Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2000 3
2001 4
2002 3
2003 3
2004 4
2005 3
2006 5
2007 2
2008 3
2010 1
2012 1
2013 2
2018 1
2021 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

34 results

Results by year

Filters applied: . Clear all
Page 1
An overview of inhibitors of Na(+)/H(+) exchanger.
Masereel B, Pochet L, Laeckmann D. Masereel B, et al. Eur J Med Chem. 2003 Jun;38(6):547-54. doi: 10.1016/s0223-5234(03)00100-4. Eur J Med Chem. 2003. PMID: 12832126 Review.
In the last decade several bicyclic guanidines were prepared: zoniporide, MS-31038, SM-20220, SM-20550, SMP-300, KB-R9032, BMS-284640, T-162559, TY-12533, S-3226 or SL-591227. Extensive pre-clinical studies indicated that NHE inhibitors afford substantial protection …
In the last decade several bicyclic guanidines were prepared: zoniporide, MS-31038, SM-20220, SM-20550, SMP-300, KB-R9032, BMS-284640, T-162 …
OSR1-sensitive small intestinal Na+ transport.
Pasham V, Pathare G, Fajol A, Rexhepaj R, Michael D, Pakladok T, Alesutan I, Rotte A, Föller M, Lang F. Pasham V, et al. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 1;303(11):G1212-9. doi: 10.1152/ajpgi.00367.2011. Epub 2012 Sep 27. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 23019198 Free article.
Daily fecal Na(+), K(+), and H(2)O excretion and jejunal SGLT1 activity were lower, whereas small intestinal NHE activity and colonic ENaC activity were higher in osr1(+/KI) mice than in osr1(+/+) mice. NHE3 inhibitor S-3226 significantly reduced NHE activity in bot …
Daily fecal Na(+), K(+), and H(2)O excretion and jejunal SGLT1 activity were lower, whereas small intestinal NHE activity and colonic ENaC a …
Role of NHE isoforms in mediating bicarbonate reabsorption along the nephron.
Wang T, Hropot M, Aronson PS, Giebisch G. Wang T, et al. Am J Physiol Renal Physiol. 2001 Dec;281(6):F1117-22. doi: 10.1152/ajprenal.2001.281.6.F1117. Am J Physiol Renal Physiol. 2001. PMID: 11704563 Free article.
In the proximal tubule, addition of ethylisopropylamiloride or S-3226 significantly reduced J(v) and J(HCO3), but addition of Hoe-694 caused no significant inhibition. In the loop of Henle, J(HCO3) was also inhibited by S-3226 and not by Hoe-694, altho …
In the proximal tubule, addition of ethylisopropylamiloride or S-3226 significantly reduced J(v) and J(HCO3), but addition of …
Bicarbonate reabsorption and NHE-3 expression: abundance and activity are increased in Henle's loop of remnant rats.
Capasso G, Rizzo M, Pica A, Di Maio FS, Moe OW, Alpern RJ, De Santo NG. Capasso G, et al. Kidney Int. 2002 Dec;62(6):2126-35. doi: 10.1046/j.1523-1755.2002.00681.x. Kidney Int. 2002. PMID: 12427137 Free article.
Western blot experiments showed a significant increase of NHE-3 protein abundance in TAL of remnant rats as compared to sham-operated animals. Finally, by means of a specific NHE-3 inhibitor, S-3226, in vivo microperfusion experiments demonstrated that NHE-3 in vivo …
Western blot experiments showed a significant increase of NHE-3 protein abundance in TAL of remnant rats as compared to sham-operated animal …
NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo.
Gekle M, Völker K, Mildenberger S, Freudinger R, Shull GE, Wiemann M. Gekle M, et al. Am J Physiol Renal Physiol. 2004 Sep;287(3):F469-73. doi: 10.1152/ajprenal.00059.2004. Epub 2004 Apr 27. Am J Physiol Renal Physiol. 2004. PMID: 15113744 Free article.
