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Page 1
Did you mean romiganan OR MBI 226 OR romiganan (19 results)?
From pathogenesis of acne vulgaris to anti-acne agents.
Cong TX, Hao D, Wen X, Li XH, He G, Jiang X. Cong TX, et al. Arch Dermatol Res. 2019 Jul;311(5):337-349. doi: 10.1007/s00403-019-01908-x. Epub 2019 Mar 11. Arch Dermatol Res. 2019. PMID: 30859308 Review.
New approaches including peroxisome proliferator-activated receptor gamma modifier, melanocortin receptor antagonists, epigallocatechin-3-gallate, metformin, olumacostat glasaretil, stearoyl-CoA desaturase inhibitor omiganan pentahydrochloride, K(D)PT, afamelanotide …
New approaches including peroxisome proliferator-activated receptor gamma modifier, melanocortin receptor antagonists, epigallocatechin-3-ga …
MBI-226. Micrologix/Fujisawa.
Isaacson RE. Isaacson RE. Curr Opin Investig Drugs. 2003 Aug;4(8):999-1003. Curr Opin Investig Drugs. 2003. PMID: 14508884 Review.
Micrologix and Fujisawa are developing a gel formulation of MBI-226 for the potential treatment and prevention of various infections caused by both antibiotic-resistant and -sensitive bacteria. In September 2000, a phase III trial of MBI-226 for the po …
Micrologix and Fujisawa are developing a gel formulation of MBI-226 for the potential treatment and prevention of various infe …
Omiganan pentahydrochloride (MBI 226), a topical 12-amino-acid cationic peptide: spectrum of antimicrobial activity and measurements of bactericidal activity.
Sader HS, Fedler KA, Rennie RP, Stevens S, Jones RN. Sader HS, et al. Antimicrob Agents Chemother. 2004 Aug;48(8):3112-8. doi: 10.1128/AAC.48.8.3112-3118.2004. Antimicrob Agents Chemother. 2004. PMID: 15273128 Free PMC article.
The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed against 1,437 recent clinical bacterial isolates and 214 recent clinical yeast isolates. The omiganan was highly active, and minimal bacter …
The activity of omiganan pentahydrochloride (formerly MBI 226; a synthetic cationic peptide) was assessed agains …
Rational design of stapled antimicrobial peptides.
You Y, Liu H, Zhu Y, Zheng H. You Y, et al. Amino Acids. 2023 Apr;55(4):421-442. doi: 10.1007/s00726-023-03245-w. Epub 2023 Feb 12. Amino Acids. 2023. PMID: 36781451 Review.
Antimicrobial peptides under clinical trial: Pexiganan (NCT01594762, 2012-05-07). Omiganan (NCT02576847, 2015-10-13)....
Antimicrobial peptides under clinical trial: Pexiganan (NCT01594762, 2012-05-07). Omiganan (NCT02576847, 2015-10-13)....
Decolonization in Prevention of Health Care-Associated Infections.
Septimus EJ, Schweizer ML. Septimus EJ, et al. Clin Microbiol Rev. 2016 Apr;29(2):201-22. doi: 10.1128/CMR.00049-15. Clin Microbiol Rev. 2016. PMID: 26817630 Free PMC article. Review.
Nasal topical decolonization agents reviewed include mupirocin, bacitracin, retapamulin, povidone-iodine, alcohol-based nasal antiseptic, tea tree oil, photodynamic therapy, omiganan pentahydrochloride, and lysostaphin. Mupirocin is still the gold standard agent for …
Nasal topical decolonization agents reviewed include mupirocin, bacitracin, retapamulin, povidone-iodine, alcohol-based nasal antiseptic, te …
Treatment with the Topical Antimicrobial Peptide Omiganan in Mild-to-Moderate Facial Seborrheic Dermatitis versus Ketoconazole and Placebo: Results of a Randomized Controlled Proof-of-Concept Trial.
Rousel J, Saghari M, Pagan L, Nădăban A, Gambrah T, Theelen B, de Kam ML, Haakman J, van der Wall HEC, Feiss GL, Niemeyer-van der Kolk T, Burggraaf J, Bouwstra JA, Rissmann R, van Doorn MBA. Rousel J, et al. Int J Mol Sci. 2023 Sep 20;24(18):14315. doi: 10.3390/ijms241814315. Int J Mol Sci. 2023. PMID: 37762625 Free PMC article. Clinical Trial.
No significant decreases in Staphylococcus abundances were observed compared to the placebo. Omiganan is well tolerated but not efficacious in the treatment of facial SD. Previously established antimicrobial and antifungal properties of omiganan could not be demonst …
No significant decreases in Staphylococcus abundances were observed compared to the placebo. Omiganan is well tolerated but not effic …
Pharmacodynamic Effects of Topical Omiganan in Patients With Mild to Moderate Atopic Dermatitis in a Randomized, Placebo-Controlled, Phase II Trial.
Niemeyer-van der Kolk T, van der Wall H, Hogendoorn GK, Rijneveld R, Luijten S, van Alewijk DCJG, van den Munckhof EHA, de Kam ML, Feiss GL, Prens EP, Burggraaf J, Rissmann R, van Doorn MBA. Niemeyer-van der Kolk T, et al. Clin Transl Sci. 2020 Sep;13(5):994-1003. doi: 10.1111/cts.12792. Epub 2020 May 1. Clin Transl Sci. 2020. PMID: 32315497 Free PMC article. Clinical Trial.
Omiganan is an indolicidin analog with antimicrobial properties that could be beneficial for patients with atopic dermatitis. ...Patients were randomized to apply topical omiganan 1%, omiganan 2.5%, or vehicle gel to one target lesion once daily for 28 consec …
Omiganan is an indolicidin analog with antimicrobial properties that could be beneficial for patients with atopic dermatitis. ...Pati …
Antimicrobial Peptide Omiganan Enhances Interferon Responses to Endosomal Toll-Like Receptor Ligands in Human Peripheral Blood Mononuclear Cells.
Grievink HW, Jirka SMG, Woutman TD, Schoonakker M, Rissmann R, Malone KE, Feiss G, Moerland M. Grievink HW, et al. Clin Transl Sci. 2020 Sep;13(5):891-895. doi: 10.1111/cts.12789. Epub 2020 Apr 21. Clin Transl Sci. 2020. PMID: 32314872 Free PMC article.
Besides its bactericidal properties, LL-37 is known to have direct immunomodulatory effects, among which enhancement of antiviral responses via endosomal toll-like receptors (TLRs). Omiganan pentahydrochloride is a synthetic cationic peptide in clinical development. …
Besides its bactericidal properties, LL-37 is known to have direct immunomodulatory effects, among which enhancement of antiviral responses …
Omiganan pentahydrochloride in the front line of clinical applications of antimicrobial peptides.
Melo MN, Dugourd D, Castanho MA. Melo MN, et al. Recent Pat Antiinfect Drug Discov. 2006 Jun;1(2):201-7. doi: 10.2174/157489106777452638. Recent Pat Antiinfect Drug Discov. 2006. PMID: 18221145 Review.
Omiganan is the most advanced molecule in the front line of clinical applications of antimicrobial peptides. The mode and site of action of omiganan are not yet settled although its interaction with membranes is known to play a fundamental role. ...
Omiganan is the most advanced molecule in the front line of clinical applications of antimicrobial peptides. The mode and site of act …
47 results