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Oxocrebanine: A Novel Dual Topoisomerase inhibitor, Suppressed the Proliferation of Breast Cancer Cells MCF-7 by Inducing DNA Damage and Mitotic Arrest.
Yu L, Han S, Lang L, Song H, Zhang C, Dong L, Jia S, Zhang Y, Xiao D, Liu J, Xu Y, Zhang X. Yu L, et al. Phytomedicine. 2021 Apr;84:153504. doi: 10.1016/j.phymed.2021.153504. Epub 2021 Feb 10. Phytomedicine. 2021. PMID: 33611211
Oxocrebanine caused DNA damage, autophagy, and mitotic arrest in MCF-7 cells. Oxocrebanine also disrupted tubulin polymerization. Accordingly, oxocrebanine held a great potential for development as a novel dual Topo inhibitor for effective breast cancer treat …
Oxocrebanine caused DNA damage, autophagy, and mitotic arrest in MCF-7 cells. Oxocrebanine also disrupted tubulin polymerizati …
Oxocrebanine from Stephania pierrei exerts macrophage anti-inflammatory effects by downregulating the NF-kappaB, MAPK, and PI3K/Akt signalling pathways.
Chulrik W, Jansakun C, Chaichompoo W, Tedasen A, Yotmanee P, Sattayakhom A, Chunglok W, Suksamrarn A, Chunglok W. Chulrik W, et al. Inflammopharmacology. 2022 Aug;30(4):1369-1382. doi: 10.1007/s10787-022-01021-y. Epub 2022 Jul 13. Inflammopharmacology. 2022. PMID: 35831735
Among the five alkaloids isolated from the n-hexane extract, the aporphine alkaloid oxocrebanine exerted considerable anti-inflammatory effects by inhibiting NO secretion. ...Thus, our findings highlight the potential anti-inflammatory effects of oxocrebanine and su …
Among the five alkaloids isolated from the n-hexane extract, the aporphine alkaloid oxocrebanine exerted considerable anti-inflammato …
Protective effects of Stephania pierrei tuber-derived oxocrebanine against LPS-induced acute lung injury in mice.
Chulrik W, Jansakun C, Chaichompoo W, Supaweera N, Tedasen A, Punsawad C, Kimseng R, Rayanil KO, Suksamrarn A, Chunglok W. Chulrik W, et al. Inflammopharmacology. 2023 Aug;31(4):2023-2035. doi: 10.1007/s10787-023-01231-y. Epub 2023 May 2. Inflammopharmacology. 2023. PMID: 37129718
Moreover, in a murine ALI model, oxocrebanine lowers lung injury scores and lung wet/dry weight ratios while reducing inflammatory cell infiltration. ...Hence, oxocrebanine might prove effective as an anti-inflammatory agent for the treatment of lung inflammation... …
Moreover, in a murine ALI model, oxocrebanine lowers lung injury scores and lung wet/dry weight ratios while reducing inflammatory ce …
The first total syntheses of ()-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine and their cytotoxicity against three human cancer cell lines.
Rayanil KO, Prempree C, Nimgirawath S. Rayanil KO, et al. J Asian Nat Prod Res. 2016 Nov;18(11):1042-56. doi: 10.1080/10286020.2016.1177025. Epub 2016 May 5. J Asian Nat Prod Res. 2016. PMID: 27146697
The first total syntheses of ()-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine have been achieved. The crucial step involved the formation of ring C by a microwave-assisted direct biaryl coupling to produce the aporphine skeleton in …
The first total syntheses of ()-norphoebine, dehydrophoebine, oxophoebine, dehydrocrebanine, oxocrebanine and uthongine have been ach …
Research Status and Hotspots of Anticancer Natural Products Based on the Patent Literature and Scientific Articles.
Shen J, Li J, Yu P, Du G. Shen J, et al. Front Pharmacol. 2022 Jun 17;13:903239. doi: 10.3389/fphar.2022.903239. eCollection 2022. Front Pharmacol. 2022. PMID: 35784720 Free PMC article.
At present, antitumor drugs derived from natural products mainly include 1) apoptosis inducers such as curcumin, gallic acid, resveratrol, Theranekron D6, and gaillardin; 2) topoisomerase inhibitors such as camptothecins, scaffold-hopped flavones, podophyllotoxin, oxocrebanine …
At present, antitumor drugs derived from natural products mainly include 1) apoptosis inducers such as curcumin, gallic acid, resveratrol, T …
Cytotoxic and antimicrobial aporphine alkaloids from Fissistigma poilanei (Annonaceae) collected in Vietnam.
Thuy TT, Quan TD, Anh NT, Sung TV. Thuy TT, et al. Nat Prod Res. 2012;26(14):1296-302. doi: 10.1080/14786419.2011.570761. Epub 2011 Nov 11. Nat Prod Res. 2012. PMID: 22077457
Two new aporphine alkaloids: 8-hydroxy-9-methoxy-1,2-methylenedioxyaporphine (1) and 8-hydroxy-3,9-dimethoxy-1,2-methylenedioxyaporphine (2) were isolated from the ethyl acetate extract of Fissistigma poilanei along with five known compounds: oxocrebanine (3), kuafumine (4 …
Two new aporphine alkaloids: 8-hydroxy-9-methoxy-1,2-methylenedioxyaporphine (1) and 8-hydroxy-3,9-dimethoxy-1,2-methylenedioxyaporphine (2) …