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1983 2
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Page 1
Monoclonal antibodies to benzodiazepines.
De Blas AL, Sangameswaran L, Haney SA, Park D, Abraham CJ Jr, Rayner CA. De Blas AL, et al. J Neurochem. 1985 Dec;45(6):1748-53. doi: 10.1111/j.1471-4159.1985.tb10530.x. J Neurochem. 1985. PMID: 2997395
Discriminative stimulus effects of diazepam in rats: evidence for a maximal effect.
Shannon HE, Herling S. Shannon HE, et al. J Pharmacol Exp Ther. 1983 Oct;227(1):160-6. J Pharmacol Exp Ther. 1983. PMID: 6137554
In rats trained with 1.0 mg/kg of diazepam, Ro 11-6896, but not its inactive stereoisomer Ro 11-6893, occasioned diazepam-appropriate responding. Furthermore, the selective benzodiazepine antagonist CGS8216 blocked the effects of diazepam but not the diazepam …
In rats trained with 1.0 mg/kg of diazepam, Ro 11-6896, but not its inactive stereoisomer Ro 11-6893, occasioned diazep …
Pharmacological characteristics of diazepam receptors in neurons and astrocytes in primary cultures.
Bender AS, Hertz L. Bender AS, et al. J Neurosci Res. 1987;18(2):366-72. doi: 10.1002/jnr.490180215. J Neurosci Res. 1987. PMID: 2891858
RO 5-4864, RO 7-3351, and, especially, the antagonist PK 11195 were much more potent in astrocytes than in neurons, whereas the opposite was true for the agonists alprazolam, clonazepam, flurazepam, RO 11-3128, and chlordiazepoxide, and, especially, the antagonists CGS-8216 and R …
RO 5-4864, RO 7-3351, and, especially, the antagonist PK 11195 were much more potent in astrocytes than in neurons, whereas the opposite was …
Discrimination of Ro 11-6896, chlordiazepoxide and ethanol in gerbils: generalization and antagonism tests.
Hiltunen AJ, Järbe TU. Hiltunen AJ, et al. Psychopharmacology (Berl). 1986;89(3):284-90. doi: 10.1007/BF00174360. Psychopharmacology (Berl). 1986. PMID: 3014593
Additional tests in the Ro 11-6896 group showed that this discrimination was stereoselective but not stereospecific in that the isomer Ro 11-6893 generalized to Ro 11-6896 at a dose of 10 mg/kg but not at 1 mg/kg; Ro 15-1788 attenuated this generalization. .. …
Additional tests in the Ro 11-6896 group showed that this discrimination was stereoselective but not stereospecific in that the isomer Ro
Benzodiazepine enhancement of gamma-aminobutyric acid-mediated chloride ion flux in rat brain synaptoneurosomes.
Morrow AL, Paul SM. Morrow AL, et al. J Neurochem. 1988 Jan;50(1):302-6. doi: 10.1111/j.1471-4159.1988.tb13264.x. J Neurochem. 1988. PMID: 3335847
These benzodiazepines had no effect on 36Cl-uptake in the absence of muscimol. Further, the inactive enantiomer, Ro 11-6893 [B10(-)], and the peripheral benzodiazepine receptor ligand Ro 5-4864 did not potentiate muscimol-stimulated 36Cl- uptake at concentrat …
These benzodiazepines had no effect on 36Cl-uptake in the absence of muscimol. Further, the inactive enantiomer, Ro 11-6893