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Year Number of Results
1946 8
1947 9
1948 2
1954 1
1961 1
1963 1
1990 1
1995 1
2002 1
2004 1
2005 1
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2012 2
2013 1
2016 1
2024 0

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Page 1
Biologically Active Secondary Metabolites from the Fungi.
Bills GF, Gloer JB. Bills GF, et al. Microbiol Spectr. 2016 Nov;4(6). doi: 10.1128/microbiolspec.FUNK-0009-2016. Microbiol Spectr. 2016. PMID: 27809954 Free article. Review.
Advances in genome sequencing, computational tools, and analytical chemistry are enabling the rapid connection of gene clusters with their metabolic products. At least three fungal drug precursors, penicillin K and V, mycophenolic acid, and pleuromutilin, have been …
Advances in genome sequencing, computational tools, and analytical chemistry are enabling the rapid connection of gene clusters with their m …
Substrate specificity of penicillin acylase from Streptomyces lavendulae.
Torres-Guzmán R, de la Mata I, Torres-Bacete J, Arroyo M, Castillón MP, Acebal C. Torres-Guzmán R, et al. Biochem Biophys Res Commun. 2002 Mar 1;291(3):593-7. doi: 10.1006/bbrc.2002.6485. Biochem Biophys Res Commun. 2002. PMID: 11855830
The enzyme hydrolyses phenoxymethyl penicillin (penicillin V) and other penicillins with aliphatic acyl-chains such as penicillin F, dihydroF, and K. The best substrate was penicillin K (octanoyl penicillin) with a k(cat)/K(m) of 165.3 mM(-1) s(-1). ...
The enzyme hydrolyses phenoxymethyl penicillin (penicillin V) and other penicillins with aliphatic acyl-chains such as penicillin F, dihydro …
THE VARYING BLOOD LEVELS AFFORDED BY PENICILLINS F, G, K, AND X IN RABBITS AND MAN.
Eagle H; Technical Assistance of Arlyne D. Musselman. Eagle H, et al. J Exp Med. 1947 Jan 31;85(2):163-73. doi: 10.1084/jem.85.2.163. J Exp Med. 1947. PMID: 19871605 Free PMC article.
In man, the urinary recovery of G and X averaged 86 and 93 per cent, respectively. In sharp contrast, the urinary recovery of penicillin K averaged 33 per cent in seven rabbits and 28 per cent in six human volunteers. The major portion of the penicillin appeared in …
In man, the urinary recovery of G and X averaged 86 and 93 per cent, respectively. In sharp contrast, the urinary recovery of penicillin …
THE THERAPEUTIC ACTIVITY OF PENICILLINS F, G, K, AND X IN EXPERIMENTAL INFECTIONS WITH PNEUMOCOCCUS TYPE I AND STREPTOCOCCUS PYOGENES.
Eagle H; Technical Assistance of Arlyne D. Musselman. Eagle H, et al. J Exp Med. 1947 Jan 31;85(2):175-86. doi: 10.1084/jem.85.2.175. J Exp Med. 1947. PMID: 19871606 Free PMC article.
The corresponding curative doses in streptococcal infections of white mice were 2.6, 1.3, 14.0, and 0.5 mg. per kg., or relative activities of 50, 100, 9, and 260. 4. Penicillin K was therefore one-tenth as active in vivo as would be implied by its bactericidal acti …
The corresponding curative doses in streptococcal infections of white mice were 2.6, 1.3, 14.0, and 0.5 mg. per kg., or relative activities …
Engineering the substrate specificity of a thermophilic penicillin acylase from thermus thermophilus.
Torres LL, Cantero A, del Valle M, Marina A, López-Gallego F, Guisán JM, Berenguer J, Hidalgo A. Torres LL, et al. Appl Environ Microbiol. 2013 Mar;79(5):1555-62. doi: 10.1128/AEM.03215-12. Epub 2012 Dec 21. Appl Environ Microbiol. 2013. PMID: 23263966 Free PMC article.
