Polyalthidin: new prenylated benzopyran inhibitor of the mammalian mitochondrial respiratory chain

M C Zafra-Polo; M C González; J R Tormo; E Estornell; D Cortes

doi:10.1021/np960492m

Polyalthidin: new prenylated benzopyran inhibitor of the mammalian mitochondrial respiratory chain

J Nat Prod. 1996 Oct;59(10):913-6. doi: 10.1021/np960492m.

Authors

M C Zafra-Polo¹, M C González, J R Tormo, E Estornell, D Cortes

Affiliation

¹ Departamento de Farmacología, Farmacognosia y Farmacodinamia, Facultadde Farmacia, Universidad de Valencia, Spain.

PMID: 8904840
DOI: 10.1021/np960492m

Abstract

Polyalthidin (3), a new benzopyran derivative, was isolated from the stem bark of Polyalthia cerasoides. Its structure was established on the basis of chemical and spectral evidence. Polyalthidin has showed potent biological activity as an inhibitor of the mammalian mitochondrial respiratory chain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Benzopyrans / isolation & purification*
Benzopyrans / pharmacology
Cattle
Enzyme Inhibitors / isolation & purification*
Enzyme Inhibitors / pharmacology
Fatty Acids, Unsaturated / isolation & purification*
Fatty Acids, Unsaturated / pharmacology
Humans
Magnetic Resonance Spectroscopy
Mitochondria / drug effects
Mitochondria / metabolism*
Mitochondria, Heart / drug effects
Mitochondria, Heart / enzymology
NADH, NADPH Oxidoreductases / antagonists & inhibitors
Plant Epidermis / chemistry*
Plants, Medicinal / chemistry*
Spectrophotometry, Ultraviolet

Substances

Benzopyrans
Enzyme Inhibitors
Fatty Acids, Unsaturated
polyalthidin
NADH, NADPH Oxidoreductases