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Page 1
Gene therapy for RAB28: What can we learn from zebrafish?
Moran AL, Fehilly JD, Blacque O, Kennedy BN. Moran AL, et al. Vision Res. 2023 Sep;210:108270. doi: 10.1016/j.visres.2023.108270. Epub 2023 Jun 13. Vision Res. 2023. PMID: 37321111 Free article. Review.
Previous work demonstrated that restoring wild type zebrafish Rab28 via germline transgenesis, specifically in cone photoreceptors, is sufficient to rescue the defects in outer segment phagocytosis (OSP) observed in zebrafish rab28(-/-) knockouts (KO). This rescue s …
Previous work demonstrated that restoring wild type zebrafish Rab28 via germline transgenesis, specifically in cone photoreceptors, i …
Expression and cellular localization of rab28 mRNA and Rab28 protein during maize embryogenesis.
Niogret MF, Culiáñez-Macià FA, Goday A, Mar Albà M, Pagès M. Niogret MF, et al. Plant J. 1996 Apr;9(4):549-57. doi: 10.1046/j.1365-313x.1996.09040549.x. Plant J. 1996. PMID: 8624517 Free article.
The spatial and temporal pattern of rab28 mRNA expression during embryogenesis was investigated by in situ hybridization using digoxigenin-labelled rab28 probes, and the immunochemical localization of Rab28 protein using anti-Rab28 antibodies. . …
The spatial and temporal pattern of rab28 mRNA expression during embryogenesis was investigated by in situ hybridization using digoxi …
Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding.
Akella JS, Carter SP, Nguyen K, Tsiropoulou S, Moran AL, Silva M, Rizvi F, Kennedy BN, Hall DH, Barr MM, Blacque OE. Akella JS, et al. Elife. 2020 Feb 26;9:e50580. doi: 10.7554/eLife.50580. Elife. 2020. PMID: 32101165 Free PMC article.
Mechanisms driving ciliary EV biogenesis are almost entirely unknown. Here, we show that the ciliary G-protein Rab28, associated with human autosomal recessive cone-rod dystrophy, negatively regulates EV levels in the sensory organs of Caenorhabditis elegans in a ci …
Mechanisms driving ciliary EV biogenesis are almost entirely unknown. Here, we show that the ciliary G-protein Rab28, associat …
Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28.
Moran AL, Carter SP, Kaylor JJ, Jiang Z, Broekman S, Dillon ET, Gómez Sánchez A, Minhas SK, van Wijk E, Radu RA, Travis GH, Carey M, Blacque OE, Kennedy BN. Moran AL, et al. FASEB J. 2022 May;36(5):e22309. doi: 10.1096/fj.202101897R. FASEB J. 2022. PMID: 35471581 Free PMC article.
RAB28 is a farnesylated, ciliary G-protein. Patient variants in RAB28 are causative of autosomal recessive cone-rod dystrophy (CRD), an inherited human blindness. ...Notably, transgenic overexpression of Rab28, solely in zebrafish cones, rescues the OS …
RAB28 is a farnesylated, ciliary G-protein. Patient variants in RAB28 are causative of autosomal recessive cone-rod dys …
Rab28 function in trypanosomes: interactions with retromer and ESCRT pathways.
Lumb JH, Leung KF, Dubois KN, Field MC. Lumb JH, et al. J Cell Sci. 2011 Nov 15;124(Pt 22):3771-83. doi: 10.1242/jcs.079178. Epub 2011 Nov 18. J Cell Sci. 2011. PMID: 22100919 Free PMC article.
Rab28 is required for turnover of endocytosed proteins and for lysosomal delivery of protein cargo. Using RNA interference we find that in Rab28-depleted cells, protein levels of ESCRT I (Vps23/28) and retromer (Vps26) are also decreased, sugges …
Rab28 is required for turnover of endocytosed proteins and for lysosomal delivery of protein cargo. Using RNA interfere …
Prenylation defects in inherited retinal diseases.
Roosing S, Collin RW, den Hollander AI, Cremers FP, Siemiatkowska AM. Roosing S, et al. J Med Genet. 2014 Mar;51(3):143-51. doi: 10.1136/jmedgenet-2013-102138. Epub 2014 Jan 8. J Med Genet. 2014. PMID: 24401286 Review.
These include proteins involved in the phototransduction cascade, such as GRK1, the phosphodiesterase 6 subunits and the transducin gamma subunit, or proteins involved in transport processes, such as RAB28 and retinitis pigmentosa GTPase regulator (RPGR). In …
These include proteins involved in the phototransduction cascade, such as GRK1, the phosphodiesterase 6 subunits and the transducin g …
Enhanced water stress tolerance of transgenic maize plants over-expressing LEA Rab28 gene.
Amara I, Capellades M, Ludevid MD, Pagès M, Goday A. Amara I, et al. J Plant Physiol. 2013 Jun 15;170(9):864-73. doi: 10.1016/j.jplph.2013.01.004. Epub 2013 Feb 4. J Plant Physiol. 2013. PMID: 23384757
The expression of Rab28 transcripts led to the accumulation and stability of Rab28 protein in the transgenic plants. Native Rab28 protein is localized to nucleoli in wild type maize embryo cells; here we find by whole-mount immunocytochemistry t …
The expression of Rab28 transcripts led to the accumulation and stability of Rab28 protein in the transgenic plants. Na …
Genetic Deletion of Zebrafish Rab28 Causes Defective Outer Segment Shedding, but Not Retinal Degeneration.
Carter SP, Moran AL, Matallanas D, McManus GJ, Blacque OE, Kennedy BN. Carter SP, et al. Front Cell Dev Biol. 2020 Mar 17;8:136. doi: 10.3389/fcell.2020.00136. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32258030 Free PMC article.
Herein, we investigate the function and localization of the ciliary G-protein RAB28 in zebrafish cone photoreceptors. CRISPR-Cas9 generated rab28 mutant zebrafish display significantly reduced shed outer segment material/phagosomes in the RPE at 1 month post …
Herein, we investigate the function and localization of the ciliary G-protein RAB28 in zebrafish cone photoreceptors. CRISPR-C …
Involvement of Rab28 in NF-kappaB nuclear transport in endothelial cells.
Jiang J, Qi YX, Zhang P, Gu WT, Yan ZQ, Shen BR, Yao QP, Kong H, Chien S, Jiang ZL. Jiang J, et al. PLoS One. 2013;8(2):e56076. doi: 10.1371/journal.pone.0056076. Epub 2013 Feb 14. PLoS One. 2013. PMID: 23457503 Free PMC article.
Our previous proteomic analysis revealed the expression of Rab28 in arteries of rats. However, the function of Rab28 in mammalian cells, and its role in vessels are still unknown. ...Immunofluorescence revealed that Ang II stimulated the co-translocation of Rab28 …
Our previous proteomic analysis revealed the expression of Rab28 in arteries of rats. However, the function of Rab28 in mammal …
Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking.
Zhou Z, Menzel F, Benninghoff T, Chadt A, Du C, Holman GD, Al-Hasani H. Zhou Z, et al. FEBS Lett. 2017 Jan;591(1):88-96. doi: 10.1002/1873-3468.12509. Epub 2016 Dec 20. FEBS Lett. 2017. PMID: 27929607 Free article.
We identified Rab28 as a substrate for the GAP domains of both TBC1D1 and TBC1D4 in vitro. Rab28 is expressed in adipose cells and skeletal muscle, and its GTP-binding state is acutely regulated by insulin. ...
We identified Rab28 as a substrate for the GAP domains of both TBC1D1 and TBC1D4 in vitro. Rab28 is expressed in adipose cells …
40 results