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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 6
1946 18
1947 10
1948 10
1949 8
1950 32
1951 24
1952 30
1953 46
1954 37
1955 45
1956 38
1957 38
1958 36
1959 31
1960 31
1961 24
1962 28
1963 84
1964 112
1965 73
1966 92
1967 123
1968 114
1969 114
1970 96
1971 97
1972 113
1973 106
1974 111
1975 94
1976 106
1977 84
1978 106
1979 95
1980 94
1981 120
1982 117
1983 122
1984 127
1985 131
1986 119
1987 114
1988 125
1989 135
1990 134
1991 160
1992 143
1993 141
1994 119
1995 118
1996 122
1997 115
1998 143
1999 111
2000 131
2001 106
2002 124
2003 114
2004 143
2005 147
2006 136
2007 150
2008 196
2009 175
2010 200
2011 202
2012 212
2013 241
2014 248
2015 234
2016 248
2017 250
2018 234
2019 242
2020 272
2021 262
2022 238
2023 230
2024 48

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8,913 results

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Page 1
Pentylenetetrazole-Induced Kindling Mouse Model.
Shimada T, Yamagata K. Shimada T, et al. J Vis Exp. 2018 Jun 12;(136):56573. doi: 10.3791/56573. J Vis Exp. 2018. PMID: 29985308 Free PMC article.
Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of PTZ into an animal induces an acute, severe seizure at a high dose, whereas sequential injections of a subconvulsive dose have been used for the development of chemical kindling, an e
Pentylenetetrazole (PTZ) is a GABA-A receptor antagonist. An intraperitoneal injection of PTZ into an animal induces an acute, severe
Pentylenetetrazol (PTZ) kindling model of epilepsy.
Dhir A. Dhir A. Curr Protoc Neurosci. 2012;Chapter 9:Unit9.37. doi: 10.1002/0471142301.ns0937s58. Curr Protoc Neurosci. 2012. PMID: 23042503
This unit discusses in detail the methodology to execute pentylenetetrazol (PTZ; a GABA(A) receptor antagonist)-induced chemical kindling in mice. ...
This unit discusses in detail the methodology to execute pentylenetetrazol (PTZ; a GABA(A) receptor antagonist)-induced chemical kind …
Narco-stimulation.
LAVERNE AA. LAVERNE AA. Am J Psychiatry. 1959 Feb;115(8):738-40. doi: 10.1176/ajp.115.8.738. Am J Psychiatry. 1959. PMID: 13617507 No abstract available.
Behavioral analogues of anxiety. Animal models.
Lal H, Emmett-Oglesby MW. Lal H, et al. Neuropharmacology. 1983 Dec;22(12B):1423-41. doi: 10.1016/0028-3908(83)90111-9. Neuropharmacology. 1983. PMID: 6142426 Review.
As an example of this approach, data are reviewed showing that pentylenetetrazol, an anxiogenic drug in humans, produces interoceptive stimuli which can be readily discriminated by rats. Further, these stimuli can be easily quantified through dose-response analysis. All kn …
As an example of this approach, data are reviewed showing that pentylenetetrazol, an anxiogenic drug in humans, produces interoceptiv …
Treating enhanced GABAergic inhibition in Down syndrome: use of GABA α5-selective inverse agonists.
Martínez-Cué C, Delatour B, Potier MC. Martínez-Cué C, et al. Neurosci Biobehav Rev. 2014 Oct;46 Pt 2:218-27. doi: 10.1016/j.neubiorev.2013.12.008. Epub 2014 Jan 9. Neurosci Biobehav Rev. 2014. PMID: 24412222 Free article. Review.
In this review we discuss methods to alleviate neuronal inhibition in a mouse model of Down syndrome, the Ts65Dn mouse, using either an antagonist (pentylenetetrazol) or two different inverse agonists selective for the alpha5-subunit containing receptor. ...
