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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
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1969 1
1970 1
1971 1
1973 2
1975 9
1976 12
1977 9
1978 6
1979 4
1980 5
1981 4
1982 3
1983 4
1984 4
1985 5
1986 2
1987 4
1988 8
1989 2
1990 5
1991 3
1992 2
1993 6
1994 4
1995 2
1996 3
1998 1
1999 4
2000 5
2001 1
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2023 1
2024 0

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130 results

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Page 1
Monoamine-depleting drugs.
Carlsson A. Carlsson A. Pharmacol Ther B. 1975;1(3):393-400. doi: 10.1016/0306-039x(75)90045-8. Pharmacol Ther B. 1975. PMID: 772709 Review. No abstract available.
Effects of amfonelic acid, alpha-methyltyrosine, Ro 4-1284 and haloperidol pretreatment on the depletion of striatal dopamine by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.
Fuller RW, Hemrick-Luecke SK. Fuller RW, et al. Res Commun Chem Pathol Pharmacol. 1985 Apr;48(1):17-25. Res Commun Chem Pathol Pharmacol. 1985. PMID: 3873102
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) given in 4 daily s.c. injections to mice resulted in marked depletion of striatal dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) 1 week after the last dose. Pretreatment of mice with alpha-methyltyr …
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) given in 4 daily s.c. injections to mice resulted in marked depletion of striatal dopami …
2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents.
Kane JM, Dudley MW, Sorensen SM, Miller FP. Kane JM, et al. J Med Chem. 1988 Jun;31(6):1253-8. doi: 10.1021/jm00401a031. J Med Chem. 1988. PMID: 3373495
Several members of this series were potent antagonists of both RO 4-1284-induced hypothermia and reserpine-induced ptosis in mice. ...
Several members of this series were potent antagonists of both RO 4-1284-induced hypothermia and reserpine-induced ptos …
Brain norepinephrine and convulsions in the genetically epilepsy-prone rat: sex-dependent responses to Ro 4-1284 treatment.
Mishra PK, Dailey JW, Reigel CE, Jobe PC. Mishra PK, et al. Life Sci. 1988;42(11):1131-7. doi: 10.1016/0024-3205(88)90607-8. Life Sci. 1988. PMID: 3347143
Ro 4-1284 caused severe depletion of monoamines in all brain areas assayed in both sexes of GEPR-9s and also caused a reduction in the latencies for onset of running and convulsion. ...These observations prompt us to postulate that noradrenergic neurons in fe …
Ro 4-1284 caused severe depletion of monoamines in all brain areas assayed in both sexes of GEPR-9s and also caused a r …
Concurrent Inhibition of Vesicular Monoamine Transporter 2 Does Not Protect Against 3,4-Methylenedioxymethamphetamine (Ecstasy) Induced Neurotoxicity.
Cholanians AB, Phan AV, Lau SS, Monks TJ. Cholanians AB, et al. Toxicol Sci. 2019 Jul 1;170(1):157-166. doi: 10.1093/toxsci/kfz085. Toxicol Sci. 2019. PMID: 30923810 Free PMC article.
A similar body temperature response was observed in rats posttreated (7 h after MDMA) with Ro 4-1284. Despite decreases in the area under the curve (deltatemp X time) of body temperature caused by Ro 4-1284, there were no significant diff …
A similar body temperature response was observed in rats posttreated (7 h after MDMA) with Ro 4-1284. Despite decreases …
Amphetamine-induced reverse transport of dopamine does not require cytosolic Ca2.
Støier JF, Konomi-Pilkati A, Apuschkin M, Herborg F, Gether U. Støier JF, et al. J Biol Chem. 2023 Aug;299(8):105063. doi: 10.1016/j.jbc.2023.105063. Epub 2023 Jul 18. J Biol Chem. 2023. PMID: 37468107 Free PMC article.
In the presence of the Na(+)-channel blocker tetrodotoxin to prevent exocytotic DA release, AMPH induced in the cultured neurons a profound dose-dependent efflux of DA that was blocked both by inhibition of DAT with cocaine and by inhibition of the vesicular monoamine transporter …
In the presence of the Na(+)-channel blocker tetrodotoxin to prevent exocytotic DA release, AMPH induced in the cultured neurons a profound …
Depletion of epinephrine in rat hypothalamus by Ro 4-1284: influence of pargyline and harmaline.
Fuller RW, Hemrick-Luecke SK. Fuller RW, et al. Brain Res Bull. 1980 Sep-Oct;5(5):589-91. doi: 10.1016/0361-9230(80)90265-8. Brain Res Bull. 1980. PMID: 6903452
Ro 4-1284, 2-ethyl-2,3,4,6,7,11b-hexahydro-3 isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin-2-ol hydrochloride, depleted epinephrine in rat hypothalamus; the depletion occurred within 1 hr and persisted at 24 hr. The r …
Ro 4-1284, 2-ethyl-2,3,4,6,7,11b-hexahydro-3 isobutyl-9,10-dimethoxy-2H-benzo[a]quinolizin- …
Effects of Ro 4-1284 on electrically-induced spinal cord seizures and on spinal cord norepinephrine and 5-hydroxytryptamine levels.
Jobe PC, Ray TB, Geiger PF, Bourn WM. Jobe PC, et al. Res Commun Chem Pathol Pharmacol. 1977 Dec;18(4):601-12. Res Commun Chem Pathol Pharmacol. 1977. PMID: 243955
Forty-eight hours after injection, the effects of Ro 4-1284 on seizure and on NE levels are completely dissipated. A significant decrease in 5-HT levels is not apparent until 1 hour after Ro 4-1284. These data suggest that noradrenergic n …
Forty-eight hours after injection, the effects of Ro 4-1284 on seizure and on NE levels are completely dissipated. A si …
130 results