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Bioactive phenolic compounds from the flowers of Farfugium japonicum (L.) Kitam. var. giganteum (Siebold et Zucc.) Kitam. (Asteraceae).
Devkota HP, Tsushiro K, Watanabe T. Devkota HP, et al. Nat Prod Res. 2022 Aug;36(15):4036-4039. doi: 10.1080/14786419.2021.1903004. Epub 2021 Mar 24. Nat Prod Res. 2022. PMID: 33759652
The main aim of this study was to isolate and identify the chemical constituents of the 70% EtOH extract of the flowers of F. japonicum var. giganteum and to evaluate their tyrosinase inhibitory and free radical scavenging activities. Five phenolic compounds, namely petasiphen …
The main aim of this study was to isolate and identify the chemical constituents of the 70% EtOH extract of the flowers of F. japonicum var. …
Some anti-chronic inflammatory compounds are DNA polymerase lambda-specific inhibitors.
Mizushina Y, Hirota M, Murakami C, Ishidoh T, Kamisuki S, Shimazaki N, Takemura M, Perpelescu M, Suzuki M, Yoshida H, Sugawara F, Koiwai O, Sakaguchi K. Mizushina Y, et al. Biochem Pharmacol. 2003 Nov 15;66(10):1935-44. doi: 10.1016/s0006-2952(03)00551-3. Biochem Pharmacol. 2003. PMID: 14599551
We previously reported that a phenolic compound, petasiphenol, was a selective inhibitor of DNA polymerase lambda (pol lambda) in vitro. We found here that another phenolic compound, curcumin (diferuloylmethane), which is known as an anti-chronic inflammatory agent and is …
We previously reported that a phenolic compound, petasiphenol, was a selective inhibitor of DNA polymerase lambda (pol lambda) in vit …
Petasiphenol which inhibits DNA polymerase lambda activity is an inhibitor of in vitro angiogenesis.
Matsubara K, Mori M, Mizushina Y. Matsubara K, et al. Oncol Rep. 2004 Feb;11(2):447-51. Oncol Rep. 2004. PMID: 14719082
However, treatment of HUVEC with petasiphenol did not affect 72 kDa matrix metalloprotease activity at these concentrations. Petasiphenol at higher 50 microM also suppressed microvessel outgrowth in ex vivo angiogenesis assay using a rat aortic ring. ...
However, treatment of HUVEC with petasiphenol did not affect 72 kDa matrix metalloprotease activity at these concentrations. Petas …
Structure-activity relationship analysis of curcumin analogues on anti-influenza virus activity.
Ou JL, Mizushina Y, Wang SY, Chuang DY, Nadar M, Hsu WL. Ou JL, et al. FEBS J. 2013 Nov;280(22):5829-40. doi: 10.1111/febs.12503. Epub 2013 Sep 23. FEBS J. 2013. PMID: 24034558 Free article.
To search for a stable Cur analogue with potent anti-IAV activity and to investigate the structure contributing to its anti-IAV activity, a comparative analysis of structural and functional analogues of Cur, such as tetrahydrocurcumin (THC) and petasiphenol (Pet), was perf …
To search for a stable Cur analogue with potent anti-IAV activity and to investigate the structure contributing to its anti-IAV activity, a …
Petasiphenol: a DNA polymerase lambda inhibitor.
Mizushina Y, Kamisuki S, Kasai N, Ishidoh T, Shimazaki N, Takemura M, Asahara H, Linn S, Yoshida S, Koiwai O, Sugawara F, Yoshida H, Sakaguchi K. Mizushina Y, et al. Biochemistry. 2002 Dec 10;41(49):14463-71. doi: 10.1021/bi020476q. Biochemistry. 2002. PMID: 12463744
BIAcore analysis demonstrated that petasiphenol bound selectively to the N-terminal domain of pol lambda but did not bind to the C-terminal region. On the basis of these results, the pol lambda inhibitory mechanism of petasiphenol is discussed....
BIAcore analysis demonstrated that petasiphenol bound selectively to the N-terminal domain of pol lambda but did not bind to the C-te …
Screening of potential phytomolecules against MurG as drug target in nosocomial pathogen Pseudomonas aeruginosa: perceptions from computational campaign.