In this review we discuss methods to alleviate neuronal inhibition in a mouse model of Down syndrome, the Ts65Dn mouse, using either an anta …
Optimization of a locomotion-based zebrafish seizure model.
Shaw PAG, Panda SK, Stanca A, Luyten W. Shaw PAG, et al. J Neurosci Methods. 2022 Jun 1;375:109594. doi: 10.1016/j.jneumeth.2022.109594. Epub 2022 Apr 11. J Neurosci Methods. 2022. PMID: 35421798
NEW METHOD: We optimized a locomotor-based seizure assay in zebrafish with pentylenetetrazol (PTZ) as the pharmacological proconvulsant to generate a therapeutic window in which proconvulsant-treated zebrafish larvae could be discriminated from a non-treated control. ...
NEW METHOD: We optimized a locomotor-based seizure assay in zebrafish with pentylenetetrazol (PTZ) as the pharmacological proconvulsa …
Oleanolic acid suppresses pentylenetetrazole-induced seizure in vivo.
Akünal Türel C, Yunusoğlu O. Akünal Türel C, et al. Int J Environ Health Res. 2023 May;33(5):529-540. doi: 10.1080/09603123.2023.2167947. Epub 2023 Feb 22. Int J Environ Health Res. 2023. PMID: 36812380
The aim of this study was to investigate the protective effects of triterpene oleanolic acid on the brain tissue of mice with pentylenetetrazole (PTZ)-induced epileptic seizures. Male Swiss albino mice were randomly separated into five groups as the PTZ, control, and olean …
The aim of this study was to investigate the protective effects of triterpene oleanolic acid on the brain tissue of mice with pentylenete
Antiepileptic Properties of Scyllo-Inositol on Pentylenetetrazol-Induced Seizures.
Wiśniewski K, Antonowski T, Juranek J, Podlasz P, Wojtkiewicz J. Wiśniewski K, et al. Int J Mol Sci. 2023 Apr 20;24(8):7598. doi: 10.3390/ijms24087598. Int J Mol Sci. 2023. PMID: 37108760 Free PMC article.
Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inositol (SCI)-one of the most common commercially available inositols-in zebrafish larvae with pentylenetetrazol-induced seizures. First, …
Inositols have proved effective in many disorders; hence, in the current study, we tested potential antiepileptic properties of scyllo-inosi …
Zebrafish as an Innovative Tool for Epilepsy Modeling: State of the Art and Potential Future Directions.
D'Amora M, Galgani A, Marchese M, Tantussi F, Faraguna U, De Angelis F, Giorgi FS. D'Amora M, et al. Int J Mol Sci. 2023 Apr 22;24(9):7702. doi: 10.3390/ijms24097702. Int J Mol Sci. 2023. PMID: 37175408 Free PMC article. Review.
In ZF, seizures have been induced through a variety of chemoconvulsants, primarily pentylenetetrazol (PTZ), kainic acid (KA), and pilocarpine. Furthermore, ZF can be easily genetically modified to test specific aspects of monogenic forms of human epilepsy, as well as to di …
In ZF, seizures have been induced through a variety of chemoconvulsants, primarily pentylenetetrazol (PTZ), kainic acid (KA), and pil …
[Impaired memory following repeated pentylenetetrazol treatments in kindled mice].
Takechi K, Suemaru K, Kawasaki H, Araki H. Takechi K, et al. Yakugaku Zasshi. 2012;132(2):179-82. doi: 10.1248/yakushi.132.179. Yakugaku Zasshi. 2012. PMID: 22293696 Free article. Review. Japanese.
The aim of the present study was to clarify the effects of kindling-induced epileptic seizures on psychic functioning using behavioral pharmacological tests. Pentylenetetrazol (PTZ)-kindled mice demonstrated no significant differences in locomotor activity and muscle relax …
The aim of the present study was to clarify the effects of kindling-induced epileptic seizures on psychic functioning using behavioral pharm …
8,913 results