
1985 7
1986 7
1987 6
1988 3
1989 6
1990 6
1991 5
1992 2
1993 5
1994 5
1995 3
1996 12
1997 8
1998 6
1999 6
2000 8
2001 7
2002 12
2003 8
2004 10
2005 13
2006 18
2007 6
2008 12
2009 16
2010 16
2011 23
2012 18
2013 18
2014 11
2015 14
2016 7
2017 12
2018 17
2019 18
2020 17
2021 22
2022 18
2023 18
2024 9

Text availability

Article attribute

Article type

Publication date

Search Results

448 results

Results by year

Filters applied: . Clear all
Page 1
Selenocystine and Photo-Irradiation Directed Growth of Helically Grooved Gold Nanoarrows.
Wen X, Wang S, Liu R, Duan R, Hu S, Jiao T, Zhang L, Liu M. Wen X, et al. Small. 2022 Feb;18(5):e2104301. doi: 10.1002/smll.202104301. Epub 2021 Nov 25. Small. 2022. PMID: 34825484
Here, gold nanoarrows (GNAs) with both chiroptical responses and chiral morphologies are achieved by using L-selenocystine (L-SeCys(2) ) as a chiral inducer. While L-SeCys(2) generates GNAs with a weak PCD signal, the irradiated L-SeCys(2) (irr-L-SeCys(2) ) leads to GNAs w …
Here, gold nanoarrows (GNAs) with both chiroptical responses and chiral morphologies are achieved by using L-selenocystine (L-SeCys(2 …
Selenocystine-Derived Label-Free Fluorescent Schiff Base Nanocomplex for siRNA Delivery Synergistically Kills Cancer Cells.
Liu Y, Yang H, Liu Q, Pan M, Wang D, Pan S, Zhang W, Wei J, Zhao X, Ji J. Liu Y, et al. Molecules. 2022 Feb 15;27(4):1302. doi: 10.3390/molecules27041302. Molecules. 2022. PMID: 35209090 Free PMC article.
In this study, we developed a nanocarrier for siRNA based on a selenocystine analog engineered polyetherimide and achieved traceable siRNA delivery and the synergic killing of tumor cells. Notably, we applied the label-free Schiff base fluorescence mechanism, which enabled …
In this study, we developed a nanocarrier for siRNA based on a selenocystine analog engineered polyetherimide and achieved traceable …
[Selenium methylation and toxicity mechanism of selenocystine].
Sayato Y, Nakamuro K, Hasegawa T. Sayato Y, et al. Yakugaku Zasshi. 1997 Nov;117(10-11):665-72. doi: 10.1248/yakushi1947.117.10-11_665. Yakugaku Zasshi. 1997. PMID: 9414580 Review. Japanese.
This review summarized recent studies on the toxicity mechanism of selenocystine in experimental animals. Hepatotoxicity is caused by repeated oral administration of selenocystine. Selenocystine is metabolized by reduced glutathione and/or glutathione reducta …
This review summarized recent studies on the toxicity mechanism of selenocystine in experimental animals. Hepatotoxicity is caused by …
Biomimetic selenocystine based dynamic combinatorial chemistry for thiol-disulfide exchange.
Canal-Martín A, Pérez-Fernández R. Canal-Martín A, et al. Nat Commun. 2021 Jan 8;12(1):163. doi: 10.1038/s41467-020-20415-6. Nat Commun. 2021. PMID: 33420034 Free PMC article.
Thiol-disulfide exchange, one of the most popular dynamic combinatorial chemistries, usually needs long equilibration times to reach the required equilibrium composition. Here we report selenocystine as a catalyst mimicking Nature's strategy to accelerate thiol-disulfide e …
Thiol-disulfide exchange, one of the most popular dynamic combinatorial chemistries, usually needs long equilibration times to reach the req …
Selenocystine induces oxidative-mediated DNA damage via impairing homologous recombination repair of DNA double-strand breaks in human hepatoma cells.
Wahyuni EA, Yii CY, Liang HL, Luo YH, Yang SH, Wu PY, Hsu WL, Nien CY, Chen SC. Wahyuni EA, et al. Chem Biol Interact. 2022 Sep 25;365:110046. doi: 10.1016/j.cbi.2022.110046. Epub 2022 Jul 19. Chem Biol Interact. 2022. PMID: 35863474