Lokhande KB, Pawar SV, Madkaiker S, Shrivastava A, Venkateswara SK, Nawani N, Wani M, Ghosh P, Singh A. Lokhande KB, et al. J Biomol Struct Dyn. 2024 Jan-Feb;42(1):495-508. doi: 10.1080/07391102.2023.2194005. Epub 2023 Mar 28. J Biomol Struct Dyn. 2024. PMID: 36974974
Docking results identified Theobromine (-8.881 kcal/mol), demethoxycurcumin (-8.850 kcal/mol), 2-alpha-hydroxycostic acid (-8.791 kcal/mol), aurantiamide (-8.779 kcal/mol) and petasiphenol (-8.685 kcal/mol) as a potential inhibitor of the MurG activity. ...HIGHLIGHTSThe to …
Docking results identified Theobromine (-8.881 kcal/mol), demethoxycurcumin (-8.850 kcal/mol), 2-alpha-hydroxycostic acid (-8.791 kcal/mol), …
Petasiphenone, a phenol isolated from Cimicifuga racemosa, in vitro inhibits proliferation of the human prostate cancer cell line LNCaP.
Jarry H, Stromeier S, Wuttke W, Nahrstedt A. Jarry H, et al. Planta Med. 2007 Feb;73(2):184-7. doi: 10.1055/s-2006-957081. Epub 2007 Feb 13. Planta Med. 2007. PMID: 17295185
Recently, the phenylpropanoid ester 3,4-dihydroxyphenacyl caffeate (petasiphenone, 1) was isolated from CR. This substance is a structural homologue to petasiphenol ([3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate]), a compound produced by Petasites japonicus Sieb. & Zuc …
Recently, the phenylpropanoid ester 3,4-dihydroxyphenacyl caffeate (petasiphenone, 1) was isolated from CR. This substance is a structural h …
[Phenolic components from Petasites tricholobus].
Zhang Y, Guo F, Zeng P, Jia Q, Li Y, Zhu W, Chen K. Zhang Y, et al. Zhongguo Zhong Yao Za Zhi. 2012 Jun;37(12):1782-7. Zhongguo Zhong Yao Za Zhi. 2012. PMID: 22997824 Chinese.
RESULT: Nineteen phenolic compounds were separated from 95% ethanol extracts from P. tricholobus Franch. and identified as sulfonated benzyl glucoside (1), 3-(4beta-D-glucopyranosyloxy-3, 5-dimethoxy) -phenyl-2E-propenol (2), dihydrosyringin (3), tangshenosides II (4), 4-hydroxy- …
RESULT: Nineteen phenolic compounds were separated from 95% ethanol extracts from P. tricholobus Franch. and identified as sulfonated benzyl …
Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda.
Takeuchi T, Ishidoh T, Iijima H, Kuriyama I, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y. Takeuchi T, et al. Genes Cells. 2006 Mar;11(3):223-35. doi: 10.1111/j.1365-2443.2006.00937.x. Genes Cells. 2006. PMID: 16483311 Free article.
We previously reported that phenolic compounds, petasiphenol and curcumin (diferuloylmethane), were a selective inhibitor of DNA polymerase lambda (pol lambda) in vitro. ...
We previously reported that phenolic compounds, petasiphenol and curcumin (diferuloylmethane), were a selective inhibitor of DNA poly …
Isolation and synthesis of a new bio-antimutagen, petasiphenol, from scapes of Petasites japonicum.
Iriye R, Furukawa K, Nishida R, Kim C, Fukami H. Iriye R, et al. Biosci Biotechnol Biochem. 1992 Nov;56(11):1773-5. doi: 10.1271/bbb.56.1773. Biosci Biotechnol Biochem. 1992. PMID: 1369070 Free article.
A new bio-antimutagen, petasiphenol [3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate] (1) was isolated from scapes of Petasites japonicum (AD50 = 95 micrograms/ml against UV-induced mutagenic E. coli WP2 B/r Trp-. Petasiphenol (1) and its isomer (2) were synthesized. T …
A new bio-antimutagen, petasiphenol [3-(3,4-dihydroxyphenyl)-2-oxopropyl caffeate] (1) was isolated from scapes of Petasites japonicu …
12 results