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Page 1
Genetic polymorphisms of CYP2A6 affect the in-vivo pharmacokinetics of pilocarpine.
Endo T, Nakajima M, Fukami T, Hara Y, Hasunuma T, Yokoi T, Momose Y. Endo T, et al. Pharmacogenet Genomics. 2008 Sep;18(9):761-72. doi: 10.1097/FPC.0b013e328303c034. Pharmacogenet Genomics. 2008. PMID: 18698229
OBJECTIVE: Pilocarpine is metabolized to pilocarpic acid by plasma esterase and to 3-hydroxypilocarpine by CYP2A6. ...RESULTS: Relatively large interindividual differences were observed in the pharmacokinetic parameters of pilocarpine, pilocarpic acid, …
OBJECTIVE: Pilocarpine is metabolized to pilocarpic acid by plasma esterase and to 3-hydroxypilocarpine by CYP2A6. ...RESULTS: …
HPLC method for the simultaneous determination of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid.
Gomez-Gomar A, Gonzalez-Aubert M, Costa-Segarra J. Gomez-Gomar A, et al. J Pharm Biomed Anal. 1989;7(12):1729-34. doi: 10.1016/0731-7085(89)80187-6. J Pharm Biomed Anal. 1989. PMID: 2490561
A high-performance liquid chromatographic method suitable for the determination of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid is described. The column used is a Spherisorb-CN bonded phase at 25 degrees C. ...
A high-performance liquid chromatographic method suitable for the determination of pilocarpine, isopilocarpine, pilocarpic acid
High-performance liquid chromatographic analysis of pilocarpine hydrochloride, isopilocarpine, pilocarpic acid and isopilocarpic acid in eye-drop preparations.
Kennedy JM, McNamara PE. Kennedy JM, et al. J Chromatogr. 1981 Aug 7;212(3):331-8. doi: 10.1016/s0021-9673(01)84046-2. J Chromatogr. 1981. PMID: 7263802
A high-performance liquid chromatographic method is described which allows the simultaneous estimation of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid. The method offers advantages over existing chromatographic procedures in that pilocarpine a …
A high-performance liquid chromatographic method is described which allows the simultaneous estimation of pilocarpine, isopilocarpine, pi
Determination of pilocarpine, isopilocarpine, pilocarpic acid and isopilocarpic acid in human plasma and urine by high-performance liquid chromatography with tandem mass spectrometric detection.
van de Merbel NC, Tinke AP, Oosterhuis B, Jonkman JH, Bohle JF. van de Merbel NC, et al. J Chromatogr B Biomed Sci Appl. 1998 Apr 24;708(1-2):103-12. doi: 10.1016/s0378-4347(97)00643-9. J Chromatogr B Biomed Sci Appl. 1998. PMID: 9653952
A method is described for the determination of pilocarpine and its degradation products isopilocarpine, pilocarpic acid and isopilocarpic acid in human plasma and urine. The method is based on a simple sample preparation step -- ultrafiltration for plasma and diluti …
A method is described for the determination of pilocarpine and its degradation products isopilocarpine, pilocarpic acid and is …
Pilocarpine prodrugs. II. Synthesis, stability, bioconversion, and physicochemical properties of sequentially labile pilocarpine acid diesters.
Bundgaard H, Falch E, Larsen C, Mosher GL, Mikkelson TJ. Bundgaard H, et al. J Pharm Sci. 1986 Aug;75(8):775-83. doi: 10.1002/jps.2600750811. J Pharm Sci. 1986. PMID: 3772750
Various novel diesters of pilocarpic acid were synthesized and evaluated as prodrug forms for pilocarpine with the aim of improving the ocular delivery characteristics of the drug. ...All diesters were markedly more lipophilic than pilocarpine and the corresponding …
Various novel diesters of pilocarpic acid were synthesized and evaluated as prodrug forms for pilocarpine with the aim of impr …
Synthesis and identification of pilocarpic acid diesters, prodrugs of pilocarpine.
Järvinen T, Auriola S, Peura P, Suhonen P, Urtti A, Vepsäläinen J. Järvinen T, et al. J Pharm Biomed Anal. 1991;9(6):457-64. doi: 10.1016/0731-7085(91)80247-7. J Pharm Biomed Anal. 1991. PMID: 1747398
A series of new pilocarpic acid diesters were synthesized to obtain prodrugs for pilocarpine with varying physico-chemical properties. Thermospray liquid chromatography-mass spectrometry (TSP-LC-MS), liquid chromatography with UV-detection (LC-UV) and NMR-spectrosco …
A series of new pilocarpic acid diesters were synthesized to obtain prodrugs for pilocarpine with varying physico-chemical pro …
Determination of physicochemical properties, stability in aqueous solutions and serum hydrolysis of pilocarpic acid diesters.
Järvinen T, Suhonen P, Naumanen H, Urtti A, Peura P. Järvinen T, et al. J Pharm Biomed Anal. 1991;9(9):737-45. doi: 10.1016/0731-7085(91)80215-u. J Pharm Biomed Anal. 1991. PMID: 1821151
All the compounds are stable in acidic aqueous solution; in serum, however, pilocarpic acid diesters are hydrolysed enzymatically to pilocarpic acid monoester, which undergoes spontaneous cyclization to active pilocarpine and inactive isopilocarpine. . …
All the compounds are stable in acidic aqueous solution; in serum, however, pilocarpic acid diesters are hydrolysed enzymatica …
Separation and analysis of pilocarpine, isopilocarpine, and pilocarpic acid by reverse phase liquid chromatography: collaborative study.
Van Ackeren JL, Venable RM, Wainer IW. Van Ackeren JL, et al. J Assoc Off Anal Chem. 1984 Sep-Oct;67(5):924-6. J Assoc Off Anal Chem. 1984. PMID: 6501156
A method for separating and determining pilocarpine and 2 degradation products was developed and subjected to collaborative study. Pilocarpine, isopilocarpine, and pilocarpic acid were isolated on a reverse phase liquid chromatographic phenyl bonded column and detec …
A method for separating and determining pilocarpine and 2 degradation products was developed and subjected to collaborative study. Pilocarpi …
Decomposition of pilocarpine eye drops assessed by a highly efficient high pressure liquid chromatographic method.
Kuks PF, Weekers LE, Goldhoorn PB. Kuks PF, et al. Pharm Weekbl Sci. 1990 Oct 19;12(5):196-9. doi: 10.1007/BF01980046. Pharm Weekbl Sci. 1990. PMID: 2255589
Pilocarpine in ophthalmic solutions decomposes fairly rapidly to give isopilocarpine, pilocarpic acid and isopilocarpic acid. The quality of an ophthalmic solution can be assessed by assaying these decomposition products. ...However, when stored at room temperature …
Pilocarpine in ophthalmic solutions decomposes fairly rapidly to give isopilocarpine, pilocarpic acid and isopilocarpic acid. …
42 results