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1994 3
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54 results

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Page 1
Antagonism of neuronal prostaglandin E(2) receptor subtype 1 mitigates amyloid β neurotoxicity in vitro.
Li X, Rose SE, Montine KS, Keene CD, Montine TJ. Li X, et al. J Neuroimmune Pharmacol. 2013 Mar;8(1):87-93. doi: 10.1007/s11481-012-9380-1. Epub 2012 Jun 21. J Neuroimmune Pharmacol. 2013. PMID: 22718277 Free PMC article. Review.
We hypothesized that PGE(2) receptor subtype 1 (EP1) signaling (linked to intracellular Ca(2+) release) regulates Abeta peptide neurotoxicity and tested this in two complementary in vitro models: a human neuroblastoma cell line (MC65) producing Abeta(1-40) through conditional exp …
We hypothesized that PGE(2) receptor subtype 1 (EP1) signaling (linked to intracellular Ca(2+) release) regulates Abeta peptide neurotoxicit …
Comparative metabolism of SC-42867 and SC-51089, two PGE2 antagonists, in rat and human hepatocyte cultures.
Lee K, Vandenberghe Y, Herin M, Cavalier R, Beck D, Li A, Verbeke N, Lesne M, Roba J. Lee K, et al. Xenobiotica. 1994 Jan;24(1):25-36. doi: 10.3109/00498259409043218. Xenobiotica. 1994. PMID: 8165819
1. The metabolism of SC-42867 and SC-51089, two PGE2 antagonists, was studied in cultured rat and human hepatocytes. ...However, the compound was metabolized to a much lower extent by the human cells. 3. SC-51089 was extensively metabolized by both cul …
1. The metabolism of SC-42867 and SC-51089, two PGE2 antagonists, was studied in cultured rat and human hepatocytes. ...Howeve …
Role of the prostaglandin E2 EP1 receptor in traumatic brain injury.
Glushakov AV, Fazal JA, Narumiya S, Doré S. Glushakov AV, et al. PLoS One. 2014 Nov 26;9(11):e113689. doi: 10.1371/journal.pone.0113689. eCollection 2014. PLoS One. 2014. PMID: 25426930 Free PMC article.
The therapeutic effects of post-treatments with a widely studied EP1 receptor antagonist, SC-51089, were examined in wildtype and EP1 receptor knockout C57BL/6 mice. ...In wildtype mice, CCI resulted in an obvious cortical lesion and localized hippocampal edema with …
The therapeutic effects of post-treatments with a widely studied EP1 receptor antagonist, SC-51089, were examined in wildtype …
Alcohol reinstatement after prolonged abstinence from alcohol drinking by female adolescent rats: Roles of cyclooxygenase-2 and the prostaglandin E2 receptor 1.
Kline HL, Yamamoto BK. Kline HL, et al. Drug Alcohol Depend. 2022 Jul 1;236:109491. doi: 10.1016/j.drugalcdep.2022.109491. Epub 2022 May 6. Drug Alcohol Depend. 2022. PMID: 35537317
The COX-2 inhibitor nimesulide was then administered during abstinence prior to an EtOH reinstatement or sucrose preference or to measure PGE(2) content. The PGE(2) receptor 1 (EP(1)) antagonist SC-51089 was then administered prior to EtOH reinstatement during which …
The COX-2 inhibitor nimesulide was then administered during abstinence prior to an EtOH reinstatement or sucrose preference or to measure PG …
Obligatory Role of EP1 Receptors in the Increase in Cerebral Blood Flow Produced by Hypercapnia in the Mice.
Uekawa K, Koizumi K, Hwang J, Brunier N, Hattori Y, Zhou P, Park L. Uekawa K, et al. PLoS One. 2016 Sep 22;11(9):e0163329. doi: 10.1371/journal.pone.0163329. eCollection 2016. PLoS One. 2016. PMID: 27657726 Free PMC article.
