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1988 9
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1992 4
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166 results

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Page 1
Effects of alinidine (ST 567) on baroreceptor-heart rate reflexes and its interactions with clonidine on the baroreflex and on the sympathetic terminals of the isolated atrium.
Heinzow BG, Angus JA, Korner PI. Heinzow BG, et al. Eur J Pharmacol. 1982 Oct 22;84(3-4):177-87. doi: 10.1016/0014-2999(82)90200-x. Eur J Pharmacol. 1982. PMID: 7173318
Alinidine (ST 567), an N-allyl derivative of clonidine, slowed the heart rate of conscious rabbits by 41 +/- 2.3 (S.E.D.) b/min and reduced mean arterial pressure (MAP) by 6.4 +/- 1.4 mmHg (P less than 0.001). ...Intracisternal alinidine could be given
Alinidine (ST 567), an N-allyl derivative of clonidine, slowed the heart rate of conscious rabbits by 41 +/- 2.3 (S.E.D
Alinidine pharmacokinetics following acute and chronic dosing.
Harron DW, Arndts D, Shanks RG. Harron DW, et al. Br J Clin Pharmacol. 1982 Jun;13(6):821-7. doi: 10.1111/j.1365-2125.1982.tb01873.x. Br J Clin Pharmacol. 1982. PMID: 7093113 Free PMC article.
Urinary excretion of clonidine represented 0.1% of the administered dose of alinidine. 4 During administration of alinidine 40 mg daily for 8 days, peak and trough plasma levels reached steady state after day 2 (223.1 +/- 123.9 and 9.03 +/- 6.7 ng/ml respectively). …
Urinary excretion of clonidine represented 0.1% of the administered dose of alinidine. 4 During administration of alinidine 40 …
Alinidine in angina.
Meinertz T, Kasper W, Meier R, Wiegand U, Bechtold H, Förster I, Pop T, Jähnchen E. Meinertz T, et al. Clin Pharmacol Ther. 1983 Dec;34(6):770-6. doi: 10.1038/clpt.1983.248. Clin Pharmacol Ther. 1983. PMID: 6641092 Clinical Trial.
Alinidine--N-allyl-clonidine--reduces heart rate without blocking beta adrenoreceptors. ...Alinidine (40 mg three times a day) reduced the number of anginal attacks and the average number of nitroglycerine capsules consumed. ...
Alinidine--N-allyl-clonidine--reduces heart rate without blocking beta adrenoreceptors. ...Alinidine (40 mg three times a day)
An assessment of the contribution of clonidine metabolised from alinidine to the cardiovascular effects of alinidine.
Harron DW, Arndts D, Finch M, Shanks RG. Harron DW, et al. Br J Clin Pharmacol. 1983 Oct;16(4):451-5. doi: 10.1111/j.1365-2125.1983.tb02196.x. Br J Clin Pharmacol. 1983. PMID: 6626441 Free PMC article. Clinical Trial.
Blood samples were taken for measurement of concentrations of alinidine and clonidine during alinidine administration and of clonidine during clonidine dosing. ...Clonidine plasma concentrations reached 0.3 +/- 0.11 ng/ml 6 h after alinidine 40 mg on day 1, a …
Blood samples were taken for measurement of concentrations of alinidine and clonidine during alinidine administration and of c …
Electrophysiological effects of alinidine (ST 567) on sinoatrial node fibres in the rabbit heart.
Opthof T, Duivenvoorden JJ, Vanginneken AC, Jongsma HJ, Bouman LN. Opthof T, et al. Cardiovasc Res. 1986 Oct;20(10):727-39. doi: 10.1093/cvr/20.10.727. Cardiovasc Res. 1986. PMID: 3791339
This pacemaker shift concealed the response of the primary pacemaker to alinidine in low chlorine Tyrode. Blockade of the pacemaker current of if by caesium prevented neither the alinidine effect on the diastolic depolarisation completely nor its effect on the actio …
This pacemaker shift concealed the response of the primary pacemaker to alinidine in low chlorine Tyrode. Blockade of the pacemaker c …
Specific bradycardic agents--a novel pharmacological class?
Kobinger W, Lillie C. Kobinger W, et al. Eur Heart J. 1987 Dec;8 Suppl L:7-15. doi: 10.1093/eurheartj/8.suppl_l.7. Eur Heart J. 1987. PMID: 2897916 Review.
Data have been reviewed and presented which suggest that substances from two different chemical groups, congeners of alinidine and falipamil, respectively, can be described as representatives of a novel and distinct pharmacological class: specific bradycardic agents (SBAs) …
Data have been reviewed and presented which suggest that substances from two different chemical groups, congeners of alinidine and fa …
The effect of alinidine (St 567) on emotionally induced tachycardia in man.
Auböck J, Konzett H, Olbrich E. Auböck J, et al. Eur J Clin Pharmacol. 1982;21(6):467-71. doi: 10.1007/BF00542040. Eur J Clin Pharmacol. 1982. PMID: 7075652 Clinical Trial.
Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the stress of performing a mental task. Forearm blood flow and the efficiency (total score in the mental task) remained unchanged by alinidine
Alinidine 40 mg orally significantly (1%) reduced the tachycardia and the concomitant rise in diastolic blood pressure during the str
Bradycardic effect of alinidine on in situ and on isolated, blood-perfused heart preparations of dogs.
Ogiwara Y, Furukawa Y, Saegusa K, Takeda M, Chiba S. Ogiwara Y, et al. Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:41-54. Arch Int Pharmacodyn Ther. 1988. PMID: 2835022
Direct injection of alinidine (1-300 micrograms) into the sinus node artery of the isolated atrium induced predominant negative chronotropic responses at lower doses. In paced left ventricular muscle preparations, alinidine reduced the developed tension at higher do …
Direct injection of alinidine (1-300 micrograms) into the sinus node artery of the isolated atrium induced predominant negative chron …
Pacemaker selectivity: influence on rabbit atria of ionic environment and of alinidine, a possible anion antagonist.
Millar JS, Williams EM. Millar JS, et al. Cardiovasc Res. 1981 Jun;15(6):335-50. doi: 10.1093/cvr/15.6.335. Cardiovasc Res. 1981. PMID: 7296591
The dose-response relation between alinidine and frequency is not altered by atropine, and alinidine does not block the positive chronotropic action of isoprenaline. ...The effect of alinidine on frequency was not increased in 14 mmol . litre-1 KCl, or decrea …
The dose-response relation between alinidine and frequency is not altered by atropine, and alinidine does not block the positi …
Cardiovascular effects of alinidine and propranolol alone and in combination with hydralazine in normal man.
Nicholls DP, Harron DW, Shanks RG. Nicholls DP, et al. Br J Clin Pharmacol. 1983 Jan;15(1):21-9. doi: 10.1111/j.1365-2125.1983.tb01458.x. Br J Clin Pharmacol. 1983. PMID: 6849740 Free PMC article. Clinical Trial.
The reductions in supine heart rate produced by alinidine and propranolol were not significantly different, but the maximum effect of alinidine on exercise heart rate was observed later than that of propranolol. ...The effects of hydralazine and alinidine com …
The reductions in supine heart rate produced by alinidine and propranolol were not significantly different, but the maximum effect of …
166 results