Selenocystine (SeC) has been identified as a novel compound with broad-spectrum anticancer activity. ...
Selenocystine (SeC) has been identified as a novel compound with broad-spectrum anticancer activity. ...
Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity.
Tan SLW, Tan HM, Israeli E, Fatihah I, Ramachandran V, Ali SB, Goh SJA, Wee J, Tan AQL, Tam WL, Han W. Tan SLW, et al. Biochem J. 2023 Dec 20;480(24):2045-2058. doi: 10.1042/BCJ20230317. Biochem J. 2023. PMID: 38078799
We find that the abundance of SLC7A11 positively correlates with sensitivity to l-selenocystine, but surprisingly, not to Erastin, an inhibitor of SLC7A11 activity. ...Hence, our findings raise the prospect of l-selenocystine administration as a novel strategy for t …
We find that the abundance of SLC7A11 positively correlates with sensitivity to l-selenocystine, but surprisingly, not to Erastin, an …
Selenocystine against methyl mercury cytotoxicity in HepG2 cells.
Wang H, Chen B, He M, Yu X, Hu B. Wang H, et al. Sci Rep. 2017 Mar 10;7(1):147. doi: 10.1038/s41598-017-00231-7. Sci Rep. 2017. PMID: 28273949 Free PMC article.
Until now, no related works have been reported from the view of the point of elemental speciation which is promising to study the mechanism at the molecular level. In this work, to reveal the effect of selenocystine (SeCys(2)) against MeHg cytotoxicity in HepG2 cells, a co …
Until now, no related works have been reported from the view of the point of elemental speciation which is promising to study the mechanism …
Rapid additive-free selenocystine-selenoester peptide ligation.
Mitchell NJ, Malins LR, Liu X, Thompson RE, Chan B, Radom L, Payne RJ. Mitchell NJ, et al. J Am Chem Soc. 2015 Nov 11;137(44):14011-4. doi: 10.1021/jacs.5b07237. Epub 2015 Nov 3. J Am Chem Soc. 2015. PMID: 26487084
We describe an unprecedented reaction between peptide selenoesters and peptide dimers bearing N-terminal selenocystine that proceeds in aqueous buffer to afford native amide bonds without the use of additives. The selenocystine-selenoester ligations are complete in …
We describe an unprecedented reaction between peptide selenoesters and peptide dimers bearing N-terminal selenocystine that proceeds …
Selenocystine induces reactive oxygen species-mediated apoptosis in human cancer cells.
Chen T, Wong YS. Chen T, et al. Biomed Pharmacother. 2009 Feb;63(2):105-13. doi: 10.1016/j.biopha.2008.03.009. Epub 2008 May 2. Biomed Pharmacother. 2009. PMID: 18511231
A panel of eight human cancer cell lines was shown to be susceptible to selenocystine, with IC(50) values ranging from 3.6 to 37.0 microM. Selenocystine induced dose-dependent apoptosis in A375, HepG2 and MCF7 cells was evaluated by flow cytometric analysis and anne …
A panel of eight human cancer cell lines was shown to be susceptible to selenocystine, with IC(50) values ranging from 3.6 to 37.0 mi …
Selenocystine-induced cell apoptosis and S-phase arrest inhibit human triple-negative breast cancer cell proliferation.
Long M, Wu J, Hao J, Liu W, Tang Y, Li X, Su H, Qiu W. Long M, et al. In Vitro Cell Dev Biol Anim. 2015 Nov;51(10):1077-84. doi: 10.1007/s11626-015-9937-4. Epub 2015 Jul 21. In Vitro Cell Dev Biol Anim. 2015. PMID: 26194802
New therapeutic approaches are urgently needed to improve the prognosis of TNBC. Here we demonstrated that a redox modulator, selenocystine (SeC), significantly inhibits TNBC cell proliferation in a dose- and time-dependent manner. ...
New therapeutic approaches are urgently needed to improve the prognosis of TNBC. Here we demonstrated that a redox modulator, selenocysti …
448 results