In WT mice, neocortical application of the EP1 receptor antagonist SC-51089 attenuated the increase in CBF elicited by systemic hypercapnia (pCO2 = 50-60 mmHg). SC-51089 also attenuated the increase in CBF produced by neocortical treatment of arachidon …
In WT mice, neocortical application of the EP1 receptor antagonist SC-51089 attenuated the increase in CBF elicited by systemi …
Prostaglandin E2 receptor 1 activity regulates cell survival following hypoxia in cultured rat cortical neurons.
Liu ML, Zhang YQ, Zhang YN, Pei LC, Liu X. Liu ML, et al. Neurosci Lett. 2012 Feb 2;508(1):31-6. doi: 10.1016/j.neulet.2011.12.010. Epub 2011 Dec 17. Neurosci Lett. 2012. PMID: 22198374
To determine the effects of EP1 activity on Hyp-induced neurotoxicity, cells were treated with 17-phenyl trinor-PGE2 (17-pt), a synthetic EP1 agonist, or sc-51089, an EP1 antagonist, then exposed to hypoxic conditions for 3h and reoxygenated for 21 h. ...However, cy …
To determine the effects of EP1 activity on Hyp-induced neurotoxicity, cells were treated with 17-phenyl trinor-PGE2 (17-pt), a synthetic EP …
Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs.
Hallinan EA, Hagen TJ, Tsymbalov S, Husa RK, Lee AC, Stapelfeld A, Savage MA. Hallinan EA, et al. J Med Chem. 1996 Jan 19;39(2):609-13. doi: 10.1021/jm950454k. J Med Chem. 1996. PMID: 8558534
8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride (1, SC-51089) is a functional PGE2 antagonist selective for the EP1 receptor subtype with antinociceptive activity. During metabolism in cultured r …
8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide, monohydrochloride (1, SC-5108 …
3,4-methylenedioxymethamphetamine increases excitability in the dentate gyrus: role of 5HT2A receptor-induced PGE2 signaling.
Collins SA, Huff C, Chiaia N, Gudelsky GA, Yamamoto BK. Collins SA, et al. J Neurochem. 2016 Mar;136(5):1074-84. doi: 10.1111/jnc.13493. Epub 2016 Jan 19. J Neurochem. 2016. PMID: 26670377 Free PMC article.
MDMA-induced increases in extracellular glutamate were inhibited by local administration of SC-51089, an inhibitor of the EP1 prostaglandin receptor. Systemic administration of SC-51089 during injections of MDMA prevented the decreases in parvalbumin i …
MDMA-induced increases in extracellular glutamate were inhibited by local administration of SC-51089, an inhibitor of the EP1 …
Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice.
Fischborn SV, Soerensen J, Potschka H. Fischborn SV, et al. Epilepsy Res. 2010 Sep;91(1):57-65. doi: 10.1016/j.eplepsyres.2010.06.012. Epub 2010 Jul 24. Epilepsy Res. 2010. PMID: 20655707
Therefore we evaluated the impact of the EP1 receptor antagonist SC-51089, the EP1 receptor agonist misoprostol and the COX-2 inhibitors celecoxib and NS-398 in the mouse amygdala kindling model of temporal lobe epilepsy. ...Moreover, SC-51089 signific …
Therefore we evaluated the impact of the EP1 receptor antagonist SC-51089, the EP1 receptor agonist misoprostol and the COX-2 …
Prostaglandin E2 EP1 receptor antagonist improves motor deficits and rescues memory decline in R6/1 mouse model of Huntington's disease.
Anglada-Huguet M, Xifró X, Giralt A, Zamora-Moratalla A, Martín ED, Alberch J. Anglada-Huguet M, et al. Mol Neurobiol. 2014 Apr;49(2):784-95. doi: 10.1007/s12035-013-8556-x. Epub 2013 Nov 7. Mol Neurobiol. 2014. PMID: 24198227
To this aim, we implanted an osmotic mini-pump system to chronically administrate an EP1 receptor antagonist (SC-51089) in the R6/1 mouse model of HD, from 13 to 18 weeks of age, and used different paradigms to assess motor and memory function. SC-51089 …
To this aim, we implanted an osmotic mini-pump system to chronically administrate an EP1 receptor antagonist (SC-51089) in the …
54 results