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5-O-Alkylated derivatives of 5-hydroxy-2'-deoxyuridine as potential antiviral agents. Anti-herpes activity of 5-propynyloxy-2'-deoxyuridine.
Torrence PF, Spencer JW, Bobst AM. Torrence PF, et al. J Med Chem. 1978 Feb;21(2):228-31. doi: 10.1021/jm00200a018. J Med Chem. 1978. PMID: 202709
Alkylation of 5-hydroxyuridine or 5-hydroxy-2'-deoxyuridine with various activated alkylating agents in the presence of 1 equiv of NaOH gave a series of new nucleoside analogues which were evaluated for antiviral activity against vaccinia virus, herpes simplex-1 virus, and vesicu …
Alkylation of 5-hydroxyuridine or 5-hydroxy-2'-deoxyuridine with various activated alkylating agents in the presence of 1 equiv of NaOH gave …
5-Ethoxy-2'-deoxyuridine, a novel substrate for thymidine phosphorylase, potentiates the antitumor activity of 5-fluorouracil when used in combination with interferon, an inducer of thymidine phosphorylase expression.
Schwartz EL, Baptiste N, Megati S, Wadler S, Otter BA. Schwartz EL, et al. Cancer Res. 1995 Aug 15;55(16):3543-50. Cancer Res. 1995. PMID: 7627962
A comparable antitumor effect was also found when a related nucleoside analogue, 5-propynyloxy-2'-deoxyuridine, was used with FUra+IFN, and it also showed modulating activity when used with only FUra. ...
A comparable antitumor effect was also found when a related nucleoside analogue, 5-propynyloxy-2'-deoxyuridine, was use …
Potentiation of the antitumor activity of 5-fluorouracil in colon carcinoma cells by the combination of interferon and deoxyribonucleosides results from complementary effects on thymidine phosphorylase.
Schwartz EL, Baptiste N, O'Connor CJ, Wadler S, Otter BA. Schwartz EL, et al. Cancer Res. 1994 Mar 15;54(6):1472-8. Cancer Res. 1994. PMID: 8137250
TP activity was measurable in cell extracts using deoxyinosine as cosubstrate with either thymine or FUra, although activity was only 10% of that measured with deoxyribose-1-phosphate. The pyrimidine analogue 5-propynyloxy-2'-deoxyuridine (PO-dUrd) had 15% of …
TP activity was measurable in cell extracts using deoxyinosine as cosubstrate with either thymine or FUra, although activity was only 10% of …
Synthesis and antiviral activity of 5-[(cyanomethylene)oxy]-2'-deoxyuridine.
Huang GF, Okada M, De Clercq E, Torrence PF. Huang GF, et al. J Med Chem. 1981 Apr;24(4):390-3. doi: 10.1021/jm00136a007. J Med Chem. 1981. PMID: 6267280
To study the influence of substitution of CN for C identical to CH in the anti-herpes virus nucleoside 5-(propynyloxy)-2'-deoxyuridine (1), 5-[(cyanomethylene)oxy]-2'-deoxyuridine (2) was prepared. ...
To study the influence of substitution of CN for C identical to CH in the anti-herpes virus nucleoside 5-(propynyloxy)-2'-d …