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Year Number of Results
1995 3
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1997 2
1999 7
2000 11
2001 11
2002 6
2003 13
2004 14
2005 19
2006 22
2007 21
2008 26
2009 23
2010 26
2011 40
2012 52
2013 67
2014 45
2015 44
2016 44
2017 39
2018 51
2019 32
2020 45
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2023 34
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Page 1
Mechanisms of action of currently used antiseizure drugs.
Sills GJ, Rogawski MA. Sills GJ, et al. Neuropharmacology. 2020 May 15;168:107966. doi: 10.1016/j.neuropharm.2020.107966. Epub 2020 Jan 14. Neuropharmacology. 2020. PMID: 32120063 Review.
There are four broad classes of such ASD mechanisms: (1) modulation of voltage-gated sodium channels (e.g. phenytoin, carbamazepine, lamotrigine), voltage-gated calcium channels (e.g. ethosuximide), and voltage-gated potassium channels [e.g. retigabine (ezogabine)]; …
There are four broad classes of such ASD mechanisms: (1) modulation of voltage-gated sodium channels (e.g. phenytoin, carbamazepine, lamotri …
Use of antiepileptic drugs in hepatic and renal disease.
Asconapé JJ. Asconapé JJ. Handb Clin Neurol. 2014;119:417-32. doi: 10.1016/B978-0-7020-4086-3.00027-8. Handb Clin Neurol. 2014. PMID: 24365310 Review.
Drugs eliminated by a combination of renal excretion and biotransformation include levetiracetam, lacosamide, zonisamide, primidone, phenobarbital, ezogabine/retigabine, oxcarbazepine, eslicarbazepine, ethosuximide, and felbamate. ...
Drugs eliminated by a combination of renal excretion and biotransformation include levetiracetam, lacosamide, zonisamide, primidone, phenoba …
Update on Antiepileptic Drugs 2019.
Abou-Khalil BW. Abou-Khalil BW. Continuum (Minneap Minn). 2019 Apr;25(2):508-536. doi: 10.1212/CON.0000000000000715. Continuum (Minneap Minn). 2019. PMID: 30921021 Review.
RECENT FINDINGS: Since the previous version of this article was published, three new AEDs, brivaracetam, cannabidiol, and stiripentol, have been approved by the US Food and Drug Administration (FDA), and ezogabine was removed from the market because of decreased use as a r …
RECENT FINDINGS: Since the previous version of this article was published, three new AEDs, brivaracetam, cannabidiol, and stiripentol, have …
Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.
Wainger BJ, Macklin EA, Vucic S, McIlduff CE, Paganoni S, Maragakis NJ, Bedlack R, Goyal NA, Rutkove SB, Lange DJ, Rivner MH, Goutman SA, Ladha SS, Mauricio EA, Baloh RH, Simmons Z, Pothier L, Kassis SB, La T, Hall M, Evora A, Klements D, Hurtado A, Pereira JD, Koh J, Celnik PA, Chaudhry V, Gable K, Juel VC, Phielipp N, Marei A, Rosenquist P, Meehan S, Oskarsson B, Lewis RA, Kaur D, Kiskinis E, Woolf CJ, Eggan K, Weiss MD, Berry JD, David WS, Davila-Perez P, Camprodon JA, Pascual-Leone A, Kiernan MC, Shefner JM, Atassi N, Cudkowicz ME. Wainger BJ, et al. JAMA Neurol. 2021 Feb 1;78(2):186-196. doi: 10.1001/jamaneurol.2020.4300. JAMA Neurol. 2021. PMID: 33226425 Free PMC article. Clinical Trial.
RESULTS: A total of 65 participants were randomized to placebo (23), 600 mg/d of ezogabine (23), and 900 mg/d of ezogabine (19 participants); 45 were men (69.2%) and the mean (SD) age was 58.3 (8.8) years. ...Ezogabine caused a dose-dependent decrease in exci …
RESULTS: A total of 65 participants were randomized to placebo (23), 600 mg/d of ezogabine (23), and 900 mg/d of ezogabine (19 …
The interaction potential of retigabine (ezogabine) with other antiepileptic drugs.
Tompson DJ, Crean CS. Tompson DJ, et al. Curr Clin Pharmacol. 2014 May;9(2):148-56. doi: 10.2174/1574884708666131111192311. Curr Clin Pharmacol. 2014. PMID: 24219007 Review.
RESULTS: Retigabine is not a substrate for the major CYP enzymes and at clinically relevant concentrations there is little or no potential for retigabine to inhibit or induce the CYP enzymes or to inhibit the major renal drug transporters. ...Conversely, a populatio …
RESULTS: Retigabine is not a substrate for the major CYP enzymes and at clinically relevant concentrations there is little or no pote …
Ezogabine.
[No authors listed] [No authors listed] 2020 Sep 21. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2020 Sep 21. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 29999937 Free Books & Documents. Review.
Because no information is available on use of ezogabine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant. If ezogabine is required by the mother, it is not necessarily a reason to discontinue breastfeedin …
Because no information is available on use of ezogabine during breastfeeding, an alternate drug may be preferred, especially while nu …
Clinical pharmacokinetics of retigabine/ezogabine.
Tompson DJ, Crean CS. Tompson DJ, et al. Curr Clin Pharmacol. 2013 Nov;8(4):319-31. doi: 10.2174/15748847113089990053. Curr Clin Pharmacol. 2013. PMID: 23342983 Review.
RESULTS: Retigabine is rapidly absorbed with a median time to C(max) of 0.5-2.0 hours. ...Systemic exposure to retigabine is unaffected by gender when normalized for body weight. ...
RESULTS: Retigabine is rapidly absorbed with a median time to C(max) of 0.5-2.0 hours. ...Systemic exposure to retigabine is u …
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Lopez JP, Lücken MD, Brivio E, Karamihalev S, Kos A, De Donno C, Benjamin A, Yang H, Dick ALW, Stoffel R, Flachskamm C, Ressle A, Roeh S, Huettl RE, Parl A, Eggert C, Novak B, Yan Y, Yeoh K, Holzapfel M, Hauger B, Harbich D, Schmid B, Di Giaimo R, Turck CW, Schmidt MV, Deussing JM, Eder M, Dine J, Theis FJ, Chen A. Lopez JP, et al. Neuron. 2022 Jul 20;110(14):2283-2298.e9. doi: 10.1016/j.neuron.2022.05.001. Epub 2022 May 31. Neuron. 2022. PMID: 35649415 Free article.
We validated these findings through a series of complementary molecular, electrophysiological, cellular, pharmacological, behavioral, and functional experiments. We demonstrated that adjunctive treatment with retigabine, a KCNQ activator, augments ketamine's antidepressant …
We validated these findings through a series of complementary molecular, electrophysiological, cellular, pharmacological, behavioral, and fu …
Ezogabine (retigabine) and its role in the treatment of partial-onset seizures: a review.
Splinter MY. Splinter MY. Clin Ther. 2012 Sep;34(9):1845-56.e1. doi: 10.1016/j.clinthera.2012.07.009. Epub 2012 Aug 21. Clin Ther. 2012. PMID: 22917854 Review.
BACKGROUND: Ezogabine, also known as retigabine, is a recently approved anticonvulsant medication with a novel mechanism of action. ...METHODS: MEDLINE and EMBASE were systematically searched, using the search terms retigabine and ezogabine, for random …
BACKGROUND: Ezogabine, also known as retigabine, is a recently approved anticonvulsant medication with a novel mechanism of ac …
702 results