We analyzed proximal tubular protein reabsorption by microinfusion experiments in rats and investigated renal protein excretion in NHE3 knockout (Nhe3 -/-) mice. Inhibition of NHE3 by EIPA or S-3226 reduced the fractional reabsorption of [(14)C]cytochrome c by appro …
We analyzed proximal tubular protein reabsorption by microinfusion experiments in rats and investigated renal protein excretion in NHE3 knoc …
Regulation of Na+/H+ exchanger-NHE3 by angiotensin-II in OKP cells.
Xu L, Dixit MP, Nullmeyer KD, Xu H, Kiela PR, Lynch RM, Ghishan FK. Xu L, et al. Biochim Biophys Acta. 2006 Apr;1758(4):519-26. doi: 10.1016/j.bbamem.2006.02.023. Epub 2006 Mar 20. Biochim Biophys Acta. 2006. PMID: 16603121 Free article.
To test this hypothesis, we utilized the proximal tubule-like OKP cell line to evaluate the effects of 16-h treatment with A-II on NHE3 activity and gene expression. A-II significantly stimulated NHE3-mediated, S-3226-sensitive Na+/H+ exchange. Inhibition of transcr …
To test this hypothesis, we utilized the proximal tubule-like OKP cell line to evaluate the effects of 16-h treatment with A-II on NHE3 acti …
NHE3-dependent cytoplasmic alkalinization is triggered by Na(+)-glucose cotransport in intestinal epithelia.
Turner JR, Black ED. Turner JR, et al. Am J Physiol Cell Physiol. 2001 Nov;281(5):C1533-41. doi: 10.1152/ajpcell.2001.281.5.C1533. Am J Physiol Cell Physiol. 2001. PMID: 11600416 Free article.
This increase occurred in parallel with glucose uptake and required expression of the intestinal Na(+)-glucose cotransporter SGLT1. S-3226, a preferential inhibitor of Na(+)/H(+) exchanger (NHE) isoform 3 (NHE3), prevented cytoplasmic alkalinization after initiation …
This increase occurred in parallel with glucose uptake and required expression of the intestinal Na(+)-glucose cotransporter SGLT1. S …
Prostaglandin-mediated inhibition of Na+/H+ exchanger isoform 2 stimulates recovery of barrier function in ischemia-injured intestine.
Moeser AJ, Nighot PK, Ryan KA, Wooten JG, Blikslager AT. Moeser AJ, et al. Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G885-94. doi: 10.1152/ajpgi.00380.2005. Epub 2006 Mar 30. Am J Physiol Gastrointest Liver Physiol. 2006. PMID: 16574991 Free article.
Inhibition of NHE2 with HOE-694 (25 microM) added to the mucosal surface of the injured ileum stimulated significant elevations in TER, independent of changes in I(sc) and histological evidence of restitution. Pharmacological inhibition of NHE3 or NHE1 with mucosal S-32 …
Inhibition of NHE2 with HOE-694 (25 microM) added to the mucosal surface of the injured ileum stimulated significant elevations in TER, inde …
Intestinal function of gene-targeted mice lacking serum- and glucocorticoid-inducible kinase 1.
Grahammer F, Henke G, Sandu C, Rexhepaj R, Hussain A, Friedrich B, Risler T, Metzger M, Just L, Skutella T, Wulff P, Kuhl D, Lang F. Grahammer F, et al. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1114-23. doi: 10.1152/ajpgi.00231.2005. Epub 2006 Jan 12. Am J Physiol Gastrointest Liver Physiol. 2006. PMID: 16410368 Free article.
Dex increased DeltapH(NHE) approximately threefold in sgk1(+/+) mice and approximately twofold in sgk1(-/-)mice, an effect significantly blunted in the presence of the specific NHE3 blocker S-3226 (10 microM). According to Western blot analysis, Dex significantly en …
Dex increased DeltapH(NHE) approximately threefold in sgk1(+/+) mice and approximately twofold in sgk1(-/-)mice, an effect significantly blu …
34 results