Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 2
1969 1
1972 1
1974 2
1976 3
1977 1
1978 4
1979 1
1980 1
1981 2
1982 4
1983 3
1984 5
1985 3
1986 3
1987 2
1988 5
1989 1
1990 3
1991 3
1993 1
1994 1
1995 2
1996 3
1997 5
1998 6
1999 18
2000 28
2001 33
2002 50
2003 49
2004 47
2005 75
2006 47
2007 43
2008 41
2009 37
2010 38
2011 25
2012 22
2013 40
2014 54
2015 31
2016 26
2017 25
2018 33
2019 25
2020 26
2021 31
2022 22
2023 22
2024 7

Text availability

Article attribute

Article type

Publication date

Search Results

870 results

Results by year

Filters applied: . Clear all
Page 1
Allopurinol.
[No authors listed] [No authors listed] 2022 Mar 21. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2022 Mar 21. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000257 Free Books & Documents. Review.
Pyrazolo[3,4-d]pyrimidine scaffold: A review on synthetic approaches and EGFR and VEGFR inhibitory activities.
Kassab AE. Kassab AE. Arch Pharm (Weinheim). 2023 Jan;356(1):e2200424. doi: 10.1002/ardp.202200424. Epub 2022 Oct 3. Arch Pharm (Weinheim). 2023. PMID: 36192144 Review.
The pyrazolo[3,4-d]pyrimidine core has received a lot of interest from the medicinal chemistry community as a promising framework for drug design and discovery. ...Many successful anticancer medicines have been designed and synthesized using …
The pyrazolo[3,4-d]pyrimidine core has received a lot of interest from the medicinal chemistry community …
Novel pyrazolo[3,4-d]pyrimidine derivatives: design, synthesis, anticancer evaluation, VEGFR-2 inhibition, and antiangiogenic activity.
Abdelhamed AM, Hassan RA, Kadry HH, Helwa AA. Abdelhamed AM, et al. RSC Med Chem. 2023 Nov 7;14(12):2640-2657. doi: 10.1039/d3md00476g. eCollection 2023 Dec 13. RSC Med Chem. 2023. PMID: 38107182
A novel series of 12 pyrazolo[3,4-d]pyrimidine derivatives were created and evaluated in vitro for their antiproliferative activity against the NCI 60 human tumor cell line panel. ...
A novel series of 12 pyrazolo[3,4-d]pyrimidine derivatives were created and evaluated in vitro for their …
Revisiting Pyrazolo[3,4-d]pyrimidine Nucleosides as Anti-Trypanosoma cruzi and Antileishmanial Agents.
Bouton J, Ferreira de Almeida Fiuza L, Cardoso Santos C, Mazzarella MA, Soeiro MNC, Maes L, Karalic I, Caljon G, Van Calenbergh S. Bouton J, et al. J Med Chem. 2021 Apr 8;64(7):4206-4238. doi: 10.1021/acs.jmedchem.1c00135. Epub 2021 Mar 30. J Med Chem. 2021. PMID: 33784107
Earlier optimization efforts of the natural product tubercidin (7-deazaadenosine) involving modifications to the nucleobase 7-position and the ribofuranose 3'-position led to analogues with potent anti-Trypanosoma brucei and anti-Trypanosoma cruzi activities. In this work, we rep …
Earlier optimization efforts of the natural product tubercidin (7-deazaadenosine) involving modifications to the nucleobase 7-position and t …
4-Benzyl-sulfanyl-1H-pyrazolo-[3,4-d]pyrimidine.
El Fal M, Ramli Y, Essassi el M, Saadi M, El Ammari L. El Fal M, et al. Acta Crystallogr Sect E Struct Rep Online. 2013 Oct 16;69(Pt 11):o1650. doi: 10.1107/S160053681302789X. eCollection 2013 Oct 16. Acta Crystallogr Sect E Struct Rep Online. 2013. PMID: 24454091 Free PMC article.
The pyrazolo-[3,4-d]pyrimidine ring system of the title compound, C12H10N4S, is essentially planar [maximum deviation = 0.025 (1) A for the C atom bearing the S atom] and almost perpendicular to the phenyl ring [dihedral angle = 71.42 (6)]. ...
The pyrazolo-[3,4-d]pyrimidine ring system of the title compound, C12H10N4S, is essentially planar [maxim …
Thio-substituted derivatives of 4-amino-pyrazolo[3,4-d]pyrimidine-6-thiol as antiproliferative agents.
Cacciari B, Romagnoli R, Romani A, Trentini A, Hanau S. Cacciari B, et al. Future Med Chem. 2021 Sep;13(18):1515-1530. doi: 10.4155/fmc-2021-0131. Epub 2021 Jul 12. Future Med Chem. 2021. PMID: 34251285
However, two of them (4b and 4l) were specific against cancer cells, with 4l presenting high selectivity. The presence of substituted pyrazolo[3,4-d]pyrimidine core is as essential for this activity as the presence of substituents at the thiol f …
However, two of them (4b and 4l) were specific against cancer cells, with 4l presenting high selectivity. The presence of substituted pyr …
The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma.
Rango E, Pastorino F, Brignole C, Mancini A, Poggialini F, Di Maria S, Zamperini C, Iovenitti G, Fallacara AL, Sabetta S, Clementi L, Valoti M, Schenone S, Angelucci A, Ponzoni M, Dreassi E, Botta M. Rango E, et al. Biomedicines. 2022 Mar 12;10(3):659. doi: 10.3390/biomedicines10030659. Biomedicines. 2022. PMID: 35327462 Free PMC article.
Si306, a pyrazolo[3,4-d]pyrimidine derivative recently identified as promising anticancer agent, has shown favorable in vitro and in vivo activity profile against neuroblastoma (NB) models by acting as a competitive inhibitor of c-Src tyrosine k …
Si306, a pyrazolo[3,4-d]pyrimidine derivative recently identified as promising anticancer agent, has show …
Development of Pyrazolo[3,4-d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme.
Greco C, Taresco V, Pearce AK, Vasey CE, Smith S, Rahman R, Alexander C, Cavanagh RJ, Musumeci F, Schenone S. Greco C, et al. ACS Med Chem Lett. 2020 Feb 13;11(5):657-663. doi: 10.1021/acsmedchemlett.9b00530. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435367 Free PMC article.
Overall, this study led to the identification of a set of polymer-formulated pyrazolo[3,4-d]pyrimidine kinase inhibitors as promising candidates for GBM preclinical efficacy studies....
Overall, this study led to the identification of a set of polymer-formulated pyrazolo[3,4-d]pyrimidine ki …
870 results