Although the natural substrate of this enzyme is not known, this acylase shows a marked preference for penicillin K over penicillin G. Three-dimensional models were created in which the catalytic residues and the substrate binding pocket were identified. ...
Although the natural substrate of this enzyme is not known, this acylase shows a marked preference for penicillin K over penic …
Inactivation of Penicillins G and K by Liver and Kidney.
Tepperman J, Rakieten N, Valley G, Lyon EW. Tepperman J, et al. Science. 1947 Jan 3;105(2714):18-9. doi: 10.1126/science.105.2714.18. Science. 1947. PMID: 17796164
The inactivation of penicillin K is more rapid in the renal-ligated rabbit than in the renal-ligated, eviscerate preparation. Inactivation of penicillin K occurs in the presence of surviving liver and kidney slices. ...
The inactivation of penicillin K is more rapid in the renal-ligated rabbit than in the renal-ligated, eviscerate preparation. …
The Low Therapeutic Activity of Penicillin K Relative to That of Penicillins F, G, and X, and Its Pharmacological Basis.
Eagle H, Musselman A. Eagle H, et al. Science. 1946 May 17;103(2681):618-20. doi: 10.1126/science.103.2681.618. Science. 1946. PMID: 17808405
In the treatment of experimental streptococcal infections in white mice, a pure preparation of K was one-eleventh as active as G, and one-thirtieth as active as X. The above data suggest that penicillin K is inactivated in the body to a greater extent and more rapid …
In the treatment of experimental streptococcal infections in white mice, a pure preparation of K was one-eleventh as active as G, and one-th …
Optimization of culture medium and conditions for penicillin acylase production by Streptomyces lavendulae ATCC 13664.
Torres-Bacete J, Arroyo M, Torres-Guzmán R, De La Mata I, Acebal C, Castillón MP. Torres-Bacete J, et al. Appl Biochem Biotechnol. 2005 Aug;126(2):119-32. doi: 10.1385/abab:126:2:119. Appl Biochem Biotechnol. 2005. PMID: 16118466
This extracellular enzyme recently has been reported to be a penicillin K acylase, presenting also high hydrolytic activity against penicillin V and other natural aliphatic penicillins such as penicillin K, penicillin F, and penicillin dihydroF. ...
This extracellular enzyme recently has been reported to be a penicillin K acylase, presenting also high hydrolytic activity ag …
Functional expression of a penicillin acylase from the extreme thermophile Thermus thermophilus HB27 in Escherichia coli.
Torres LL, Ferreras ER, Cantero A, Hidalgo A, Berenguer J. Torres LL, et al. Microb Cell Fact. 2012 Aug 9;11:105. doi: 10.1186/1475-2859-11-105. Microb Cell Fact. 2012. PMID: 22876915 Free PMC article.
Hydrophobic acyl-chain penicillins were preferred over the rest of the substrates. Penicillin K (octanoyl penicillin) was the best substrate, with the highest specificity constant value (16.12 mM-1.seg-1). ...CONCLUSIONS: This is the first report concerning the hete …
Hydrophobic acyl-chain penicillins were preferred over the rest of the substrates. Penicillin K (octanoyl penicillin) was the …
THE INACTIVATION OF PENICILLINS F, G, K, AND X BY HUMAN AND RABBIT SERUM.
Eagle H; Technical Assistance of Arlyne D. Musselman. Eagle H, et al. J Exp Med. 1947 Jan 31;85(2):141-61. doi: 10.1084/jem.85.2.141. J Exp Med. 1947. PMID: 19871604 Free PMC article.
At high concentrations of K, the rate of inactivation due to the thermolabile factor was negligible, and penicillin K was destroyed no more rapidly than F, G, or X. The rate of inactivation increased as the concentration of penicillin was reduced. At penicillin …
At high concentrations of K, the rate of inactivation due to the thermolabile factor was negligible, and penicillin K was dest …
31 results